<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21588

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILDNPMPVELNDVDDLFGDGVGLSLPARAQSKQLQQRMDDIRIRGCCQTVAWSRTGSIANITPDGQNLELRFLRRSPDDGSWDLSEPTTCPFVKGLPTIPIVHLVWAGTSSPDLAVIDAVGRVSIVSFSISLNHPFPQRKWDADPTDDVHTVVGAYWLNVSPPNQQASYNVMYGPATKHGNGYTYESSFVHAGGPTHPSPAKSALLTITTHGVIRMFWSQNTNRLEETTMELESISASDELITHASFASEKKHLLLAVATTSKQLKLIRIEIQWGQASQADKATGRPPGNLSPSLIEKHLATTNWLQGGPGDSSLDISMIELSHLEVIPSVVDSTGKNTTPPMVVTARSRTPTESSYQGSQSVVDRWEAIEQKQNLPSAYEQLGGRRNSISSELPAVTQLQKIAPVTANKVVVAFQTTSFGKILVLAFADGTVEYRDRLTFEELYTTQELNKVQNLRQIGWTFADEGPCQQVAFSPTFCSMVQMGEDGKIKWNKLHYPMGDIGNSMQDAQYCGSIAALTVTAAPSMFYQNNYDDLLAIVRPYTTKKRFVQDLVTELIRILKIQIDYSEEIHHDSLVRNGSLQYCLSIMNALGFRGDFHPRSFQGKFSMLFLNVRNVVVLITIASNTPVTVREKLSPLDDPEVIETLVGCARWALDLIAWLMDCLFELMNDNHFQELLTRERFHELAPYLHEKNNVAFHFLMSSSSRGFLSAICRRLAHLEALSGRAIEFYRKQSAVVEGMAGGRAAPQLQQAYQAMQQVTSSALVKVSEVETLLTGLSNEIRQAYQIFLPSLAKSQNNQTQGKQLDMAMKAARVQMELSILLSAAPPAPFLQIIKKFFNTDLPAFRNTVDPGRLFFANYDLLEVEDDEHSLAAKKARGMVYVDVFKRMQIRPSPDKQWRRCSRCTAVMEDVFGSRSGFTFVLGQQRKCSCGGQWTLLPKGHVS
Length946
PositionTail
OrganismGibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.08
Grand average of hydropathy-0.207
Instability index46.03
Isoelectric point6.45
Molecular weight105278.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21588
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     236.92|      99|     230|      26|     146|       1
---------------------------------------------------------------------------
   35-   99 (82.28/73.23)	...............................................................................................................................KQLQQRMDDiriRGCCQTVAWSRT.GSIANITPDGQnLELRFLRRSPDDGSWDLSEPTTCPFVKGL
  107-  146 (28.49/15.89)	LVWAGTSSPDLAVIDAVGRVSIVSfSISLNHPFPQRkWDA.........................................................................................................................................................
  335-  372 (36.96/ 8.68)	VDSTGKNTTPPMVVTARSRTPTES.SYQGSQSVVDR.WEA.........................................................................................................................................................
  460-  521 (89.20/42.95)	........................................ieqkqnlpsayeqlggrrnsisselpavtqlqkiapvtankvvvafqttsfgkilvlafadgtveyrdrltfeelyttqelnkvqnlRQIGWTFAD...EGPCQQVAFSPTfCSMVQMGEDGK.IKWNKLHYPMGDIGNSMQDAQYCGSIAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.51|      17|      30|     740|     757|       5
---------------------------------------------------------------------------
  740-  757 (26.62/21.47)	VEGMAGGrAAPQLQQAYQ
  773-  789 (28.89/17.98)	VETLLTG.LSNEIRQAYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      19|     288|     258|     276|       8
---------------------------------------------------------------------------
  258-  276 (32.10/23.42)	LLAVA...TTSKQL......KLIRI.EIQ
  538-  566 (16.90/ 9.04)	LLAIVrpyTTKKRFvqdlvtELIRIlKIQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21588 with Med16 domain of Kingdom Fungi
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