<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21586

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPASEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAMNGNSTVPNSDVEDGSGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFSGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPTPLTRQEQIQWISDLDTQLSLRLNLEDFDKIPYHFRNYEIDSGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFEPAASSIPDGLKNYLEGQVNDILSKDGLLGCYQFLHELVLTHKLNELKRQASQLSRGSWTGTLKVEPLNRALAIQYWTSRTQLGSPKSWILVAVNSGRKPNGQPDPKSSSHLVAKWYRDNKEVKDTNISFDADNLSAETLLKTVIGRHVEFLLGSIHSRLQAFPRFQNRDAAMILNISHDDPATSFLSMQVGYKDSASLLVEPTTGVFAVKPHSKFTIQHEHSLNNGKNPADDGAACLENVRCGVMEDELIRRGSTTGWTTKKSPLSKDELRSLTNTREWTKTIWLQRTGWDPNWFVMVMLSPSGDAWWLVDVSRNANGQSNRLSSKLPLNKGYPHLEDEFWNNLTLFATGMIAQAVDQHELYRHNIRFLLKNTRNWSLPQQVRLPTLEISLSDIFPSMVPNTAEKNNAKAANESSTGPETSRLGPVAPTASTSGISTRQPWADNIVSIRFKGVEPVDKEASGAGGPISDVAFMCVSDAIIKVSKPAKFAMLKGHMVGRDVSWKARTGEFCLRMRSNIGRSILENLKARVKAVDRFVSFFESLDKARGFIKAESVSLKEVTFSYGPPASQAVENAEASRLWRVALDLSNNNIDIQVQETNPHLPVTDLMQKLVNGANGIGALMDWLPVSLPTMEAFKKIREAWSDIEAHRHGRFKFVMNSTDEMSFEYLLAGTGPGNQQVQRSITFLGQIKQRRGEPWWHIERKIPSSGLPSSNDEFSAALKPVWDGKGDDWRGLVTGAAGRPENGIIGLLLAIDEAIRPLAGSTFQNNPEVVILE
Length1019
PositionTail
OrganismGibberella intermedia (Bulb rot disease fungus) (Fusarium proliferatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.08
Grand average of hydropathy-0.343
Instability index34.21
Isoelectric point6.79
Molecular weight113738.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21586
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     389.86|     124|     143|     657|     796|       1
---------------------------------------------------------------------------
  662-  773 (151.60/129.94)	...........................PE.TSRLGPVAPTASTSGISTRQ.PW......ADNIVSIRFKGVEP....VDKEASGAGGPISDVAFMcvsDaIIKVSKPAKFAMLKGHMVGRDVSwKARTGEFCLRMRSNIGRSiLENLKARV
  774-  916 (185.56/134.47)	KAVDRFVSFFESLDKARGfikaesvslKEvTFSYGPPASQAVENAEASRL..WrvaldlSNNNIDIQVQETNPhlpvTDLMQKLVNGANGIGALM...D.WLPVSLPTMEAFKKIREAWSDIE.AHRHGRFKFVMNSTDEMS.FEYLLAGT
  921-  969 (52.70/28.10)	QQVQRSITFLGQIKQRRG................................ePW......WHIERKIPSSGLPS....SNDEFSAALKPVWD............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.84|      17|      23|     107|     126|       2
---------------------------------------------------------------------------
  107-  126 (26.23/22.24)	DLRF..........HLQgqeVLFSGALDVM
  132-  158 (23.61/11.80)	DLTFarmpspdlktALQ...VLSTGEAAWM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     450.68|     110|     216|     302|     412|       4
---------------------------------------------------------------------------
  168-  280 (123.15/57.97)	.........PLT....RQEQ.IQ.WIS..DLDTQ.................LSLRLNLEDFDKIPyhfrNYEIDSGRVTFKVAGefevdltiadedfekqfWFID.FR......FAFEPAASSIPDGLKNYLEGQ.VNDIL.SKDGLLGCY.QFLHE
  302-  412 (185.99/93.92)	WTG.TLKVEPLN....RALA.IQYWTSRTQLGSP.................KSWILVAVNSGRKP....NGQPDPKSSSHLVAK.................WYRD.NKEVKDtNISFDADNLSAETLLKTVIGRH.VEFLLGSIHSRLQAFPRFQNR
  499-  627 (141.54/67.56)	TTGwTTKKSPLSkdelRSLTnTREWTKTIWL.QRtgwdpnwfvmvmlspsgDAWWLVDV..SRNA....NGQSNRLSSKLPLNK.................GYPHlEDEFWN.NLTLFATGMIAQAVDQHELYRHnIRFLLK..NTRNWSLPQ.QVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21586 with Med14 domain of Kingdom Fungi
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