<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21580

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMGDDYVAVNRMPWMHRENPVAPCRPTEPWRAPTFMQGPTHRAGQTAEPRLQQTSFRAARIAAAMDSLNNVALRPWPEPRKEELTQEDLLFKIEQLASERGHLRNVTEQSLQEDIDAGKDVPDKDNGAKKEQNEKDAPSRQEQMEKVFKAGQEMYSHLEWAKFAATNALDLVSLVLSQGPNKRSLNFFSPTFREQGLDQGIPLGSFGMSREKHEHRIRKPEEQQRLQDVEARQEVVAQGARMGALDSSVDDILKAAKHLEKEIRRETKYWHEIVSVSDKGWPIQRLRQNVRHAPFAVRYGLPEASDHFKARGLAPLRMDKDGSIILDPALALKPKTLRVRLSVDGEITGTSQIPVDGHLASQSLEKSIQTARDSLLEEELYYEMSLETRQLLAYGVEFRDSVIYVDAPQMGNTSQKRKLLIDCVPRDDPIASSQSREHDWLARNIAEGLRLLLAHEHSMRLYRRSQLPPPLTGKKQEKLPPPLLRTLLAIIHHIEGVDSLYAYLASIAQTLHSAGLHVALDTTRETSWAKFVESLGASSKTGLSATDQLFEIFMKPFDGKATLTLPTSTATQPETLSIVTRTIIGQPTFGTEHRLTLPSTLSSDLGLFHQQKFTTVEELKSYLDWILSLHVAHRLLKNDYLSYAQVRSQEARLSIRSKDSKKGTSLSKDIRIDFNDGELKVSCLAVDAPQECEDAEHSHSWSGKDDDNSLREVVKNWPQIQQQIVPSSCLSWYLTCITVSKSGRKFSNYPSGLDPNNTNTGTNNKHAVAELLPNGTEIPYPSFAINNPPNGAINYTVTPPVGANYADYLLGVQSVVLDAADRLWILDTGRSLTPEGVLVPAVTGGPKLIGVDIETDTVIQTITFPDTVAYPTSYLNDVRFDMRASLTESGKGVAYITDSSSAGRNGIVIVDLGTGESWRHLDGVAEVGAERGFVPYVWGQPLYYIPGPGEPLVTVPLGSDGIALSADGADLYFGSVGGRMLYSVPTALLRERDMSSELRAQAGVVRRGDRGLSDGFETDSNGFVYAGNMEQNQIGFYNPANASMEGWVRDPRISWVDTMSVGSDGYLYFTDNQLAFSSSFYPGVDRRERPFVLFRAALPNNGSRVFLQ
Length1107
PositionHead
OrganismStemphylium lycopersici
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Stemphylium.
Aromaticity0.08
Grand average of hydropathy-0.436
Instability index42.34
Isoelectric point5.79
Molecular weight123069.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21580
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.38|      18|      28|     938|     955|       1
---------------------------------------------------------------------------
  938-  955 (36.23/20.30)	GQPLYYIPGPGEPLVTVP
  967-  984 (34.15/18.71)	GADLYFGSVGGRMLYSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.69|      25|      29|     748|     776|       2
---------------------------------------------------------------------------
  748-  776 (33.98/28.98)	YPSgLDPNNTNTGTNNkHAVAEllPNGTE
  779-  803 (48.71/25.26)	YPS.FAINNPPNGAIN.YTVTP..PVGAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     391.46|     102|     104|     156|     259|       3
---------------------------------------------------------------------------
   49-  144 (124.49/59.65)	RLQQTSFraariaAAMDSLNNVALRPWPE.PRKE.ELTQEDLLFK...IEQ...LAS................ERgHLRNVTEQSLQEDIDAGKD.VPDKDNGAKKEQNEKDAPSRQEQME
  156-  259 (162.74/84.22)	HLEWAKF......AATNALDLVSLVLSQG.PNKR.SLNFFSPTFReqGLDQGIPLGS..F...GMS..R.EKHEH.RIRKPEEQQRLQDVEARQEVVAQGARMGALDSSVDDILKAAKHLE
  265-  364 (104.24/48.95)	..............ETKYWHEIVSVSDKGwPIQRlRQNVRHAPF...AVRYGLPEASdhFkarGLAplRmDKDGS.IILDPALALKPKTLRVRLSV..DGEITGTSQIPVDGHL.ASQSLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.46|      17|      17|     991|    1007|       4
---------------------------------------------------------------------------
  991- 1007 (28.61/18.86)	RDMSSELRAQA.GVVRRG
 1009- 1026 (25.85/16.28)	RGLSDGFETDSnGFVYAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.07|      10|      29|     556|     565|       5
---------------------------------------------------------------------------
  556-  565 (18.52/10.19)	FDGKATLTLP
  588-  597 (19.55/11.15)	FGTEHRLTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.17|      37|     157|     897|     935|       6
---------------------------------------------------------------------------
  897-  935 (61.29/49.99)	DSSSAGRNG.IVIVDLGTGESWRHLDGVAEvgAERGFVPY
 1056- 1093 (62.89/44.20)	DTMSVGSDGyLYFTDNQLAFSSSFYPGVDR..RERPFVLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.87|      40|     279|     368|     408|       7
---------------------------------------------------------------------------
  368-  408 (64.68/54.85)	QTARDSLLEEELYYEMSL..ETRQLLAYGvEFRDSVIYVDAPQ
  648-  689 (63.19/48.22)	QEARLSIRSKDSKKGTSLskDIRIDFNDG.ELKVSCLAVDAPQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21580 with Med17 domain of Kingdom Fungi
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