<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21578

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSGLPPRSQVQRRPSKPLHTLVQPDCIDPNLEDERPPPTHNAVNDQARPPPRGRPPLFYTTIPTYAPDPALHSFPYQPAANLPVPPRPGSVHLRDASQQRRILPGGTGVKDAPKPGGPELVVPPVHFPGGKAADVFPWTGNNAEDNLSEALVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPTTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIANIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCASERLFIWLLVVSISHYWADVTCCRRRGKRLAESLLNQLDRIYRLEDLEPYRAVLQYLENTIVRLLATRPACLLLPTAWVQYSPLLQKLAERRNHAHVTQAVRRLEQRNCRLLKTPQNASSASQTLAGRIYRILDSVDYNKPVRIEDLSFDCMEIIADAPRLIGILLRWACTCYREGIHRIYLATRLLRRWNHLGADVYDGIISYLREMSWVATGEPAILFKIVAELVRSKTFATGRYLQWLIATGSVEHSTDLSLPTSWPLRLVTEIPLTGLPDQIRTLRSTLLRGTVHSPELEQRALGYAQHMIAQTLPTLFGLYSATTRLNEAELDKLSSTVKFELGIWLRRQVAQYAEVNQHVPTKDSSEETAAVSLLTPLDFHVVRSYLERFGDLAILADIVGIATSSLDSSVLASGADTINYHAKAFRAIGAFDPLFARIAARYAALRTIRFPDRELLLSLASLARTAQTDGQLPQLLNYDLSQLNQRNSLAACSPASDNMGEVMQTGSSSDDEIERILSSGTSMDQQMMGRVLRKIVSNLEEHSAKGSAQLNNHHGWFHRLRCFDEPTFESVVNEWLILSLMAQRTETLRVALPTLAGSGCIALVSFLDTLRACVAKFKTSPSEGGFLSALKGMHIILPSDALAQSCSPQDAYRYRLEQRKLCLETEGRFVQCISELIGLGSMMSSQKIQMQLANLLRSRPVLSVLNSRIVTDPACLSKLSKDASSDCFKQSLDVLLDPNNHMRLAEKTPEQQVVAVFALASELSLPICQAAIERIFSSRAAGPEGSSEALSATLLNAIRTAVEEDQPSGLELLASLDATLTDQIRQHAEREVIGASAFLTESATTKSEHSETVSPKTVQKFLTVIDLTSGKSAETTDQSVLLQALIERLKGMTQALDDNRLSVLDIYAWLNALLRLAVSHASTMLSNATHPHQTAMMSAMAALLTHPSLELYPTITEHVFDATVFLSDYISDDVRFHVTRLDGARLANDSRCVFILGVTAPVDGWLVLARPVNAPPVQASSQPATPTPLQGQPSPYQSPQTSAAGSATPQQRYLNQQQRQQQMQAAQQAQQMRNMQQYPQHPQNKMLPAQLQRTPSGQAPPTPLSQMQQMQQMQQRAMQPSPVYSQRPTPAASQGQASNQGQMGAQAPSKLQIKQEREIRHYPFVQPRWEILAESSGNPNGNETAINLSLFGARRV
Length1562
PositionKinase
OrganismStemphylium lycopersici
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Stemphylium.
Aromaticity0.06
Grand average of hydropathy-0.281
Instability index51.61
Isoelectric point8.87
Molecular weight173083.62
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP21578
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.08|      18|      20|    1416|    1433|       1
---------------------------------------------------------------------------
 1395- 1415 (20.40/ 7.22)	LQGQPSPYQSPQTSaagSATP
 1416- 1433 (33.68/17.21)	QQRYLNQQQRQQQM...QAAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.67|      18|      20|      51|      68|       2
---------------------------------------------------------------------------
   28-   45 (20.88/ 7.61)	...RRPskPLHTLVQPDCIDP
   48-   66 (30.11/14.40)	EDeRPP..PTHNAVNDQARPP
   67-   84 (27.68/12.61)	PRgRPP..LFYTTIPTYA.PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.00|      12|      15|     259|     272|       4
---------------------------------------------------------------------------
  259-  272 (16.56/14.87)	IPhgLTGKVLLEQC
  277-  288 (23.44/12.36)	IP..LPRALWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.51|      21|      25|    1467|    1487|       5
---------------------------------------------------------------------------
 1434- 1449 (26.33/12.56)	......QAQQMRNMQQYPQHPQ
 1467- 1487 (43.22/25.82)	PTP.LSQMQQMQQMQQRAMQPS
 1494- 1515 (34.95/19.33)	PTPaASQGQASNQGQMGAQAPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.56|      18|      25|     102|     122|       6
---------------------------------------------------------------------------
  102-  122 (29.43/20.80)	PRPGSVHLRDASQQrriLPGG
  129-  146 (37.13/18.77)	PKPGGPELVVPPVH...FPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.15|      20|      20|    1228|    1247|       7
---------------------------------------------------------------------------
 1228- 1247 (30.96/25.47)	LTVIDLTSGKSAETTDQ..SVL
 1249- 1270 (27.19/21.23)	QALIERLKGMTQALDDNrlSVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.89|      10|      15|    1288|    1297|       8
---------------------------------------------------------------------------
 1288- 1297 (19.18/11.86)	STMLSNATHP
 1304- 1313 (17.70/10.33)	SAMAALLTHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.11|      18|      20|     790|     807|       9
---------------------------------------------------------------------------
  790-  807 (31.92/19.69)	AFRAIGAFD.PLFARIA..AR
  810-  830 (21.18/10.43)	ALRTIRFPDrELLLSLAslAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.65|      17|      25|     533|     551|      10
---------------------------------------------------------------------------
  533-  551 (27.01/33.70)	ILLRW...ACTCYrEGIHRiYL
  555-  574 (27.63/20.87)	LLRRWnhlGADVY.DGIIS.YL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.23|      10|      16|     229|     238|      11
---------------------------------------------------------------------------
  229-  238 (17.56/ 8.11)	PRLTLRDSTR
  248-  257 (17.67/ 8.21)	PTTGLRRLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.77|      11|      25|     356|     372|      12
---------------------------------------------------------------------------
  356-  372 (13.83/23.07)	HFldWIvnglD.TCASER
  384-  395 (21.94/11.68)	HY..WA....DvTCCRRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.31|      19|      25|     416|     437|      13
---------------------------------------------------------------------------
  416-  437 (22.94/26.98)	LEPyRAVLQYleNTIVRLLATR
  442-  460 (34.38/23.69)	LLP.TAWVQY..SPLLQKLAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.31|      17|      25|     157|     173|      14
---------------------------------------------------------------------------
  157-  173 (27.61/17.99)	NNAEDNLSEAL.VKAGVS
  183-  200 (24.69/15.28)	NTARPSLINNLkNKSGLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.40|      74|     427|     604|     679|      16
---------------------------------------------------------------------------
  604-  679 (126.63/74.75)	GRYLQ...WLIATGSVEHSTDLSLPTSWPLRlvTEIPLTGLPDQIRTLRSTL..LRGTVHSPELEQR...ALGYAQHM.IAQTLP
 1033- 1115 (106.78/57.85)	GRFVQcisELIGLGSMMSSQKIQMQLANLLR..SRPVLSVLNSRIVTDPACLskLSKDASSDCFKQSldvLLDPNNHMrLAEKTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.51|      16|      19|    1331|    1349|      18
---------------------------------------------------------------------------
 1331- 1349 (20.83/22.93)	FLSDyiSDDVrF..HVT.RLDG
 1352- 1370 (21.68/11.00)	LAND..SRCV.FilGVTaPVDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.58|      13|      25|     952|     964|      19
---------------------------------------------------------------------------
  952-  964 (20.65/13.86)	ETLRVALPTLAGS
  974-  986 (21.93/15.26)	DTLRACVAKFKTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.15|      13|      24|     469|     481|      20
---------------------------------------------------------------------------
  469-  481 (22.53/14.76)	AVRRLEQRNCRLL
  490-  502 (21.61/13.81)	ASQTLAGRIYRIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21578 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DPALHSFPYQPAANLPVPPRPGSVHLRDASQQRRILPGGTGVKDAPKPGGPELVVPPVH
2) MTSRPGPGIHESLQNRGSGLPPRSQVQRRPSKPLHTLVQPDCIDPNLEDERPPPTHNAVNDQARPPPRGRPPLFYTTIPT
3) NAPPVQASSQPATPTPLQGQPSPYQSPQTSAAGSATPQQRYLNQQQRQQQMQAAQQAQQMRNMQQYPQHPQNKMLPAQLQRTPSGQAPPTPLSQMQQMQQMQQRAMQPSPVYSQRPTPAASQGQASNQGQMGAQAPSKLQIKQEREIR
4) NLSEALVKAGVSNKPQIMNESNTARPSLINNL
84
1
1379
162
142
80
1526
193










Molecular Recognition Features






MoRF SequenceStartStop




1) LFYTTIPTY
73
81