<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21575

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAIAYQAVSIASITTTPIAAKTRDWAASDDVRAAEAELRCALHLVAQDASRPWLWLFKPTTAEKIGQHTVPLPEIHGYRLHREQAGSIKAIDLVRPPMRAATPHTTATSNNPPSTTGPPRGLQAANPRSAQATAQPQPSSDSPQPPDCFTLYELFTSSVIALISFHVVRDCDVVALNYRTFVSKAAKQTDRAHAELESQPEAHRLTSINLHWTSSGTLLLSTFTDQKNLIRCLTSVSTQDEERQLTGKCVRVAPNGLLATITSFDDPLDSLTHEIAIRTRKRTRVTTLEQNVEKWKSSVKRWLAWKGYSLADLEKRTSWVRIRATLATPTASSPASIGPERDVLWPRALCFFHVSEEPDTTAMGINNTSATRDSNILRWLETPESLGFKDPIDAAQEWFLGKPNRDKILEARRKAKKAEEDAVRRKEEHHSLHPSSPLNARNSAYGDLQAVSGVYPTPPDGIAPGTGVSHSDTPSVSGTAPNVILAPGGSNPAINLSAPPESTKTDEQMTLTSPVLPSATENFNTSSANDDLFEDMDETGYGGDGINDTDFDFFDGPDDDVDMLDAPALPDNNAPSADPTHIRESEAAAEPQTQEDMSDPFAALENALATASEPAMEDSNVKGKEPEERKAPDVKGPVIPEDKKSLPADRKVLFSKEPTPPLSPGAIFKALEPSPPKKTGSRVRSESVNDSQHDTHFDPVTFNRKMSLSDAKYQGGRFSAHRPKDLVVKDEPSPTSCLGTAAAQPKSLREFPLLSKLRFAAGIASANRIPEIASLARAVSEDSDSSSETSDESDQNSGDEQAEATPAAIMGGLTMPTKRKLQSEGNATPMSVTSFAESIGGDWLELCGLQLDEANLSSFEPSLWDWSLINLSSPAERPAAGARYSLPALLPSPAQMPDTPTSQPDLANEVAEEKPFSGKDSISITQIVTDQVVSTTLDMLGEDSLTRRDLDNDVIVETPWHSVIKQIFPAAADCDLQTLAGVNEVFQDYAALAKAQQRPPARKNDGPAVTGSHMYQIQAPFLRVRRAEAHWDLLPPAVAFWEPLGLSPISHPKNIVTFCVYPHSDAIRPCLENFLLNMQLAYDGCKLGSHSRVETVVEFEGGLVPVRATSAITPRETFKLLRETCVQLGKLLAIQHSKIREQQDSKIDAFVVYMIDPFDGSSALWELCSAFWALFQAYTQGHPGRPDQSQKPDVVLQIIPIKYIASFDAPVILDPSTYFSLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEETLPRNIPFKLVSEPAHDLLRENTYMHLGYAISLDEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAIDSDPPYRFIPIVPAPSTTTGAGATTPGSTPQASVSPSDPGPGLTPAATPSADTAIDPAADPEARLIDITDDTWGVILAHRLHNSHSTTQFSPALISGLLVKRGETQQTCNSVPHPIPDPERGPIVVAVNFLWIGAVGSTRAAANSPFAPPPTSSSTPSSSASSTSSSSSSSDLPSPGGSNLPNPYASAPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGSRNGTVPWHVVAAKRGVEGLGKIRGNGMAM
Length1634
PositionKinase
OrganismStemphylium lycopersici
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Stemphylium.
Aromaticity0.06
Grand average of hydropathy-0.373
Instability index48.76
Isoelectric point5.26
Molecular weight176779.25
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21575
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.07|      19|      20|     474|     493|       2
---------------------------------------------------------------------------
  474-  492 (38.25/15.04)	TPPDGIAPGTGVSHSDTPS
  648-  662 (21.33/ 6.18)	.APDV..KGP.VIPEDKKS
  676-  691 (28.50/ 8.05)	TPP..LSPG.AIFKALEPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     153.56|      20|      20|    1533|    1552|       3
---------------------------------------------------------------------------
  135-  154 (33.15/13.36)	PPRG..LQAANPRSAQATAQPQ
 1398- 1416 (28.39/10.20)	PGPG..LTPAATPSADTAIDP.
 1508- 1525 (22.82/ 6.50)	PPPT..SSSTPSSSASSTSS..
 1533- 1552 (37.82/16.46)	PSPG..GSNLPNPYASAPGTPQ
 1554- 1574 (31.38/12.18)	PGPGqeGQRSTTSLMWTP.TPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     307.42|      95|     555|     306|     410|       4
---------------------------------------------------------------------------
   94-  193 (40.22/12.40)	..................GYRLhreqAGSIKAIDLVRPPMRAATPhtTA........TSnnpPS...TTGpprglqaanprsaqataqpqpssdspqpPDC...........FTLYELftssviALISFHVVRDCDVVAL...............................
  306-  410 (155.22/101.65)	EQNVEKWKSSVkrWlAWKGYSL....ADLEKRTSWVRIRATLATP..TA........SS...PA...SIG............................PER...........DVLWPR......ALCFFHVSEEPDTTAMginNTSATRDSnilrWLETPESLGF.KDPID
  498-  564 (59.81/25.15)	.....................................PNVILA.P..GG........SN...PAinlSAP............................PEStktdeqmtltsPVL.PS......ATENF..............NTSSANDD....LFEDMDETGYgGDGIN
  870-  921 (52.17/19.89)	EANLSSFEPSL..W.DWSL.............INLSSPAERPAA...GAryslpallPS...PA...QM.............................PDT...........PTSQP......................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.86|      21|     128|    1046|    1069|       5
---------------------------------------------------------------------------
 1046- 1069 (37.08/30.43)	AHWDLlppAVAFWEPLGLSPISHP
 1180- 1200 (42.78/25.45)	ALWEL...CSAFWALFQAYTQGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.13|      70|     128|     792|     867|       6
---------------------------------------------------------------------------
  792-  867 (103.72/73.09)	LARAVSEDSDSSSETSDESDQNSGDeQAEATPAAIMGGLTMpTKRKLQSEGNA.TP.MSVTSFAESIGGDwlelCGLQ
  923-  994 (108.41/59.35)	LANEVAEEKPFSGKDSISITQIVTD.QVVSTTLDMLGEDSL.TRRDLDNDVIVeTPwHSVIKQIFPAAAD....CDLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.53|      31|     141|    1448|    1481|       7
---------------------------------------------------------------------------
 1448- 1481 (50.17/39.74)	QFSpALisGLLVK.RGETQQTCNSVPHPIPDPERG
 1589- 1620 (53.35/31.02)	QFR.AL..GLLAKlRGMRGSRNGTVPWHVVAAKRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.78|      22|      57|    1216|    1238|      10
---------------------------------------------------------------------------
 1216- 1238 (35.97/27.06)	IPIKYIaSFDAPVILDPSTYFSL
 1276- 1297 (40.81/26.17)	IPFKLV.SEPAHDLLRENTYMHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21575 with Med13 domain of Kingdom Fungi
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