<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21572

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHTAADAATPSRDGTNMKRNHDGSLINGNPKDASINGASASNTSLAQYSDLPPEIAHIGPEQYNALSTLLLRISQESYNDMAAMLQKMAELPIAPMANGALSNGLGAANMQGNAESNKRKKLLLLQFAHEQRSKFIKLLVLAEWGKKAALDISKLIDLFSWAGAQARHMDAADDQLDRIKVLSNIARENNPDIATALQVLSTGKASWMPSLGYIPPEPISSDQALNLLRYMNTSLSIRLNVHENLPRHLRNWRIHSGRVTFVIDNEFEFDVMSFVEDASEQWFLIDLRLLFNPAPVVTVGSRFFIQLKQQADMVLKDKRLTGLFDFLNNFTLTHKISILRSQAAALARAGWAGSLKVEPVHRLLVVQYWTNRPGKKNWIEIGISNNRPKNGKVSWRGPPIPSLTTRWFRQGKEVKDAPLKFDWSDLSMEKIIKLVIARHTSDILRSTKESLRTGILADSNLSEAEPADCTLNATLGTKSASITLSLEPVTGNYIMRPASALAARAEHAFNLGREPAQMAHVMTQVLATTLAGLIQRNAQQLGWQVVARQALKPQVLKAAVKLDVIQSALYWPSRWSSNWAFAAIIDSSGESWWILEIGSDGNSIEHAEQIRMDRPDGSSLPINRKTLASLERVAIQLLSFRITARQLAKEKKMYSLEEELGQTGTPPEARRIARRWVMRVQTPDLLATKFGQDPWLESDIKITCEGLRAGGQNVWHMATGRMVKSVAADMHKLMAASPQKAFKFSDDGNFRILLSTPFGQDILGELRARLRDVNRLRTFATTLQKRQMRLVSSSLQRVQFQYGPSPYTAAVNFSSEKEVSIELSHNNPHHRIHNLLTEIANDRLPSFLTIDPSDANGLDRFCTTLVITRPMFKIIREIEQRSPGNCRNPAIHVHSILKYRLTYENPVCTFDVRLQPKDDKVYWFVEDNLRPKDPNVLPTPERGQGHRRLDNLQEKLKELFSGKATGWFGTRNGMVAELDAIPDALRKLDDCVMSCKMEGGYVAPPPLERPAQQAQNPNQALPQANGAQQGNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQARMHQQQQQARQQQARKQQPNQQHNPRAQQQNGRPQQIPNRQQQMQQQGRGGRPGQNQNNVIEID
Length1131
PositionTail
OrganismStemphylium lycopersici
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Stemphylium.
Aromaticity0.06
Grand average of hydropathy-0.560
Instability index50.01
Isoelectric point9.63
Molecular weight127420.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21572
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     149.30|      16|      16|    1033|    1048|       1
---------------------------------------------------------------------------
 1021- 1036 (25.39/ 7.58)	ALPQANGAQQGNQQQQ
 1037- 1052 (35.28/13.02)	QQQQQQQQQQQQQQQQ
 1053- 1068 (32.50/11.49)	QQQQQQQQQQQQQQAR
 1071- 1086 (28.91/ 9.52)	QQQQQARQQQARKQQP
 1087- 1102 (27.21/ 8.58)	NQQHNPRAQQQNGRPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      54.32|      12|      15|     138|     149|       2
---------------------------------------------------------------------------
  122-  132 (17.02/ 8.30)	KLLLL.QF.AHEQ
  138-  149 (20.45/11.52)	KLLVLAEW.GKKA
  155-  167 (16.85/ 8.14)	KLIDLFSWaGAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.77|      17|      17|     392|     408|       4
---------------------------------------------------------------------------
  375-  391 (28.49/13.80)	GKKNWIEIGISNNRPKN
  392-  408 (32.88/16.95)	GKVSWRGPPIPSLTTRW
  412-  424 (22.40/ 9.44)	GKEVKDAP....LKFDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.80|      11|      15|     843|     853|       5
---------------------------------------------------------------------------
  843-  853 (20.88/15.29)	DRLPSFLTID.P
  860-  871 (16.92/10.89)	DRFCTTLVITrP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.45|      15|      17|     284|     298|       7
---------------------------------------------------------------------------
  262-  276 (25.23/15.05)	FVIDNEFEFDVMSFV
  284-  298 (26.70/16.34)	FLIDLRLLFNPAPVV
  304-  315 (19.51/10.02)	FFIQLK...QQADMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.12|      22|     158|     339|     360|       8
---------------------------------------------------------------------------
  339-  360 (38.43/22.96)	ILRSQAAALARAGWAGSLKVEP
  495-  516 (39.69/23.95)	IMRPASALAARAEHAFNLGREP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.33|      43|     158|      30|      78|       9
---------------------------------------------------------------------------
   30-   78 (60.43/55.23)	NPKDAS.INGASASNTS.LAQYSDLPPEiaHIGPEQynALStlLLRISQES
  191-  235 (67.90/42.16)	NPDIATaLQVLSTGKASwMPSLGYIPPE..PISSDQ..ALN..LLRYMNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      13|     250|     442|     455|      10
---------------------------------------------------------------------------
  442-  455 (19.11/14.34)	SDIlRSTKESLRTG
  699-  711 (24.81/14.16)	SDI.KITCEGLRAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.26|      25|     250|     623|     689|      11
---------------------------------------------------------------------------
  530-  555 (40.76/ 6.48)	TLAGLiQRNA.QQLGWQVVARQALKPQ
  627-  652 (36.50/66.26)	TLASL.ERVAiQLLSFRITARQLAKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.59|      21|     158|     950|     980|      12
---------------------------------------------------------------------------
  928-  948 (39.07/12.64)	DNLRPKDPNVLPTPERGQ.GHR
  951-  972 (32.53/33.25)	DNLQEKLKELFSGKATGWfGTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21572 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNHTAADAATPSRDGTNMKRNHDGSLINGNPKDASINGASASNT
2) SCKMEGGYVAPPPLERPAQQAQNPNQALPQANGAQQGNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQARMHQQQQQARQQQARKQQPNQQHNPRAQQQNGRPQQIPNRQQQMQQQGRGGRPGQNQNNVIEID
1
995
44
1131










Molecular Recognition Features






MoRF SequenceStartStop




1) QARMHQ
1066
1071