<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21571

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMASLPGFTTNFPAGYPTFQTQGGTFARGSTSSGGSPSIPNPSAEPHFDIFEWHPAYQSCQRYFLDHAQHDNGVQAVCALINICLPFQWTQGPLMNASGPLPHSSGPAAYNMPWPRPGPVTNSRGQPAPAWVSLVPFIRRLVITGMDSSGIMHGFFGEDWRKGVGPMHECERRNYLFAAKSVGWAKVKCQYDMSPHESVPFLKPLQEVQLAEIEGAEKTWSQWLAMEDWMEWSAFLDRCLERRVQPDVFAAAVAQLHAKSPLPGRKIAALVLRPRVAGTNSIDPRAIGFLEQLLALKKVDVSDVLTLTFLYSKDRLPVKAGEEKTPKDAQWNNPPEVEEVIFHRLHKDFAAEERPVNNAEGLRTLIVITRWMQAMVTSHTSDTMIQAMAGIQQPQQQSINVREGLAMLVIGIVENSKILRILNNPKGKDVRKAFTQSLSSFIPFLSNNSAGSQTSLSLANRLEMSQKQHDFYEKLPSVNGQGNENAGLEVAALQLDAVMELPQANTRAGLYIFLNALLVARPLTDDFTIINHLHTRYKLEAQNMATDLITAAFDILANAMYRNEPSQFLFCLKSFLINKVPMLLTQISGSIFPMTVEMCITQALSHVDPNAFPSFSQGFDDIMGSSNSLSDVRQDYLNACVLHGLIQAGTVERLLGEAPMQGPPAKRYEKKELLSQCKANFDKISLYIDELENLDGNAGAIVAAVTDFIAHLCETQTTMYLKQLSCLIFKKPQAMDVMLQFTSPASILRPLCQFLEDWHYDSDQGEYQPVYDEFGAILVLIMAFIYRYDLTYHDIGIGHDTFIAKLLKRGHYSMLPDELSEEQGKHLGNWLKGLYDSDKEGLSNDVFASCRPQDFYLIVPTLFRQTVVACSTGVLSFESVKGGLEYLGETFLLPSLIEGLIWMANYALLQTHNDLDAMIRIFNEIILSTPSSGDAQAMHSTIIAMVSSRLEKCFRTLQRRDPNRTTLEPFIQAIKVHTHYERTVFATLKELDQWTNAPNSTLNNSLRHTVQQLSQWASPASMQPNPPSYTHRQIYASLKMLGATCTLRAIVEEVKTQTDAGNGAAALDVAVSIICAPTVEDSPIAVNWVGSSISAPAPQRTHMNLREILGQEFDSAANLFATDPPTAETIVRLHRRVEAHFASLGEHGLQAPPINIPSVNIADMQSQTISDDLNRAIDDAAAATIVDDISNMDNKALQRSMDELTGAEGLDLSNIGMGNGDSGAGDMSTDLGNLPDLDLGDMGGMGMDMDMNMDMGGGGGGDDDWGLDFDNM
Length1271
PositionTail
OrganismStemphylium lycopersici
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Stemphylium.
Aromaticity0.08
Grand average of hydropathy-0.171
Instability index44.80
Isoelectric point5.14
Molecular weight140344.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21571
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.21|      16|      68|     157|     172|       1
---------------------------------------------------------------------------
  157-  172 (33.80/22.30)	EDWRKGVGPMHEC.ERR
  226-  242 (29.41/18.41)	EDWMEWSAFLDRClERR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.27|      19|      25|    1209|    1231|       2
---------------------------------------------------------------------------
 1209- 1231 (27.10/26.13)	LDLSNIGmGNG.DSgagDMSTDLG
 1236- 1255 (36.16/19.62)	LDLGDMG.GMGmDM...DMNMDMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.38|      30|      74|     737|     770|       3
---------------------------------------------------------------------------
  737-  770 (53.99/50.02)	MLqftsPASILRPLCQFLEDW...HYDSD.QGEYQPVY
  813-  846 (46.39/31.97)	ML....PDELSEEQGKHLGNWlkgLYDSDkEGLSNDVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      15|      67|     107|     140|       4
---------------------------------------------------------------------------
   84-  101 (23.29/11.89)	LPfqWTQ.GPLMNASGPlP
  111-  126 (28.96/39.86)	MP..WPRpGPVTNSRGQ.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.55|      17|      69|    1014|    1030|       5
---------------------------------------------------------------------------
  992- 1009 (27.28/14.88)	QWTnAPNSTLNNSLRHTV
 1014- 1030 (35.28/21.55)	QWA.SPASMQPNPPSYTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.13|      21|      54|     588|     608|       8
---------------------------------------------------------------------------
  588-  608 (39.16/25.55)	GSIFPMTVEMCITQALSHVDP
  643-  663 (33.97/21.11)	GLIQAGTVERLLGEAPMQGPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.60|      25|      27|    1100|    1124|       9
---------------------------------------------------------------------------
 1100- 1124 (42.71/25.18)	THMNLREILGQEFDSAANLFATDPP
 1128- 1152 (39.88/23.02)	TIVRLHRRVEAHFASLGEHGLQAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.57|      25|      30|     933|     960|      10
---------------------------------------------------------------------------
  936-  960 (43.37/38.08)	AMHSTIIAM.VSSRLEK.CFRTLQRRD
  965-  991 (34.20/19.32)	TLEPFIQAIkVHTHYERtVFATLKELD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      15|      27|     461|     475|      13
---------------------------------------------------------------------------
  461-  475 (27.91/17.93)	LEMSQKQHDFYEKLP
  487-  501 (24.34/14.71)	LEVAALQLDAVMELP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21571 with Med5 domain of Kingdom Fungi
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