<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21566

Description Ubiquitinyl hydrolase 1
SequenceMDNVLNEQFGRVEKALTTLVDSIAAYNPVTQGAIDLVAADEQLSEGLDQLARHQENHARIQTLRAEADALEEQLKTSVKKLAELRHELFDTPITSFPEESRAVPFDELLQYATNISRYTVPPTYRERVPTTEKDKDEEDAVSNGAPTNGVNTPAIGPEATDSANDAPEGQKQAEDADGAVPDITAEEEEWLKKLKASNLAWYPWPSTDKIRSGNLYRLSFWREKGNNLDEFNVPAYLEEQRKKALGEMPPAEESPKIIPDTAPAEQPQPQPETAKPKAQPLSAFTGFDDLDEIRARLFSNFATRREPPTHSLTINTKMAGKTRKRERDAEPVEKVEEAPAKRRRQTNEDQVKLSKLYADLAAEEDDVRLEAAKSIIVKFSPESKPAAKEVEDALIRLIKGLCSQRKAARVGFSLTLTELLRQIFGAKKNEMEDLDLDVASIIKMVEEKTKAKGNVPGKERRDHTIGKLFGFKAIMQSSILIEPELSLDCWNKLLDQVYRMARDIPWLREECGMVLVEAVRSLQGQPQYQKCAEEVLERLNAFKLVSTPEGVAVWLTVQASYPKALPEGVWHGKDPLSKKERSRLAKILKEDFNKSESEDGKNETTKTGTTNPNPSFTWDLVFAEILRRDESESGDTKNKAEFPQFWIDTVDGNLFSSSASHERKAWGFKLLSSLITRVPDWIVPALFSPNLMRTLINQSKKEDRFLHSAALAALNSIQLRVDQEDGTALPVFVALTSKNGSIEFDRITKTKTLEQILASADDKSLMKIVRHLKSLILRPESEDQTIVDSRRQAIADLLLNSVKHYKRYEKFNEKVFKKDVAHRQEGRASEERKSNWLREALETLVECAYFVSTKNAETKKIPLPPISDRSRTIFQERLSSCLTKLLDAKLGGRSDVALMVVDMIKTRSGKSSKLELAFKADASILSTVKQASKTLDAISASGSIAGNEMAAQGFMLLYSLTLLQVYNGEGDAVMMLDDLDASYKAFEASHKSSSKKQKSSASDGQNAFVEIVLSFLGNNRTLFRRIGEEAFSIFASEISVDGLQSLLEILDTEENLEGQKELFNQDDEDAEEGESSDDDEDEEDSDVEMIDGEGSNDEAASDASGSESSEGDSDSDDEDDVEDAELTQFNNMLAMTLQTSKLNADGDAADETSDESDMDDEQMMALDPHLSKIFKERSKTTSKKKEREDAKQNVVQFKSRVLDLLAIYMEKQYSNPLTLDILLPVLRRTRANANKQTADKAAKMLKTFFDTRTKRKAPLPKPENIEGVWALLRGIHDEAKLGNGAKVHADACGSASLHVVKVLVGLDKANYAGVVDIYAETQKQWFADKKSPLQPVLFTQFQNCNPVGPKLVYESKIFNFSNILLMVLAQTQWIIPVMFTCPAQSVYREDCTQCFDSIDDPTGLDVCLYCFNGGCTSERNHALLHVSSKNHPLVLNIKRTRKRADRDEPPQKMTKLAVAAETESDRYDTTTQVKCYECGVDDVDKSSGKLPDIVDAVLKANTFAKQQEVKAWEQELTACEHTLCLEQDAARQIESQKLGHCSECELNENLWLCLSCGNLGCGRQQFGGVGGNSHGVGHTKSTGHPVAVKLGSLTADGTADIYCYACDEERIDPELPDHLAHWGINIKDRVKTEKSLTEMQVEQNLRWDFAMVTEDGKELQPLFGPDFTGLKNLGNSCYLNSTLQALFSMPEFKERYYLPDQGPPDAALPAEDLETQLRKIADGMISGRYSKPESDVITNEHSPEIPHQRGLAPAMLKHLIGRGHPEFSTMRQQDAFELLLHILKLVSRSQHVAPHKDPVDAFRFAMEQRLQCVGCKRVRYRTDEQENISIPVPIRRMPKESQMDVTDSNGKKEEKEEFEPVSLKECLDIFTAEELVELTCSACGSKEGFTKRNMFKTFPSVLAVNARRFELVNWVPTKQDVPVIVDDEPFSFDAYRSKGLTEGEEVLPDDMDTGAAVGSSGKWTPNEAALSMLEAMGFPRVRCEKALHATGNEDAEAASNWLFAHMEDADIDDPVDFNAGSGGGAAATSTIDPEKIENLGAMGFSAPQARQALKETGGDMERAVDWLFSHPDAPGDFDEGGSSEAAADATERALAGSDKLPAKFQLQSIVCHKGSSIHAGHYVAFVRKQLPSEPSPSWVLFNDEKVAKAADVDEMKKFAYVYFFRPLLDHYNKPRNVGSMAKGDSDVGTGLVGAPACGDVMKLQIRVDPNNNTISDVKFKTFGCGSAIASSSYLTELVRGMTLEDASRIKNTEIAKELCLPPVKLHCSMLAEDAIKSAISNYYTKNPNARQTDLGGKSAPLPKHTATMQGDNAAPAIRFKRRKTTHPKRVVTEDDAAPVSAAHSPDAGALQNAPSPPKEADDEESVPNLKEILRNRKRLRDRLKESGRKVEAPRTELVHTDAPPPDQYTGRFVAQTGQVVDRDDKQMSEYVEARMAEKNYRQYGWPIPQHLQTSVAAIAPDLRHTFASRPSAQARVGTDSPADKEHSNRLAAGQGKLQEVDLGPEASARIEQAWKRWDNGEPEPSASKARRDKYGYAWRKPRAGGKTDEDKKRDQMVEAVLREAKLDYFDAPAPSNPPTNNSTHANTDDALAEQFRAEYLESMEMKQQQIAARKPAQTANKGAPPPITGPKMGGSKSARARMHKLQQEELAKKKR
Length2655
PositionMiddle
OrganismStemphylium lycopersici
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Stemphylium.
Aromaticity0.06
Grand average of hydropathy-0.605
Instability index47.03
Isoelectric point5.32
Molecular weight295003.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
mitochondrial matrix	GO:0005759	IEA:UniProtKB-SubCell
nucleolus	GO:0005730	IEA:InterPro

GO - Biological Function
2 iron, 2 sulfur cluster binding	GO:0051537	IEA:UniProtKB-KW
DNA binding	GO:0003677	IEA:InterPro
iron ion binding	GO:0005506	IEA:InterPro
nucleotidyltransferase activity	GO:0016779	IEA:UniProtKB-KW
thiol-dependent deubiquitinase	GO:0004843	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
iron-sulfur cluster assembly	GO:0016226	IEA:InterPro
protein deubiquitination	GO:0016579	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
ubiquitin-dependent protein catabolic process	GO:0006511	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21566
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.53|      55|      63|    1970|    2030|       1
---------------------------------------------------------------------------
 1970- 2030 (84.74/63.82)	LSMLEAMGFPRVRCEKALHATGNeDAEAASNWLFAHmEDAdiddPVDFNAGSGGGAAATST
 2036- 2090 (99.79/57.00)	IENLGAMGFSAPQARQALKETGG.DMERAVDWLFSH.PDA....PGDFDEGGSSEAAADAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     436.93|     154|     391|     722|     896|       2
---------------------------------------------------------------------------
  722-  896 (206.18/185.18)	DQEDG......TALPVFVALTSKNGSIEFDRITKTKTLEQilASADDKSLMKIVRHLkSLILRPESEdqtiVDSRRQAIADLLLNSVKHYKR....YEKFNEKVFKK....DV...AHRQEgRASEERKSNwlREALETLvecAYFVSTKNaeTKKIPLPpisdRSRTIfqERLSSCLTKLLD.AKLGGRSDV
 1116- 1287 (230.75/145.07)	DDEDDvedaelTQFNNMLAMTLQTSKLNADGDAADETSDE..SDMDDEQMMALDPHL.SKIFKERSK....TTSKKKEREDAKQNVVQFKSRvldlLAIYMEKQYSNpltlDIllpVLRRT.RANANKQTA..DKAAKML...KTFFDTRT..KRKAPLP....KPENI..EGVWALLRGIHDeAKLGNGAKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.42|      24|      63|     203|     230|       3
---------------------------------------------------------------------------
  203-  230 (40.88/29.92)	PWPSTDKIRSGNLYRLSFWrekgNNLDE
  269-  292 (43.54/22.78)	PQPETAKPKAQPLSAFTGF....DDLDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     469.62|     218|     326|    1320|    1557|       4
---------------------------------------------------------------------------
  310-  409 (87.30/42.12)	HSLTINTKmagKTRKR.ERDaEPVEKVEE....APAKRRRQTNEDQVKLSKLYADlAAEEDDVRLEAAKSIIVKFSPESK.PAAKEVEDALIRLIKGLCSQRKAAR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1320- 1430 (125.06/81.74)	.............................................................................................................................................vgfsltltellrqifgakknemedldldvasiikmveektkakgnvpgkerrdhtigklfgfkaimqssiliepelsldcwnklldqvyrmardipwlreecgmvlveavrslqgqpqyqkcaeevlerlnafklvstpegvavwltvqasypkalpegvwhgkdplskkersrlakilkedfnksesedgknettktgttnpnpsftwdlvfaeilrrdesesgdtknkaefpqfwidtvdgnlfsssasherkawgfkllsslitrvpdwivpalfspnlmrtlinqskkedrflhsaalaalnsiqlrvdqedgtalpvfvaltskngsiefdritktktleqilasaddkslmkivrhlkslilrpesedqtivdsrrqaiadlllnsvkhykryekfnekvfkkdvahrqegraseerksnwlrealetlvecayfvstknaetkkiplppisdrsrtifqerlsscltklldaklggrsdvalmvvdmiktrsgkssklelafkadasilstvkqasktldaisasgsiagnemaaqgfmllysltllqvyngegdavmmlddldasykafeashkssskkqkssasdgqnafveivlsflgnnrtlfrrigeeafsifaseisvdglqslleildteenlegqkelfnqddedaeegessdddedeedsdvemidgegsndeaasdasgsessegdsdsddeddvedaeltqfnnmlamtlqtsklnadgdaadetsdesdmddeqmmaldphlskifkerskttskkkeredakqnvvqfksrvldllaiymekqysnpltldillpvlrrtranankqtadkaakmlktffdtrtkrkaplpkpeniegvwallrgihdeaklgngakvhadacgsaslhvvkvlvgldkanyagvvdiyaETQKQW.FA....DKKsPLQPVLFTQFQNCNPVGPKlVYESKifNFSNILLMVLAQTQWIIPVMfTCPAQSVYREDCTQCFDSIDDP..TG......LDVCLYCFNGGCTSERNHA...LLHVSSKN
 1431- 1557 (129.49/101.78)	HPLVLNIK...RTRKRaDRD.EPPQKMTKlavaAETESDRYDTTTQVKCYECGVD.DVDKSSGKLPDIVDAVLKANTFAKqQEVKAWEQELTACEHTLCLEQDAARqiesqklgHCSEC.......ELNENL..WlCLSCG.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1602- 1763 (127.77/67.14)	..................................................................................................................YCYACdeeridpELPDHLahW.GINIK................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................drvkteksltemqvEQNLRWdFAmvteDGK.ELQPLFGPDFTGLKNLGNS.CYLNS..TLQALFSMPEFKERYYLPDQ.GPPDAALPAEDLETQLRKIADGmiSGryskpeSDVITNEHSPEIPHQRGLApamLKHLIGRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.06|      33|     328|    1895|    1928|       7
---------------------------------------------------------------------------
 1895- 1928 (53.65/51.77)	FKTFPSVLAVNARRF..ELVNWVpTKQDVPVIVDDE
 2219- 2253 (52.42/43.34)	FKTFGCGSAIASSSYltELVRGM.TLEDASRIKNTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.97|      19|     903|     165|     183|      11
---------------------------------------------------------------------------
  165-  183 (33.61/20.33)	DAPEGQKQAEDADGAVPDI
 1069- 1087 (32.36/19.23)	DAEEGESSDDDEDEEDSDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.25|      22|    1792|     567|     590|      12
---------------------------------------------------------------------------
  567-  590 (34.91/27.25)	EGVWHGKDPLskKERSRLAKILKE
 2364- 2385 (37.34/22.65)	ESVPNLKEIL..RNRKRLRDRLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      15|      15|      90|     104|      13
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   90-  104 (26.85/15.59)	DTPITSFPEESR.AVP
  106-  121 (21.12/10.60)	DELLQYATNISRyTVP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21566 with Med4 domain of Kingdom Fungi
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