<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21561

Description Uncharacterized protein
SequenceMIPHPSSTGLQTWTSQHRASGTADRSSMAVAPAPSSAQQLIDLSSDGPTENEHPHKRPRLDTTVSGLSGDGRTPSSRSATTGPTPNRPSAVSGRGRPAYSFQELVADTYGGNVFAGNVTPGSQTSKPPSPPPFPVRPWTHTSARLSQVENEGLSNNIRGRVVQTVPYHPETPEIAPSLTREKIADYAPWSRTGNHPEDRLSDLNVKAGNFDRVPGPNTNSDIQSHASKLSSQLKNHSSLQLLSSVFAAALEKRQINEKISSTSTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLAKCVGANEIRAFKRKGTSGSLSQGLETKWVREWTLSVQQFTAGVISACGKPDWRNKMTYAVRLAARLFYEHLLDQDYYLDWYLSSMEGSSLDAFPIWLAMLSIYWGSLVRFRKRGRRLAETLLEKLREATSSDFKMNLQPLIDRISLLVRRLCRENSPCLILPRSWDRYQDVVASSLSDDSREKAILQSLILRNARVQRPGTCCPTRQRSPQEQVIKLLDASRDSCDMCSLSSSCLNLVPDRQELVSVLLRWAASSFRQGLVRVYIAVRLFRKWKRSGMDIDACIFPFLTQASIEQSTSSMTNVYHIVVELIRSQTFSVGRYLQWLVARGAVEQYRQHYSPASSVPVDIALLSHIPVARLPRHLRNLRDTLMARAGLSSSEAEVLHSVKADLKQRLPSLLGKDGFHMNINYDQHNLSWSIKADVSQWIRAAVSEHYENGSAYPKIYENSVEVSSLTQEEFLVVRSVLEQYGDLSMLADILIDASNSDDIRLLTCAVDTLNRHFECFTIIGALGDMFRSFYEAFLRVKTNGQPLYDLAYSMAEVGHRLPEEVNSLVLLRQELCRADRNLALAACSPVSDHMAETLNDSSPSFNEDMDHFLSSGNSMDEMTMVLVFQKLIQQLASYNEKIPSKPGSVCRHLVQLRSFNSKHFDLLLVQWLETILKSASRPNLSRLLHPLVGIGCVTLPAFATLMNKLLQSGSLQPANSVLPESLVDFLELLVPNYSAEPLYDFLAYRFRIAQEEFLHGHSHEALALLKDAVPHMTLGAQNLVSSVPCVVPLLSEIIVRRPEAATLDSIRALMKVNPVFLPVVRKSLDHLLSDHQSNPDFLMQTAMTINKTNHLSLPLCQLKLQILFDEKNDDSIRNSIVDLMYTSAVADVRTGNTYWLDLVSTMGQEAAEQLRQRAEKDFFAVAQPESMEKDSENEKLGLQDNARVYLAIVDGLAYSIPEEGVSAVAPVLVERMNALLQKLFTMHMNVRTWTEQRSRSSQEAMTRSLSGSEENFVFWLTAMLQMIRIHRAAFDLPSSGNHRLGAYVDLSRLLIIICCLALSRTPLGLTVQPRLDLSASSYFLASAKEVRAGNTIQTYALDIASSLVDSLPDEARQHCANFIKERFPPALNVQNDPRLQFLFGPVAENFGNMGGALPSSVSVSSPAATLTPSNNPVSAATVAGGNAIEDPLALNNRLRVQSRGRVIGSYPVRPWEMLEEAAPVVGANDTAIDLNLFGARKVRDY
Length1556
PositionKinase
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index48.61
Isoelectric point8.37
Molecular weight173053.37
Publications
PubMed=28649280

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21561
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.00|      66|     134|     649|     716|       1
---------------------------------------------------------------------------
  649-  716 (106.84/82.58)	QWLVARGAVEQYRQHYSPA.....S...SVPVDIALLSHIPVARLPRHLRNLrdTLMARAG.LSSSEAEVLHSVKAD
  784-  854 (94.00/65.54)	EFLVVRSVLEQYGDLSMLAdilidA...SNSDDIRLLT.CAVDTLNRHFECF..TIIGALGdMFRSFYEAFLRVKTN
  859-  909 (55.16/34.81)	...........YDLAYSMA.....EvghRLPEEVNSLVLLR.QELCRADRNL..ALAACSP.VSDHMAETL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     495.87|     125|     362|     994|    1118|       3
---------------------------------------------------------------------------
  994- 1118 (205.77/119.04)	NLSRLL........................HPLVGIGCVTLPAFATL....MNKLLQSG..S...LQPANSV..LPESLVDFLELL..VPNYSAEPLY.....DFLAYRFRIAQEEFLHGHS.HEALALLKDAVPHMTLG..AQNLVSSVPCV.VPLLSEIIVRRPEAATL
 1138- 1289 (128.61/71.48)	SLDHLLsdhqsnpdflmqtamtinktnhlsLPLCQLKLQIL..FDEK....NDDSIRNSivD...LMYTSAVadVRTGNTYWLDLVstMGQEAAEQLRqraekDF....FAVAQPESMEKDSeNEKLGLQDNARVYLAI...VDGLAYSIPEEgVSAVAPVLVERMNA...
 1360- 1481 (161.49/91.75)	DLSRL...........................LIIICCLALSR.TPLgltvQPRLDLSA..SsyfLASAKEV..RAGNTIQTYALD..I....ASSLV.....DSLPDEARQHCANFIKERF.PPALNVQNDPRLQFLFGpvAENF.GNMGGA.LP..SSVSVSSP.AATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.45|      14|      24|     938|     952|       4
---------------------------------------------------------------------------
  938-  952 (20.20/18.42)	VFQKLIqQLASYNEK
  960-  973 (26.25/18.26)	VCRHLV.QLRSFNSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.72|      13|      24|     158|     170|       5
---------------------------------------------------------------------------
  158-  170 (25.17/15.19)	RGRVVQTVPY.....HPE
  180-  197 (20.55/10.99)	REKIADYAPWsrtgnHPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.65|      21|      23|     334|     354|       7
---------------------------------------------------------------------------
  320-  338 (25.59/13.69)	..GRAVWLAKCVGANEIRAFK
  339-  359 (35.56/21.93)	RKGTSGSLSQGLETKWVREWT
  363-  378 (22.50/11.14)	QQFTAGVISACGKPDW.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21561 with Med12 domain of Kingdom Fungi
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