<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21558

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGDATTNFCAITGFSVIYWRIYTEEATTGNPEITPNSGYNILRHLSRLKDLEIQLRNSDCLVSCYPRRLGLWIFSPTPGFESLSPLTRDPAAPGLKESTKLNIGTSTLKVSAFGSITAVDLIRSLSTDGFTSVAGAPGQTTRPPGASVNAPRSGDAYANSMAIYASFITAMAGAIGLQLVKRHNAIPLGARTFYTAVERSFYDNPAISDDDVDSIPALTTLKIELTQTGKIVVALHTVHQDGISRLKEPGTTEINTVNIQNNMDVWLAPNGTVARLITVNTAQSAVFAPKQAKSEGAARQITEAKQRVWKATVLEWLNNVGLPVDHPEDEHWIEVEVSEPFYARLAAEHLRQMDDSQSSSPLKRILWPSRYCFRRTKIVSSNITEKSSQLAYDSEEPLHFAETWLETATARHEKPKGDPSNIQETSQIESVAGTVRFEVPEKIESLARVIHYPDLQNASSVYPTPPDGALAPGINQINSDALGPDAQDLGLSHTPAGETPMKQQENVRKTSSDNPSFEHMNAMEVGTGLYDTNDDDELFSGMNDKDFGSKGITDADFSFFDDDDDEMNDFLNDKPDTGTAHEDIPQSIPGESNEFPIAQAEIEESQAPDESVSEQDEMQQSIDVEASSLSQIPVKQSSTTPPNIASHEATPVPLENVISAPLSPTDIKQMLFSKRDARPQDGERRTSASSNAGFERKQSRYNAVSFKRGLGLDQKYANAGRFFFTVNKDGNENINKSPGIPTIGFPGLRKLGLRPSVDDVNTPRQISSEQSIQRTDSASSDESCLDSSDDDSEDETSPFRLATLKRKRPLSEAEKSTTSSMEKLSITSEVESHVSKEDTSIFLGNFFSVFTDWSLVGYFSAKQCQVSPVTSRKEDQMQIAQLMVDQLTQSSLSHRIEGWESDPSLDYETFGLHTFLDDSMSLGENERLDLKSYVTIHDSVQSTAETPSARPNPPRREVKGSITKIAPSHLRIHRGRDYLEVLSTSMPFWETFGLEPASGRKDVSAYCICPELAKQETDAFMTRLGLLYSGCNLGKHIRGDIIEKFKNGIGLWNIAKGDGSYARTMQTLRSLCEDLASALSKAPQTGENFVIYMINPFSHGGAFVDICSNFLHLFHKYVGEVDKNQDKGQLNELVLQIVPLNFVFSPTSMVVPPQPQYLSLALEVYSRCPPKDASFGIIGYAPPVVLADTVPKAINFRSTSENFSPFQEGRCLHVAISRSVDQRWISVAWTNNSGSCQIAMSYCVRARGSNVNRIISEVRQEIWEATKDLMERTQTRWKVLLVRTEPIDQEEIDAWTGFAERYNQAKALPVELTLFSVNIAPGLRLEPSTTQFSVNTINPFVSTPVATPYGGVSSPDQLGAATPASGGQGPTTMTYSTAITPTDTPPVLVEADSDAVLIDACDESWAVVLSHRLSNSAYLTEYKPALVSGYLLRRKGVNDSQGVSAMSLNLVYTSRPPALHEAVLREALINYRDLATLAXAKGTLHVQHNTLPWHIATAVKGQELLSFVL
Length1512
PositionKinase
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.08
Grand average of hydropathy-0.382
Instability index51.10
Isoelectric point5.05
Molecular weight166098.85
Publications
PubMed=28649280

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21558
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     121.33|      25|      28|     527|     551|       1
---------------------------------------------------------------------------
  465-  483 (23.98/10.93)	...............YPTPPDGALAPGINQI.NSD
  496-  528 (25.17/11.89)	HTPAGetpmkqqenVRKTSSDNPSFEHMNAM.EV.
  529-  551 (37.28/21.64)	..GTG.........LYDTNDDDELFSGMNDK.DFG
  557-  581 (34.90/19.72)	DADFS.........FFD.DDDDEMNDFLNDKpDTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.66|      12|     293|    1161|    1173|       2
---------------------------------------------------------------------------
 1161- 1173 (19.61/14.65)	LSLALeVYSRCPP
 1449- 1460 (24.06/13.31)	MSLNL.VYTSRPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     426.27|     140|     242|     937|    1100|       5
---------------------------------------------------------------------------
  937- 1100 (208.38/243.50)	VTIHDSVQSTAETPSARPN.PPRREvkGSITkiapsHLRIHRGRDylevlstsmPFWETFGLEPASGRKDVS.AYC..........ICPELaKQE....TDAFMTRLGLLYSgCNLgkhIRGDIIEKFKngIGLWNIAKGDGSYARTMQT.LRSLCEDLASALSKAPQTGEnFVIYMINPF
 1187- 1343 (217.89/177.67)	VVLADTVPKAINFRSTSENfSPFQE..GRCL.....HVAISRSVD.........QRWISVAWTNNSGSCQIAmSYCvrargsnvnrIISEV.RQEiweaTKDLMERTQTRWK.VLL...VRTEPIDQEE..IDAWTGFAERYNQAKALPVeLTLFSVNIAPGLRLEPSTTQ.FSVNTINPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.60|      30|      31|     586|     615|       6
---------------------------------------------------------------------------
  586-  615 (48.92/25.64)	DIPQSIPGES.NEFPIAQAEIEESQAPDESV
  620-  647 (44.67/22.80)	EMQQSIDVEA.S..SLSQIPVKQSSTTPPNI
  652-  672 (21.00/ 6.94)	ATP..VPLENvISAPLSPTDIKQ........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     306.69|     105|     150|      96|     219|       7
---------------------------------------------------------------------------
   96-  219 (148.87/134.23)	PGLKESTKLNIGTS.TLKVSAFGSITavdliRSLSTDGFTSVAGAPGQtTRPPGAsvnAPRSGDAyanSMAIYASFITAMAGAIGLQL..VKRHNAIPLG.ARTFYT..AVE..RSFydnpaisDDDVDSIP
  252-  364 (157.82/98.13)	PGTTEINTVNIQNNmDVWLAPNGTVA.....RLITVNTAQSAVFAPKQ.AKSEGA...ARQITEA...KQRVWKATVLEWLNNVGLPVdhPEDEHWIEVEvSEPFYArlAAEhlRQM.......DDSQSSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.31|      22|      77|     681|     702|       8
---------------------------------------------------------------------------
  681-  702 (37.27/21.36)	RP..QDGERRTSASSNAGFERKQS
  757-  780 (30.33/15.90)	RPsvDDVNTPRQISSEQSIQRTDS
  791-  811 (27.72/13.85)	SD..DDSEDETSPFRLATLKRKR.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21558 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQNASSVYPTPPDGALAPGINQINSDALGPDAQDLGLSHTPAGETPMKQQENVRKTSSDNPSFEHMNAMEVGTGLYDTNDDDELFSGMNDKDF
2) GVSSPDQLGAATPASGGQGPTTMTYSTAITPTDT
3) KGITDADFSFFDDDDDEMNDFLNDKPDTGTAHEDIPQSIPGESNEFPIAQAEIEESQAPDESVSEQDEMQQSIDVEASSLSQIPVKQSSTTPPNIASHEATPVPLENVISAP
4) LGLRPSVDDVNTPRQISSEQSIQRTDSASSDESCLDSSDDDS
5) TDIKQMLFSKRDARPQDGERRTSASSNAGFERKQ
457
1354
553
754
668
550
1387
664
795
701










Molecular Recognition Features






MoRF SequenceStartStop




1) EIAEKKPGKAAKDKGQRTN
2) QSQEVPKES
1047
1073
1065
1081