<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21557

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLVMDDVSASASRDWGDSYNHHESNGNSTVVRGAHQVDSNGKSDNPQQVNGFKGDDGKGQGFNTAMVLKHGQSSVMPDSVQGLWAPPLMHITQGFFPYSQLVNRAVQQCYNDLCDVITELADSTQPQQSSSANGKPDPAAMQKRIRILEFAQTKRTEFIKLLVLSQWSRQAVDVSKLIDLQNFIRTRHFAYQTAVQRVADMKRDLVRAQVANPDLQTALEVLTMGRVSNMPEFGYKPPKPLSSKRLLATLQKINRIISTRLVTSDTIPSSLNDYRVHDGRATFSVQGEFELDLSIAEEDVTSQFYFIDIRFLFTPSSPIPKGRFFNELDSQINSILKTKGLSGCFDFIHNLVLVNKINILFKQAISLSRGQWIGALRVELLHRILVVHYWPDKSGPKSWLEIGAHSGRQQRQKVSYLGLRWVRDGKECESAQIHFDTETLSMESILRSVIAIHSAHILRAVYERLCTENLFANHRLSISMQMSKTEPGNCRLNVQLTETRYLNASLEPVSGTMCIHTIPSLLCRLDKGSASDDDFVNRISRLRCIAAMEEIESDAKIFGWESVDHRKFKVDIRRVFPSNILRASFFRNRVWGSSWIIAATTSLSGDDWWILRLKARPLSYPDGSGHARVVAGGFSVQSTRVSSGDQILSPRESRYHFPDLDYSLTGALVMYSNALWLSELGYQDVLPPMDQLQLGSRLEVPCLYLKFDIAKLPRQLRITPLEGAQSKSYVRETFTISYHGIDFRTKNAIVVAHGRFHTPLRKMGLKRLKLDDCVLLRRGGTAFAMRFLVAPGQPIMTDLFERIQRLNIALSLFHTLQQSKITVKSVSLSNLSFVYAPREGFEANIVVRLDRLGHAPDLDPAIVRLRDESLFRLRLDISFNNLSPHNRIKQSLGMILNRSGPGNGVQCVLQLLKLTLPVLRALDRLVTEPQHNSALRVQVSIRGAQTFQIHYFGLRFRFLVNALQRRDKIIWTLKDISSSEGQRDVEQAVEAKLQEKIYRGKGDGWQGLGNGAVAEVDQVGNLLSELDSCFADLTPPAALPAAPSEIAEKKPGKAAKDKGQRTNGTSKINRQSQEVPKESDVIMID
Length1087
PositionTail
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.08
Grand average of hydropathy-0.269
Instability index42.78
Isoelectric point9.36
Molecular weight122158.41
Publications
PubMed=28649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     283.68|      82|     261|     243|     345|       1
---------------------------------------------------------------------------
  243-  327 (121.87/90.07)	LSSKRLLAT.L..QKINRIISTRLVTS.....DTIPSSLNDY..RVHDGRATFSVQgEFELDLSI.AEEDVTSQFYFIDIRFLFtPSSpIPKGRFF
  369-  410 (43.14/35.40)	LSRGQWIGA.LrvELLHRILVVHYWPD.....KSGPKSWLEI..GAHSGR..............................................
  498-  588 (118.68/72.68)	LTETRYLNAsL..EPVSGTMCIHTIPSllcrlDKGSASDDDFvnRISRLRCIAAME.EIESDAKIfGWESVDHRKFKVDIRRVF.PSN.ILRASFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.23|      32|      36|     591|     624|       2
---------------------------------------------------------------------------
  591-  624 (52.48/38.16)	RVWGSSWIIAATTSLSGDDwwILRLKARPLSYPD
  630-  661 (56.75/32.54)	RVVAGGFSVQSTRVSSGDQ..ILSPRESRYHFPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.62|      38|     149|      49|      89|       3
---------------------------------------------------------------------------
   49-   89 (64.89/60.35)	QQVNGFKGDDGKGQ....GFNTAM.VLKHGQSSVMPDSvqGlWAPP
  198-  240 (59.73/43.60)	QRVADMKRDLVRAQvanpDLQTALeVLTMGRVSNMPEF..G.YKPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.59|      12|     104|     762|     773|       4
---------------------------------------------------------------------------
  762-  773 (21.29/12.83)	LRKMGLKRLKLD
  867-  878 (21.29/12.83)	LRDESLFRLRLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.01|      24|     149|     881|     904|       5
---------------------------------------------------------------------------
  830-  857 (34.69/25.23)	LSNLSfvyaPREGFEANIVVRLDRLGHA
  881-  904 (43.32/33.68)	FNNLS....PHNRIKQSLGMILNRSGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.13|      39|     217|     694|     740|      10
---------------------------------------------------------------------------
  694-  740 (58.20/51.52)	LQLgSRLEVPCLYLKFDIAKLPRQ...LRI.TPLEGAQsksyvreTFTISY
  911-  953 (57.93/33.38)	LQL.LKLTLPVLRALDRLVTEPQHnsaLRVqVSIRGAQ.......TFQIHY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21557 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PAAPSEIAEKKPGKAAKDKGQRTNGTSKINRQSQEVPKESDVIMI
2) RDWGDSYNHHESNGNSTVVRGAHQVDSNGKSDNPQQVNGFKGDDG
1042
15
1086
59










Molecular Recognition Features






MoRF SequenceStartStop




1) EIAEKKPGKAAKDKGQRTN
2) QSQEVPKES
1047
1073
1065
1081