<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21557

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLVMDDVSASASRDWGDSYNHHESNGNSTVVRGAHQVDSNGKSDNPQQVNGFKGDDGKGQGFNTAMVLKHGQSSVMPDSVQGLWAPPLMHITQGFFPYSQLVNRAVQQCYNDLCDVITELADSTQPQQSSSANGKPDPAAMQKRIRILEFAQTKRTEFIKLLVLSQWSRQAVDVSKLIDLQNFIRTRHFAYQTAVQRVADMKRDLVRAQVANPDLQTALEVLTMGRVSNMPEFGYKPPKPLSSKRLLATLQKINRIISTRLVTSDTIPSSLNDYRVHDGRATFSVQGEFELDLSIAEEDVTSQFYFIDIRFLFTPSSPIPKGRFFNELDSQINSILKTKGLSGCFDFIHNLVLVNKINILFKQAISLSRGQWIGALRVELLHRILVVHYWPDKSGPKSWLEIGAHSGRQQRQKVSYLGLRWVRDGKECESAQIHFDTETLSMESILRSVIAIHSAHILRAVYERLCTENLFANHRLSISMQMSKTEPGNCRLNVQLTETRYLNASLEPVSGTMCIHTIPSLLCRLDKGSASDDDFVNRISRLRCIAAMEEIESDAKIFGWESVDHRKFKVDIRRVFPSNILRASFFRNRVWGSSWIIAATTSLSGDDWWILRLKARPLSYPDGSGHARVVAGGFSVQSTRVSSGDQILSPRESRYHFPDLDYSLTGALVMYSNALWLSELGYQDVLPPMDQLQLGSRLEVPCLYLKFDIAKLPRQLRITPLEGAQSKSYVRETFTISYHGIDFRTKNAIVVAHGRFHTPLRKMGLKRLKLDDCVLLRRGGTAFAMRFLVAPGQPIMTDLFERIQRLNIALSLFHTLQQSKITVKSVSLSNLSFVYAPREGFEANIVVRLDRLGHAPDLDPAIVRLRDESLFRLRLDISFNNLSPHNRIKQSLGMILNRSGPGNGVQCVLQLLKLTLPVLRALDRLVTEPQHNSALRVQVSIRGAQTFQIHYFGLRFRFLVNALQRRDKIIWTLKDISSSEGQRDVEQAVEAKLQEKIYRGKGDGWQGLGNGAVAEVDQVGNLLSELDSCFADLTPPAALPAAPSEIAEKKPGKAAKDKGQRTNGTSKINRQSQEVPKESDVIMID
Length1087
PositionTail
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.08
Grand average of hydropathy-0.269
Instability index42.78
Isoelectric point9.36
Molecular weight122158.41
Publications
PubMed=28649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     283.68|      82|     261|     243|     345|       1
---------------------------------------------------------------------------
  243-  327 (121.87/90.07)	LSSKRLLAT.L..QKINRIISTRLVTS.....DTIPSSLNDY..RVHDGRATFSVQgEFELDLSI.AEEDVTSQFYFIDIRFLFtPSSpIPKGRFF
  369-  410 (43.14/35.40)	LSRGQWIGA.LrvELLHRILVVHYWPD.....KSGPKSWLEI..GAHSGR..............................................
  498-  588 (118.68/72.68)	LTETRYLNAsL..EPVSGTMCIHTIPSllcrlDKGSASDDDFvnRISRLRCIAAME.EIESDAKIfGWESVDHRKFKVDIRRVF.PSN.ILRASFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.23|      32|      36|     591|     624|       2
---------------------------------------------------------------------------
  591-  624 (52.48/38.16)	RVWGSSWIIAATTSLSGDDwwILRLKARPLSYPD
  630-  661 (56.75/32.54)	RVVAGGFSVQSTRVSSGDQ..ILSPRESRYHFPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.62|      38|     149|      49|      89|       3
---------------------------------------------------------------------------
   49-   89 (64.89/60.35)	QQVNGFKGDDGKGQ....GFNTAM.VLKHGQSSVMPDSvqGlWAPP
  198-  240 (59.73/43.60)	QRVADMKRDLVRAQvanpDLQTALeVLTMGRVSNMPEF..G.YKPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.59|      12|     104|     762|     773|       4
---------------------------------------------------------------------------
  762-  773 (21.29/12.83)	LRKMGLKRLKLD
  867-  878 (21.29/12.83)	LRDESLFRLRLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.01|      24|     149|     881|     904|       5
---------------------------------------------------------------------------
  830-  857 (34.69/25.23)	LSNLSfvyaPREGFEANIVVRLDRLGHA
  881-  904 (43.32/33.68)	FNNLS....PHNRIKQSLGMILNRSGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.13|      39|     217|     694|     740|      10
---------------------------------------------------------------------------
  694-  740 (58.20/51.52)	LQLgSRLEVPCLYLKFDIAKLPRQ...LRI.TPLEGAQsksyvreTFTISY
  911-  953 (57.93/33.38)	LQL.LKLTLPVLRALDRLVTEPQHnsaLRVqVSIRGAQ.......TFQIHY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21557 with Med14 domain of Kingdom Fungi
Unable to open file!