<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21549

Description Uncharacterized protein
SequenceMPDTRDPPLSHEIPALERWKRDVIEPTKRSEQMSWMVLSSALALAHEVGIFDKKPALSGKSGAFFDAVKPDAKAYTEHLKIRRERLPKLLYCFINLMSSRLGCTSFMCPESTVALLEVDKDLSTDLNQQWQSFMNCWVELTKLTKSITDTLFPLMTADDDEKFQNCLQEKQQLLSHWYTTVDFGNCHYEDLLFIEYQYLRVLTSSTGMQRVITHYSQPQSAHNFRPTFSARPFQSDHEYHLVEEVIDGCCHIIELTIRKAESNTNNSLHYAPIRMFSRMISASIFLLKALALGVRRTKLAESLQVLEMAISALQTSNLDDIHLAAQYGELLKIQVDRLRRSFESSGTPHYHGKESAKHSGEGHCSIGREQWQPKLQLPANQAASPSSYFPPRLSGGEDLLDDQRYYSSHGQWTETASLDKLDANNQGAVDINTTPAKPNGLSLIVILPPGLSRERNSALPIPSFAHRPSQSLISPSLCLKQTEPGEFDQSDTAHYYSRDKAHVRFIPAGRQRLPIFVFVGAQNYASNFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSVTTSFPTPASSVSGHPRNTTPADESELADKSWGQGPQNSHATGNTDLGSAENLGHRRTDHDRHRLPEGFDMEGRPSATDVDMMDIDSKADTSSFRDSSLDALQQDIGTAFHLCKSVPTITGPDPSFDLISLYGLGPIGRSVMRADPTTGEKINRLRKSYEGKLKGLGLSGRNKAVKNENQAGGLRHLMMWPEEEWQIQKVHGKEIKVAEAESGLQKLQMRAMKLEAGPLPNSEYWEDILGHEKSSKHAVIESGKRAVSTPNALRPTLQANGAPAAAAAPERARPTRGKKRHYDDNSFVGYGEGFVDDEDEGALYSNSEDRSGKKKRKKVFQPSHKSHQTDKLMDSFQEHISKMSPSMPERTGSYGVGMYGIGAR
Length940
PositionHead
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.626
Instability index50.79
Isoelectric point6.70
Molecular weight104558.12
Publications
PubMed=28649280

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21549
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.64|      36|      37|     580|     616|       1
---------------------------------------------------------------------------
  543-  577 (49.74/18.88)	GQPLSSPPSS.TPMSTQN.SQQPTVSVTTSfPTPASS
  580-  615 (63.33/26.51)	GHPRNTTPADESELADKSWGQGPQNSHATG.NTDLGS
  620-  653 (56.57/23.11)	GHRR..TDHDRHRLPEGFDMEGRPSATDVD.MMDIDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.21|      45|     272|      69|     145|       2
---------------------------------------------------------------------------
   95-  145 (72.41/ 8.10)	NLMSSRLGCTSFMCPEStvalLEVDKDLSTDlnQQWQSFMNCWVELTKLTK
  376-  420 (80.80/49.37)	QLPANQAASPSSYFPPR....LSGGEDLLDD..QRYYSSHGQWTETASLDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.63|      37|     234|     662|     701|       3
---------------------------------------------------------------------------
  662-  701 (52.87/43.94)	DSSLDALQQdIGTAfHLCKSVPTITGPD.....PSFDlISLYGLG
  703-  733 (30.82/14.34)	..........IGRS..VMRADPT.TGEKinrlrKSYE.GKLKGLG
  906-  938 (58.94/34.66)	DKLMDSFQE......HISKMSPSMPERT.....GSYG.VGMYGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.70|      21|     279|      69|      89|       4
---------------------------------------------------------------------------
   69-   89 (38.98/24.78)	KPDAKAYTE.HLKIRRER.LPKL
  353-  375 (29.72/17.19)	KESAKHSGEgHCSIGREQwQPKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.77|      19|     279|     214|     232|       5
---------------------------------------------------------------------------
  214-  232 (37.98/22.76)	HYSQPQSAH.........NFRPTFSAR.P
  486-  514 (23.79/11.46)	EFDQSDTAHyysrdkahvRFIPAGRQRlP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.85|      23|      37|     757|     779|       6
---------------------------------------------------------------------------
  757-  779 (40.23/28.84)	PEEE.WQIQKVHGKEIKVAEAESG
  796-  819 (36.62/25.56)	PNSEyWEDILGHEKSSKHAVIESG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21549 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDEGALYSNSEDRSGKKKRKKVFQPSHKSHQTDKLMDSFQEHISKMSPSMPERTGSYGVGM
2) NFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSVTTSFPTPASSVSGHPRNTTPADESELADKSWGQGPQNSHATGNTDLGSAENLGHRRTDHDRHRLPEGFDMEGRPSATDVDMMDIDSKADTSSFRDSSLD
3) SKHAVIESGKRAVSTPNALRPTLQANGAPAAAAAPERARPTRGKKRHYDD
874
527
811
934
666
860










Molecular Recognition Features






MoRF SequenceStartStop




1) KKVFQP
2) MYGIGAR
893
934
898
940