<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21548

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEEGLDVDDLFGDPNTLDLGLSAAQPTKGLAQRLDEMRLLGCCRKIAWSRLGCIAYISQDGLQVIVRHLACNPIDGKWALTEEYSQSQIPQLHLGQQLLHLCWNETGSDLAVLDASGRISILSISAALNSLGISRQTVVDPPDDGSQVVGMMWMNSNRAVHAFHQAAKLNGRWNYSPYRRKPIGPFHPAGKPALICFTRNGIMRLLYQNPDQRWAEVSAELKTTNQSDRILTHAACLPSPKKLSLYRVQIMWNPSNWDQTQQRQASGVMPFPVPSIRISHCKTELPGRVFSFNKDQSDDLQNLAPNQSFLYQLTNLDLVSGQFDNTGATTSPPWILAVYSSPFNSAGHDPQQQEPPASVLVRWQLETSTLNLHPVFEESLSKKTNGQQRTKLEIRRMEDIHFDKHVVSIDQIEFGCVLAITHDDSSVSFFDPKSMSQFAEGGDNNTVTSLAQAGFRFPSDTPGLNICFSPNSCLAVVLDADWQAQLRIAGYNFEPDGDLHEGKNSNGIIALALTFSRGCAIEYNTDDLIMTISRHLSTDAQNVFVNEVYRALPINCNFSMEQDKPMQHPYVPRCLSLQAALGFQNFQTPRGLPYSVPWAILHLRHASLLFAFFFQYSKQPKENESLDHDVLQMVYGNTKWALDFTQYLLDDLFALAREFEPVLDDQEALAQKGEGLRGVHTSSMASPFAGDGRGYSKELYTLIDSAPFRFNVYEKFLSSVESAIKNAYQRAGFGDDERRTPEKDLLLNSRIPAVMIPVLVSLFKQIIPAIQTEIDQMSIYLTDYSWLGFCSDRRTEHFRQTRAVDVVKKVPLRGFNLSNNNIEPNMSSEITSNGKKAGSSSRRRCVRCCETTGDPSSPRSILYFQLTLRLQLIRSCLCGGMWTFENGPPTTAATHKQVG
Length903
PositionTail
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.09
Grand average of hydropathy-0.305
Instability index45.90
Isoelectric point6.08
Molecular weight101128.51
Publications
PubMed=28649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21548
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     437.92|      92|      92|     181|     272|       1
---------------------------------------------------------------------------
   27-   84 (61.42/32.49)	............AAQ.PT.K.GLAQRLDEMRLLGCC..RKIAWSRLGC.IA.YISQDglQVI..VRHLACNPI...........DGKWAL..........................
   87-  176 (92.63/52.86)	EYSQSQIPQLH.LGQ.QL.LhLC...................WNETGSDLA.VLDAS..GRIsiLSISAALNSlgisrqtvvdpPDDGSQV.VGMMWMNSNRAVHAFHQAAklnGR
  181-  272 (166.23/100.89)	PYRRKPIGPFHPAGK.PA.L.ICFTRNGIMRLLYQN..PDQRWAEVSAELK.TTNQS..DRI..LTHAACLPS...........PKKLSLYRVQIMWNPSNWDQTQQRQAS...GV
  274-  363 (117.64/69.18)	PFPVPSIRISHCKTElPGrV.FSFNKDQSDDL..QNlaPNQSFLYQLTNLDlVSGQF..DN....TGATTSP............PWILAVYSSP..FNSAGHDPQQQEPPA...SV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.26|      77|     100|     403|     490|       2
---------------------------------------------------------------------------
  403-  490 (112.16/113.86)	DIHFDKH...VVSIdQIEF..GCVLAITHDDSSVSFfdPKSMSQFAEGGDNNTV.TSL.AQAGFRFPSDTPgLNICFSPnSCLAVvldadwQAQL
  502-  585 (117.10/81.42)	DLHEGKNsngIIAL.ALTFsrGCAIEYNTDDLIMTI..SRHLSTDAQNVFVNEVyRALpINCNFSMEQDKP.MQHPYVP.RCLSL......QAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.80|      28|      40|     602|     630|       3
---------------------------------------------------------------------------
  602-  630 (46.04/31.58)	WAiLHLRHASL..LFAFFFQYSKQPKENESL
  644-  673 (40.76/23.18)	WA.LDFTQYLLddLFALAREFEPVLDDQEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.11|      11|      17|     691|     707|       5
---------------------------------------------------------------------------
  691-  703 (16.37/19.22)	PFAGDgrGYSKEL
  711-  721 (21.73/ 6.23)	PFRFN..VYEKFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21548 with Med16 domain of Kingdom Fungi
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