<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21542

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLMTDTRIVQDLIAPLSSSSLSLNTKDIQNIFAITAEWILDVARWHASNIVDEHQMGGLMSSPDALALFESLGILLVALSATTKAHDALTSESTSDFKITLGQALTAYLSTSATISLNLRNRLDSLQKGYQLYGEPPSKDLDVQMMDGMNMNALQFEASVLDGPVINSRAGLYVYINALLIGRPLFDDEMLLSYLSNRYGGQQEVLIQELITATFDVLSNAMYRNESTRNMFIFRSFLVNKLPLFIAGMVATSMEQIPMEMCISHALNRVDPNAFPSFSQMFEMSGNTVLSDVRQEFLFACALHRLIPEASIERLLGENPMQTLPVGGRYVKDNIVAQILSNQGAADRLISEIEMMEGNAGAVVAAVTDVIHSLCEQKETVTLKSICDSLSRRPQVLDAMLLFRSPKSILQPLCTLLDSWKWDEDQGESQPVYDEFGSILLLVMAFKYRYDLSQYDLGVTASSSFVLKLFERGSTSMKLTGLDAKQNKSVGDWISALFMSEGISEETCQTLGACEMGMLELDTMKGGFEYLLQPFLLPSLVFALKWLGNYIWESSEADLLLLLKVLHALVKPSSISGEAEACHRTVLNIAARGLEEQLKDVRTRLPGGRSDNQSDIQPSPHQDIQQEIQAILDILDPYLSFQCNGNSRRSELDSWTTHADGICGAIRVTFQGLVLWSASAEMSMSPHAYTHRLILAGIRLSTASNVLSVLLDELKAQAEEASGSLDLAIDIAATLICAPIPESFAQEQTIYHPLDTTKEAFPRCLLLTLRQALMIQHQNVPKLSEKDPTRAEVIVRLTRRVNALLTPPAHVGALDVSNIIDDMNLEAAAAAAAAGHDVMDLSNGNGTPNDQGAAPGESIDQILNNAVAATANDHHGAGNEAHDLDTTGMDTSLDDILNAAHMGNPEFLDLDMDGMF
Length916
PositionTail
OrganismTalaromyces amestolkiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.06
Grand average of hydropathy0.019
Instability index41.10
Isoelectric point4.63
Molecular weight100324.32
Publications
PubMed=28649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21542
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.19|      21|      31|     844|     866|       4
---------------------------------------------------------------------------
  844-  866 (34.36/33.28)	GngTPNDQGAAPGE...........SIDQILNNA
  869-  900 (28.84/19.13)	A..TANDHHGAGNEahdldttgmdtSLDDILNAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.27|      75|     234|     494|     577|       6
---------------------------------------------------------------------------
  494-  577 (112.94/94.00)	ISALFMSEGISEETCQtlgacEMGMLE.LDTMKGGFEYLLqpfLLpSLVFALKWLGNYIWESSEAD......LLLLLKVLHALVKPSSISG
  731-  812 (119.33/74.34)	IAATLICAPIPESFAQ.....EQTIYHpLDTTKEAFPRCL...LL.TLRQALMIQHQNVPKLSEKDptraevIVRLTRRVNALLTPPAHVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.77|      23|      33|     252|     274|       8
---------------------------------------------------------------------------
  252-  274 (42.04/32.83)	TSMEQIPMEMCISHALNRVDPNA
  288-  310 (37.73/28.60)	TVLSDVRQEFLFACALHRLIPEA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21542 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HDVMDLSNGNGTPNDQGAAPGESIDQILNNAVAATANDHHGAGNEAHDLDTTGMD
836
890










Molecular Recognition Features






MoRF SequenceStartStop




NANANA