<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21532

Description Mediator of RNA polymerase II transcription subunit 14
SequenceGGEGKGGETADIRAGPALTPTSGGARPPLPLFPPARRPHPTPTRPPASGRPTAGRKGTGCCRKSPFGSLSVLPNNFRFGPSTWTLRLPGGAASDRLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPSKPTQLSYKYYFMSVNAADREDSPVMALLLQQFKEDIQELVYRTKNGKQPRSSTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSINEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1477
PositionTail
OrganismLipotes vexillifer (Yangtze river dolphin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Lipotidae> Lipotes.
Aromaticity0.07
Grand average of hydropathy-0.247
Instability index51.76
Isoelectric point9.23
Molecular weight163464.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21532
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     227.60|      32|      32|    1124|    1155|       1
---------------------------------------------------------------------------
   33-   60 (40.51/12.17)	PPAR..R............................PHPTP.TRPPASGrPTAGR.KGT.G.C
   61-   89 (36.91/10.47)	CRKS..P.......................F..GSLSVLP.NNFR.FG.PSTWTlRLP.G..
 1025- 1062 (36.92/10.48)	PPPQqqP.....................FPKqpGSSGAYPlTSPPTSY.HSTVN.QSP.SmM
 1124- 1150 (48.82/16.10)	............................SPS..GRAGNWP.GSPQVSG.PSPAT.RMP.G.M
 1151- 1181 (36.16/10.12)	SPAN..P..................slhSPV..PDASH....SPR.AG.TSSQT..MPtN.M
 1182- 1235 (28.28/ 6.39)	PPPRklPqrswaasiptilthsalnillLPS..PTPGLVP.GLAGSYL.CSPLE.RFL.G..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.98|      14|      19|    1076|    1094|       2
---------------------------------------------------------------------------
 1076- 1089 (25.41/19.58)	PSGALRAPSPASFV
 1110- 1123 (25.57/ 6.59)	PHGTLDPSSPYTMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.74|      19|      19|     689|     707|       3
---------------------------------------------------------------------------
  689-  707 (34.00/17.23)	IPH.QGVQMEGDG......FSHAIRL
  710-  735 (21.80/ 8.58)	IPPcKGVNEETQKaldrslLDCTFRL
  752-  770 (32.94/16.48)	CPL.NGTSTREQG......PSRHVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.75|      18|      19|    1298|    1316|       5
---------------------------------------------------------------------------
 1258- 1278 (18.35/ 7.96)	.NEPGVI..MFKTdalkcRVALSP
 1298- 1316 (29.30/22.46)	PDELQVLeKFFET.....RVAGPP
 1319- 1332 (22.09/11.16)	ANTLI...AF..T.....KLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     269|     298|       6
---------------------------------------------------------------------------
  269-  298 (48.89/30.15)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  299-  332 (45.75/27.75)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1386|    1409|       8
---------------------------------------------------------------------------
 1385- 1408 (39.65/19.85)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1409- 1434 (34.41/16.19)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.18|      13|      19|     924|     942|      10
---------------------------------------------------------------------------
  924-  937 (20.93/10.67)	YqCFSILPQSSTHI
  945-  957 (25.24/18.35)	Y.CIDIYCRSRGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.93|      34|     393|     470|     503|      11
---------------------------------------------------------------------------
  470-  503 (62.40/43.85)	GNSEC....LHIFVDLHS...GMFQLMLYGLD.QATLDDMEK
  866-  907 (46.52/30.72)	GCSNChntiLHQLQEMFNktpNVVQLLQVLFDtQAPLNAINK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|      19|     385|     397|      13
---------------------------------------------------------------------------
  385-  397 (23.09/17.37)	DENDVSKPLQIFH
  405-  417 (21.79/15.92)	DSKLVERAMKIDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      19|      32|     102|     120|      14
---------------------------------------------------------------------------
  102-  120 (31.17/22.92)	VERKIEIVQFASRTRQLFV
  135-  153 (32.43/24.16)	VEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.93|      20|      20|     823|     842|      15
---------------------------------------------------------------------------
  360-  374 (20.40/ 9.84)	LSV.WN..QQVLGRKTGT.....
  823-  842 (34.26/21.72)	VRV.YN..YRKLILCYGTTKGSS
  843-  865 (27.28/15.74)	ISIqWNsiHQKFHISLGTVGPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.21|      14|      28|     191|     204|      22
---------------------------------------------------------------------------
  191-  204 (26.56/13.55)	RLPTCIRDKII....PPD
  217-  234 (19.65/ 8.14)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21532 with Med14 domain of Kingdom Metazoa
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