<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21528
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MKTLLDIHRLLPCEDWDVACVDCSFYSEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPSMQQPQPPPSQALPQQLSQLHHPQHHQPPPQAQQSPIAQNQPPQIPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA |
Length | 639 |
Position | Tail |
Organism | Mus musculus (Mouse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae>
Murinae> Mus> Mus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.765 |
Instability index | 93.44 |
Isoelectric point | 8.93 |
Molecular weight | 71917.79 |
Publications | PubMed=19468303
PubMed=21183079
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21528
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 170.02| 25| 25| 89| 113| 1
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84- 109 (45.38/ 9.42) AQLQlQQVALQQQQQQQQQQQFQQQQ
110- 132 (41.29/ 7.75) AALQqQQ...QQQQQQQQQQQFQAQQ
174- 198 (40.62/ 7.47) LQRM.AQLQLQQQQQQQQQQALQAQP
215- 239 (42.73/ 8.34) ALPQ.QLSQLHHPQHHQPPPQAQQSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.70| 20| 22| 465| 484| 5
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465- 484 (35.20/20.30) QQDLCQPLLDAVLA....NIRSPV
486- 509 (31.50/17.43) NHSLYRTFVPAMMAihgpPIVSPV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.52| 16| 45| 199| 214| 6
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199- 214 (35.01/11.01) PMQQPSMQQPQPPPSQ
245- 260 (31.51/ 9.06) PPQIPPQSQSQPLVSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.08| 18| 22| 533| 550| 7
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533- 550 (32.84/18.74) VARLDPKFLVNLDPSHCS
558- 575 (32.24/18.27) ICKLDDKDLPSVPPLELS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 93.86| 31| 33| 382| 414| 8
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382- 414 (44.45/34.88) QYLDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
419- 450 (49.41/29.67) SLLDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.79| 11| 26| 597| 607| 12
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597- 607 (23.12/11.53) NPFLQSVHR.CM
625- 636 (18.67/ 8.10) NTWAQSIHQaCL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.35| 11| 97| 354| 366| 14
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354- 366 (19.81/12.29) VPSPGPlnTPVNP
452- 462 (25.55/10.48) VPTPPP..PPVLP
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