Description | Mediator of RNA polymerase II transcription subunit 15 (Fragment) |
Sequence | XDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIPQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPSMQQPQPPPSQALPQQLSQLHHPQHHQPP |
Length | 218 |
Position | Tail |
Organism | Mus musculus (Mouse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.318 |
Instability index | 98.53 |
Isoelectric point | 9.77 |
Molecular weight | 25609.16 |
Publications | PubMed=19468303 PubMed=21183079 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21525 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 160.07| 47| 63| 71| 132| 1 --------------------------------------------------------------------------- 71- 123 (79.37/15.15) QlqLQQvalQQQQQ.......QQQQQQFQQQ..QAALQQQQQQQQQQQQQQQFQAqQNAMQQ 133- 188 (80.69/15.57) Q..LQQ...QQQQQhliklhhQSQQQQIQQQqlQRMAQLQLQQQQQQQQQQALQA.QPPMQQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) SRTFRRYLGNEIDLEP 2) WRLWRYGL | 29 123 | 44 130 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab