<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21524

Description Mediator complex subunit 12
SequenceMGNPVPARARRGGRLPPQGVAPRGTLSGSRTFRRYLGNEIDLEPRGPKCSAAAELRPTPGWAPPPLQSVLSDGSRRPSVPLGSFRQRSRVSNVPPVVSRLPSSQPPPPFSVPSPPPPSAGPGWRLWRYGLGKMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPTPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLSTRPPYPGVMPTAMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHAGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQAAAAQQQQQQPQQQQQQQQQQYHIRQQQQQQILRVRPWDGSWALRASGGEEAASASRSSSSRSFLLAEWLWQAAGA
Length2224
PositionKinase
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.07
Grand average of hydropathy-0.445
Instability index56.74
Isoelectric point7.38
Molecular weight246677.40
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21524
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.12|      20|      20|    2139|    2158|       1
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 2118- 2136 (30.25/14.36)	QGVQAGVRS.ASIL.PEQQQQ
 2145- 2165 (34.50/17.54)	QQQQAAAAQQQQQQpQQQQQQ
 2166- 2179 (22.37/ 8.48)	QQQQYHIRQQQQQQ.......
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     349.35|      56|      57|    1921|    1976|       2
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 1817- 1867 (55.66/20.52)	YL....EPLPLP..........P.EdEEPPAPTLLEPEKKAPEPPktdKPGAA.PPSTE......E..R.KKKSTK.
 1869- 1920 (43.68/14.46)	......KKRSQPAAktedygmGPgR.SGPY.GVTVPPDLLHHANP..............GsISHLS..Y.RQGSIGL
 1921- 1976 (101.23/43.61)	YT....QNQPLPAG.......GP.R.VDPYRPVRLPMQKLSTRPP...YPGVM.PTAMTG.VMGLE..P.SSYKTSV
 1977- 2022 (60.82/23.14)	YR....QQQPAVPQ.......GQ.R.LR.........QQLQAKIQ...SQGML...GQSS.VHQMT..PsSSYGLQT
 2030- 2080 (57.71/21.56)	VShvglQQHAGPA........GT.M.VPPSYSSQ.PYQ..ST......HPSTN.PTLVDP.TRHLQqrP.SGY....
 2082- 2114 (30.25/ 7.65)	......HQQA.PTY.......GH.G.LTSTQ..RFSHQTLQ.QTP...MIGTMtP......................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.27|      29|      37|     270|     299|       3
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  270-  299 (48.22/35.81)	KKEEVFGYLAKYTVPVMRAAW..LIKMTcAYY
  308-  338 (51.04/32.12)	KKRHVIDPFMEWTQIITKYLWeqLQKMA.EYY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     599.52|     178|     231|     349|     579|       4
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   98-  161 (65.53/18.80)	.......................................................................................................................S.RLPSS...Q...............PPPPfSVPSPPPPS....AGPGWRLWRYGLGKMAAFGILS.....YEH..RPL...KR..PRLGPP.DVYPQDP..........
  349-  544 (298.21/244.28)	GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPTPQ...............PPTS.STPSTPFSD..LLMCPQHRPLVFGLSCILQTILLCcpsalVWH..YSLT.DSR..IKTGSPlDHLPIAPSNLPMPEGNS
  583-  777 (235.78/120.97)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQdvllqfldtqapmltDPRS.ESERVEFFNlvLLFCELIRHDVFS..................HnmYTCTlISRgdLAFGAP...GPRPPSPFDDPADDS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     326.87|      84|     229|    1454|    1542|       5
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 1454- 1542 (125.37/86.34)	MQLIcyphRLLDNEDGENPQRQRI.....KRILQNLDQWTMRQ...SSLELQLMIK..QTPNNEMNSLLENIAKATiEVFQQSAETGSSSGNTASNM.PS
 1561- 1635 (81.64/44.19)	LSLV......LTCLKGQDEQREGLltslySQVHQIVNNWRDDQyldDCKPKQLMHEalKLRLNLVGGMFDTVQRST....QQTTE...............
 1693- 1776 (119.85/68.50)	MNLV....KKLRKELGER.QSDSL.....EKVRQLLPLPKQTRdviTCEPQGSLID...TKGNKIAG.FDSIFKK..EGLQVSTKQKISPWDLFEGLkPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.31|      17|      56|    1234|    1250|       6
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 1177- 1190 (20.02/ 9.07)	..SENPANRYS...FVCNA
 1195- 1212 (25.77/14.02)	CVGHHDPDRVNDiaILC.A
 1234- 1250 (32.52/19.82)	CSSNNGTCGFND..LLCNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      27|    1640|    1653|       7
---------------------------------------------------------------------------
 1640- 1653 (24.50/15.87)	LLEIIISGTV..DMQS
 1664- 1679 (20.20/11.76)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.58|      25|      27|    1286|    1312|       8
---------------------------------------------------------------------------
 1286- 1312 (39.46/22.42)	PSLLNAACSEQDSEPGARLTCRIllHL
 1316- 1340 (47.11/22.30)	PQLNPCQSDGNKPTVGIRSSCDR..HL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.49|      12|      58|      12|      26|       9
---------------------------------------------------------------------------
   12-   26 (18.64/16.02)	GGRLPPqgvAPRGTL
   73-   84 (21.85/ 9.55)	GSRRPS...VPLGSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.70|      31|      43|    1058|    1089|      11
---------------------------------------------------------------------------
 1058- 1089 (51.59/43.70)	CIVAVLRH.YHACLILnQDQMAQVFEGLCGVVK
 1103- 1134 (51.12/37.74)	CILAYLYDlYTSCSHL.KSKFGELFSDFCSKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.82|      16|      18|    1363|    1378|      12
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 1363- 1378 (28.25/15.10)	LGDAE.LKGSGFTVTGG
 1382- 1398 (24.57/12.13)	LPEEEgGGGSGGRRQGG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.14|      19|      21|     778|     796|      13
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  793-  811 (30.86/15.26)	PGLS...ESMDIDPSSSVLFED
  815-  836 (29.28/14.05)	PDFSlfsPTMPCEGKGSPSPEK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21524 with Med12 domain of Kingdom Metazoa
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