<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21521

Description Mediator complex subunit 23
SequenceMETQLQSIFEDVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRPHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCGMNAREENPWIPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSESEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAINSGSPAPQSNQVDTLTW
Length1365
PositionTail
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.10
Grand average of hydropathy-0.014
Instability index44.92
Isoelectric point6.86
Molecular weight156152.70
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21521
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.58|      26|      89|    1065|    1092|       1
---------------------------------------------------------------------------
 1065- 1092 (47.35/34.72)	DSYYCRLIGRLVDTMAgkSPGPFPNCDW
 1158- 1183 (47.24/28.17)	EPYWIVLHDRIVSVIS..SPSLTSESEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     517.48|     185|     524|     144|     428|       2
---------------------------------------------------------------------------
  188-  399 (306.54/333.92)	RKLYPEgKLPHWLLGNLVSDFVDTFRPTARI..NSICGRcsLLPVVNNsgAICNSWKLDPA.....TLRFPLKGLLPY.DKDLFEPQTALLRYVL...EQPY.SRDMVCNMLGLNKQHKQRCPVLED.........................................................................................................................................................qlvdlvvyamerseteekfddgGTSQLLWQHLSSQLIFFV..LFQFASFPHMV...LSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKN...ALADFLPVMK.LF
  925- 1046 (143.11/58.14)	HKKYPE.KLYFEGLAEQVDPPVQIQSPYLPIyfGNVCLR..FLPVFDI..VIHRFLELLPVsksleTLLDHLGGLYKFhDRPVTYLYNTLHYYEMhlrDRPHlKRKLVHAIIGSLKDNRPQGWCLSD...................................................................................................................................................................................................................................................................
 1222- 1305 (67.83/ 7.13)	...............................................................................................................................tylkcgmnareenpwipddsyycrligrlvdtmagkspgpfpncdwrfnefpnpaahalhvtcvelmalavsgedvgnallnvvlksqplvprenitawmnaigliitalpepywivlhdrivsvisspsltsesewvgypfrlfdftachqsysemscsytlalahavwhhssiGQLSLIPKFLTEVLLPIVktEFQLLYVYHLVgpfLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNymdPICDFLYHMKyMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     434.65|     103|     262|     522|     624|       3
---------------------------------------------------------------------------
  522-  624 (168.09/107.75)	PLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLG...IKGFISQLLPTV..FKSHAWGI..LHTL......LEMFSYRMHHIQP.HYRVQLL
  652-  754 (127.95/80.14)	LITA..LGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQ....GTWCKDILQTImsFTPHNWAS...HTLscfpgpLQAF.FKQNNVPQ.ESRF...
  787-  889 (138.60/87.46)	PLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMV..WKYNIVTLdrLILC......LAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      28|     135|     144|       7
---------------------------------------------------------------------------
  135-  144 (15.61/ 8.60)	RDLLKVILEK
  164-  173 (16.44/ 9.40)	REVIAYILER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21521 with Med23 domain of Kingdom Metazoa
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