<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21515

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLESEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVMGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPAASQPGFGAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCVEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPLNPESSDKSWNSYRLPPVDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGAEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDSAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAASPALRSSKMPAVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEVKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAVPPKIEQLPMPPAAIFSRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQVEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDGSLLIPPKYQSPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSSSSSGNPAAGSSASGSSVPPVSASAPAPAPVVNQISTTSSSGFSASVGGQNPGSGAGSADRTQGSAGCGGDPEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2184
PositionMiddle
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.07
Grand average of hydropathy-0.365
Instability index58.41
Isoelectric point5.53
Molecular weight238774.31
Publications
PubMed=17975172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21515
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.11|      26|      26|    1005|    1030|       1
---------------------------------------------------------------------------
  968-  994 (37.36/16.08)	GYNNVPSVgslADPDY.LNTPQM..NTPVT
 1005- 1030 (47.22/22.53)	GAGVLPSP...ATPRFSVPTPRTP.RTPRT
 1033- 1059 (35.54/14.89)	GGGTASGQ...GSVKYDSTDQGSPaSTPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     159.29|      37|      37|    1492|    1528|       2
---------------------------------------------------------------------------
 1492- 1528 (68.39/33.18)	GSLLIPPKYQSPPAAAQGQA..TP.GNAG....PLASNSGSAAP
 1531- 1554 (32.57/11.29)	GSAFNPTSSSSSGNPAAGSS..AS.GS.................
 1556- 1583 (31.27/10.50)	....VPPVSASAPAPA.......PvVNQI....STTSSSGFSA.
 1589- 1619 (27.06/ 7.92)	..........NPGSGA.GSAdrTQ.GSAGcggdPEPGQS.SSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      26|     514|     525|       3
---------------------------------------------------------------------------
  514-  525 (24.80/ 9.22)	NPMDSPHSPISP
  540-  551 (22.89/ 7.96)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.14|      23|      26|    1714|    1739|       4
---------------------------------------------------------------------------
 1714- 1739 (38.99/39.10)	QvfyIQYLKSM..AFSVYCQCR...RPLPTQ
 1741- 1768 (30.15/19.44)	H...IKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.58|      33|      37|      53|      86|       5
---------------------------------------------------------------------------
   53-   86 (56.07/39.68)	DDPILLSFIRC.LQANLLCVWRRDVKPDCKELwIF
   90-  123 (53.51/32.00)	DEPNLVGVIHHeLQVVEEGLWENGLSYECRTL.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1098|    1122|       6
---------------------------------------------------------------------------
 1098- 1122 (51.64/36.91)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1125- 1153 (36.91/23.92)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2042|    2069|       7
---------------------------------------------------------------------------
 2042- 2069 (37.05/25.72)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2072- 2100 (44.88/22.39)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.35|      15|      28|    1823|    1849|       8
---------------------------------------------------------------------------
 1823- 1837 (27.56/36.21)	ELLETC..IVNI.ALPNR
 1852- 1869 (24.78/ 6.12)	KLWEWCigIVQMtSLPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.37|      67|     111|     293|     365|       9
---------------------------------------------------------------------------
  293-  365 (107.97/73.58)	CGM.PLTPPTSPeQAVMGesGGTQSAvSHLGSQDGGMITMHSPKRSGKIP..PKLHNHmvHR..VWKE.CILNRTQSKR
  406-  478 (104.40/54.33)	CAVgPSRPPAAS.QPGFG..AGPSSS.SSLPPPASKHKTTERPEKGDKLQkrPLIPFH..HRpsVADEfCVEQDTPGQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.80|      20|      20|     921|     940|      10
---------------------------------------------------------------------------
  921-  940 (35.88/17.64)	FAPLKMLPSQCLLPLKIPDA
  943-  961 (37.45/18.77)	FRPSWAVPPK.IEQLPMPPA
 1061- 1077 (26.47/10.83)	.RPLNSVEPATMQP..IPEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.36|      14|      20|    1347|    1360|      11
---------------------------------------------------------------------------
 1347- 1360 (27.65/16.78)	SPEPLPI..PTLLVGY
 1368- 1383 (21.71/11.05)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.15|      45|     111|     728|     774|      12
---------------------------------------------------------------------------
  728-  774 (66.87/49.28)	TTPG...HS..TPVPDGKNAMSIfSSATKTDVRQDsAAGRAGSSSLTQV.TDL
  791-  832 (66.06/39.30)	DELG...AA..SPALRSSKMPAV..GAEDRPLGKD...GRAAVPYPPTV.ADL
  838-  881 (52.22/29.15)	TPPSleqHPafSPVMNYKDGI...SSETVT......ALGMMESPMVSMVsTQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.40|      17|      17|     568|     584|      14
---------------------------------------------------------------------------
  557-  573 (23.25/13.77)	GLELQQLSTLDDRTVLV
  574-  590 (29.15/19.61)	GQRLPLMAEVSETALYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.90|      17|      17|    1204|    1220|      15
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 1179- 1195 (25.78/14.01)	FLPQVEGARKS..QEPPIS
 1196- 1212 (25.13/13.43)	LLLLLQNQHTQ..PFASLS
 1213- 1231 (24.99/13.30)	FLDYISSNSRQtlPCVSWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      17|     197|     212|      16
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  197-  210 (24.00/16.53)	YKMSDPATRKLIEE
  215-  228 (23.41/ 8.01)	YPMVLKKKEELKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.14|      30|    1265|     131|     161|      17
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  131-  161 (52.76/37.83)	ESEH.LSCAFTFFlHGESNVCTSVEIAQHQPI
 1397- 1427 (50.38/31.42)	ENEAlLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      29|    1993|    2015|      18
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 1993- 2015 (25.52/30.20)	SPNNDdmfvDLPFPDDmDNDIGI
 2024- 2041 (34.86/20.50)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.93|      20|      20|    1661|    1680|      22
---------------------------------------------------------------------------
 1661- 1680 (37.33/24.89)	YTADEDSTSG...NFWLLSLMRC
 1681- 1703 (31.61/19.77)	YTEMLDNLPEhmrNSFILQIVPC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21515 with Med13 domain of Kingdom Metazoa
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