<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21505

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVMGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKHKLLKRCAVGPSRPPAASQPGFGAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCVEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPLNPESSDKSWNSYRLPPVDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGAEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDSAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAASPALRSSKMPAVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEVKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAVPPKIEQLPMPPAAIFSRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQVEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDGSLLIPPKYQSPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSSSSSGNPAAGSSASGSSVPPVSASAPAPAPVVNQISTTSSSGFSASVGGQNPGSGAGSADRTQGSAGCGGDPEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKVRFGAVQRSVLAHVQSGHPGPHLLPSRPLCGAHSVVQRHHEHTLIGEALVLSGSVPPPCSLSPRNLLHSARAPHALLERPLSTVLHCDYSSAGTCHFCSVHYQSDALTLLSWTWKLP
Length2213
PositionMiddle
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.356
Instability index56.52
Isoelectric point5.84
Molecular weight241877.24
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21505
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.97|      28|      28|     998|    1025|       1
---------------------------------------------------------------------------
  938-  967 (25.56/ 6.66)	......PSWAV......P.PKIEQLPMPPaaifsrDGYNNVPS
  974- 1004 (34.40/11.89)	PdylNTPQMNT......PVTLNSAAPASN......SGAGVLPS
 1005- 1032 (46.66/19.16)	P...ATPRFSV......PTPRTPRTPRTP......RGGGTASG
 1569- 1602 (30.36/ 9.50)	T...SSSGFSAsvggqnPGSGAGSADRTQ......GSAGCGGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.14|      23|      26|    1707|    1732|       2
---------------------------------------------------------------------------
 1707- 1732 (38.99/34.33)	QvfyIQYLKSM..AFSVYCQCR...RPLPTQ
 1734- 1761 (30.15/17.09)	H...IKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.23|      48|     260|     279|     330|       3
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  279-  330 (80.86/57.97)	VYPSAFvlisQNDIPVPQSVAGAGGHITVGQQ..GLGSVKDPS.NCGM.PLTPPTS
  500-  524 (30.21/11.46)	...........................TSKQM..NLNPMDSPH.SPIS.PLPPTLS
  542-  593 (65.16/37.96)	VNPALY....GNGLELQQLSTLDDRTVLVGQRlpLMAEVSETAlYCGIrPLNPESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      27|      28|    2037|    2064|       4
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 2037- 2064 (41.86/31.76)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2066- 2095 (46.00/29.47)	YFV.STAKAENLpqwFWSSCPQAQNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.10|      34|     260|      92|     133|       5
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   99-  132 (62.60/52.49)	HHELQVVEEGLWENG.LSYEC....RTLLF..KAIHNLLER
 2135- 2175 (50.50/21.69)	HHEHTLIGEALVLSGsVPPPCslspRNLLHsaRAPHALLER
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.68|      12|      57|    1489|    1500|       8
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 1489- 1500 (23.58/ 9.72)	IPPKYQSPPAAA
 1549- 1560 (22.10/ 8.60)	VPPVSASAPAPA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.90|      17|      17|    1197|    1213|       9
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 1172- 1188 (25.78/12.55)	FLPQVEGARKS..QEPPIS
 1189- 1205 (25.13/12.02)	LLLLLQNQHTQ..PFASLS
 1206- 1224 (24.99/11.91)	FLDYISSNSRQtlPCVSWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.69|      27|      29|    1821|    1849|      10
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 1821- 1849 (44.42/33.54)	C..IVNI.ALPNRSRRSKVSarKIGLQKLWEW
 1850- 1879 (42.27/25.43)	CigIVQMtSLPWRVVIGRLG..RLGHGELKDW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      29|    1091|    1115|      11
---------------------------------------------------------------------------
 1091- 1115 (51.64/37.24)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1118- 1146 (36.91/24.13)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      17|      17|     713|     729|      12
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  713-  729 (30.67/22.61)	DGFGTKDVTTPGHSTPV
  731-  747 (27.70/19.50)	DGKNAMSIFSSATKTDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.36|      14|      20|    1340|    1353|      13
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 1340- 1353 (27.65/14.69)	SPEPLPI..PTLLVGY
 1361- 1376 (21.71/ 9.68)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.31|      36|      55|     830|     865|      14
---------------------------------------------------------------------------
  760-  807 (33.60/13.70)	....SLTQVTDLAPSLHDLDNIfdnsdddelgaaspalRSSKMPAVGAEDRP
  830-  865 (62.86/32.10)	PTPPSLEQHPAFSPVMNYKDGI................SSETVTALGMMESP
  888-  921 (55.84/27.69)	PKPEEVKDFSYVHKVPTFQPFV................GSSMFAPLKML..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      29|    1986|    2008|      16
---------------------------------------------------------------------------
 1986- 2008 (25.52/22.97)	SPNNDdmfvDLPFPDDmDNDIGI
 2017- 2034 (34.86/15.57)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1230|     156|     189|      18
---------------------------------------------------------------------------
  156-  189 (52.23/43.77)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1389- 1420 (59.04/39.61)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.11|      11|      19|    1515|    1525|      25
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 1515- 1525 (18.56/ 8.41)	NSGSAAPSAGS
 1537- 1547 (18.56/ 8.41)	NPAAGSSASGS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21505 with Med13 domain of Kingdom Metazoa
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