<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21504
| Description |
Mediator of RNA polymerase II transcription subunit 1 |
| Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSLITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGSSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGSSSSKLSSSVYSSQGSTGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHLSGTSSGTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKEKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSLKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN |
| Length | 1583 |
| Position | Middle |
| Organism | Felis catus (Cat) (Felis silvestris catus) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
|
| Aromaticity | 0.04 |
| Grand average of hydropathy | -0.682 |
| Instability index | 53.60 |
| Isoelectric point | 8.88 |
| Molecular weight | 168696.45 |
| Publications | PubMed=17975172
|
Function
| Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
|
| GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
nucleolus GO:0005730 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
| GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl
estrogen receptor binding GO:0030331 IEA:Ensembl
LBD domain binding GO:0050693 IEA:Ensembl
nuclear receptor coactivator activity GO:0030374 IEA:Ensembl
peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl
promoter-specific chromatin binding GO:1990841 IEA:Ensembl
protein-containing complex binding GO:0044877 IEA:Ensembl
retinoic acid receptor binding GO:0042974 IBA:GO_Central
thyroid hormone receptor binding GO:0046966 IBA:GO_Central
transcription coregulator activity GO:0003712 IBA:GO_Central
transcription corepressor activity GO:0003714 IEA:Ensembl
vitamin D receptor binding GO:0042809 IBA:GO_Central
|
| GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl
angiogenesis GO:0001525 IEA:Ensembl
animal organ regeneration GO:0031100 IEA:Ensembl
brain development GO:0007420 IEA:Ensembl
cell morphogenesis GO:0000902 IEA:Ensembl
cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl
cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl
cellular response to thyroid hormone stimulus GO:0097067 IBA:GO_Central
embryonic heart tube development GO:0035050 IEA:Ensembl
embryonic hemopoiesis GO:0035162 IEA:Ensembl
embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl
embryonic placenta development GO:0001892 IEA:Ensembl
enucleate erythrocyte development GO:0048822 IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl
fat cell differentiation GO:0045444 IEA:Ensembl
intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl
keratinocyte differentiation GO:0030216 IEA:Ensembl
lactation GO:0007595 IEA:Ensembl
lens development in camera-type eye GO:0002088 IEA:Ensembl
liver development GO:0001889 IEA:Ensembl
mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl
mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl
megakaryocyte development GO:0035855 IEA:Ensembl
monocyte differentiation GO:0030224 IEA:Ensembl
mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl
negative regulation of apoptotic process GO:0043066 IEA:Ensembl
negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl
negative regulation of neuron differentiation GO:0045665 IEA:Ensembl
negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl
positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl
positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl
positive regulation of gene expression GO:0010628 IEA:Ensembl
positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl
positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
protein import into nucleus GO:0006606 IEA:Ensembl
regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl
retinal pigment epithelium development GO:0003406 IEA:Ensembl
thyroid hormone generation GO:0006590 IEA:Ensembl
thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl
ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl
|
Interaction
Repeat regions
| Repeats |
>MDP21504
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
9| 423.52| 49| 50| 965| 1013| 1
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697- 759 (42.46/10.14) PDKP.....K..HQTeddfqrelfsmdvdsQNPIF...DV...NMTA..D.TLDTPHITPAPSQCS.TPPTTYPQ..PVPHP
956- 1009 (70.84/23.28) PLLTtgdlgK..EKT...............QKRVK...EG...NGSS..NSSLSGPGLDSKPGKRS.RTPSNDGK..SKDKP
1010- 1053 (50.88/14.04) PKRK..............................KadtEG...KSPS..HSSSNRPFTPPTSTGGS.KSPGSSGR..SQTPP
1061- 1110 (47.89/12.66) PKIT.....I..QIP...............KGTVM...VG...KPSS..HSQYTSSGSVSSSGSKShHSHSSSSS..SSSSA
1111- 1155 (47.34/12.40) SNSG.....K..MKS...............SK.......S...EGSS..SSKLSSSVYSSQGSTGS.SQSKNSSQ..SGGKP
1159- 1213 (42.43/10.13) PITK.hglsS..GSS...............STKMK..pQG...KPSSlmNPSLSKPNIS..P.SHS.RPPGGSDKlaSPMKP
1214- 1262 (40.88/ 9.41) VPGT.....PpsSKA...............KSPIS...SG...SGGShlSGTSSGTGMKSSSG.....LGSSGSL..SQKTP
1263- 1296 (36.23/ 7.26) PSSN....................................sctASSS..SFSSSGSSMSSSQNQH........GS..SKGKS
1443- 1492 (44.57/11.12) PKHErgspsH..SKS...............PAYTP...Q....NLDS..ESE.SGSSIAEKSYQNS...PSSDDG..IRPLP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 201.39| 48| 48| 152| 199| 2
---------------------------------------------------------------------------
152- 185 (45.18/21.77) ......................KHL..KGLV.NLYNL..........P..GDNKLKTK.MYLALQSLEQDLS
186- 236 (66.83/35.82) KMAVMYWKATNAGP......ldKIL..HGSV.G.YLT..........PrsGGHLMNLK.YYASPSDLLDDKT
237- 300 (53.06/26.88) TSPIILHE..NNVPrslgmnasVTI..EGTS.AMYKLpiaplimgshP..VDNKWTPS.FSLITSANSVDLP
301- 342 (36.32/16.02) ..ACFFLKFPQPIP...........vsRAFVqKLQNC..........T..GIPLFETQpTYVPLYEL.....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.72| 18| 22| 877| 897| 3
---------------------------------------------------------------------------
877- 895 (31.41/24.52) G.FGEEYFDESSQSgDNDDF
913- 931 (28.31/10.18) GdNGETKFKGNSQA.DTVDF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 168.54| 46| 50| 1310| 1356| 4
---------------------------------------------------------------------------
1310- 1354 (73.95/34.39) .......DKLKHGVVTSGPG...GEDpMDGQMGVSTNSSSHPMSSKHNMSGGEFQ
1355- 1393 (49.28/17.97) GK.reksDKEKSKVSTSGS...............SVDSSKKTSESKNVGSTGVAK
1397- 1440 (45.31/15.91) SKhdggsPSIKAKVTLQKPGessGEG.LRPQMASSKNYGS.PL.....ISG....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 182.25| 40| 41| 785| 824| 5
---------------------------------------------------------------------------
544- 602 (36.98/10.04) SSPgygmttgnNPMS....GTTTPTNTFPGGPITTLFnmsmsikdrhesvgH.................GEDFSKV.sqNP.
620- 666 (50.50/16.38) SSP........TPPH....HTPPPVSSMAGNTKN.................HPmlmnllK......DNpAQDFSTLygsSPL
797- 835 (59.74/20.71) SDD........CPPI....GTPVRDSSSSGHSQSALF..............DP......D...vfqTN.NNE.......NPY
836- 873 (35.04/ 9.13) TDP........ADLIadaaGSPSSDSPTN.H.....F..............FP......DgvdfnpDL.......L...NSQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 110.68| 36| 52| 343| 381| 6
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343- 381 (61.08/50.54) ITQFELsKDPDPIPLNHNM.RF...YAALPGQqhCY...FLNKDAP
393- 435 (49.60/30.03) VSKITF.QHPGRVPLILNLiRHqvaYNTLIGS..CVkrtILKEDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.30| 18| 22| 447| 464| 7
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447- 464 (32.49/21.75) ES.RFSVSFQHPVNDSLVC
471- 489 (27.81/17.43) DStHVSCKLYKGLSDALIC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.52| 12| 20| 1497| 1508| 9
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1497- 1508 (19.60/12.81) EKHKKHKKEKKK
1515- 1526 (19.91/13.14) DRDRDKDRDKKK
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|
