<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21503

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIAAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSTSDGPVPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNNSSIGAPSPGPPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVSASTRPRSPAGENVDEHYPKDHDMKMEIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEAKHQLKKITKDILKILNKKSTTETGVGDEGQKTRKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIATTDAGSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPSYNSRTYPATHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTSSQRLNHQSLQQSPLVGGGIDAVLTPTHPSLPSVPLSQDPMRTRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2138
PositionKinase
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.07
Grand average of hydropathy-0.427
Instability index57.49
Isoelectric point7.98
Molecular weight239305.27
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21503
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     262.76|      36|      66|    1809|    1844|       1
---------------------------------------------------------------------------
 1687- 1742 (32.45/ 9.87)	LSWAWfGtvrvdrkvikyeeqhhlllYHTHP.......MP................KPRSYYLEPLPLPP..EEEEEEPTS
 1809- 1844 (68.34/28.80)	QSTLW.G...................YNLMG.......QP................QQPGFFLQNQSLTP..GGSRLDPTG
 1849- 1871 (29.90/ 8.52)	TNT....................................K................QALSNMLQRRS......GAMMQPPP
 1878- 1910 (39.51/13.59)	QQQLI.Q...................MKLLQ.......QQ................QQQRLLRQAQA.RPfqQG....PPG
 1967- 2009 (31.18/ 9.20)	S.........................YNSRT.......YPathsnpalmerlrqmqQQPSGYVQQQA.SP.....YLQPLT
 2017- 2051 (28.59/ 7.83)	QS.LQ.Q...................SPLVGggidavlTP................THP.......SLPS..VPLSQDPMR
 2060- 2082 (32.79/10.05)	QQRLL.Q...................MQQPP.......QP................QQPP...QPQSQT............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     497.89|     164|     201|     857|    1057|       2
---------------------------------------------------------------------------
  869- 1057 (265.53/240.23)	SSLAGSYTTGLCVCIVAVLrRYHSCL..ILNPDQTAQVFeGLCGVVKHVVNPS....ECSSPE.....R..C.ILAYLYDLYVSCsHLRSKFGDLF...SSACSKvkqtiynnvmpansnlrwdpdFMMDFIENPSARSINYSMLGKI..LSDN..AANRYSFVCNTLMNVcMGHQDAGRINDIANFSSELTACC...................TVLSSEWLG..VLKA...LC
 1060- 1268 (232.36/144.04)	SNHVWGFNDVLCTVDVSDL.SFHDSLatFIAILIARQCF.SLEDVVQHVALPSllaaACGDADaepgaRmtCrLLLHLFRAPQAC.LLPQATGKPFpgiRSSCDR.....................HLLAAAHNSIEVGAVFAVLKAImmLGDAkiGNNNVSSLKNDDFTM.RGLRRDGNADDIWTASQNSKSCGksisietanlreyaryvlrTICQQEWVGehCLKEperLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.08|      19|     203|      21|      45|       3
---------------------------------------------------------------------------
   21-   45 (27.66/35.05)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.43/25.57)	PPDV.EQAMKQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.86|      22|     152|    1931|    1958|       4
---------------------------------------------------------------------------
 1924- 1945 (45.62/21.43)	PQLPQYPGLQQAQTMPQGYTMY
 2093- 2112 (29.89/ 7.38)	PLFPR.QGLQQTQQQQQTAAL.
 2115- 2132 (26.35/ 7.69)	.QLQKQLSSNQPQ...QGVTPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      18|     153|     516|     536|       5
---------------------------------------------------------------------------
  516-  536 (24.03/26.97)	SCKRS....GkhRAMAV..AKLLeKRQ
  665-  688 (23.32/13.07)	SCENAnpslG..RRMSVngEKLL.KRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.64|      30|     203|    1352|    1386|       7
---------------------------------------------------------------------------
 1314- 1351 (45.98/25.77)	ILQNLEQWTLRqswlelqlMIKQC..LKDPGSGSVAEMNN
 1352- 1383 (44.66/41.80)	LLDNIAKATIE........VFQQSadLNNNSSNSGMGLFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      15|     154|    1608|    1622|      10
---------------------------------------------------------------------------
 1608- 1622 (23.29/13.50)	KKELGD.KRSESIDKV
 1629- 1644 (20.83/11.26)	PKQTCDvITCEPMGSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21503 with Med12 domain of Kingdom Metazoa
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