<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21502

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPLQQPPMQQPQPPPSQTLPQQLQPMHHPQHHQPPQPQQPPVAQNQPSQLQAQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length676
PositionTail
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.04
Grand average of hydropathy-0.787
Instability index91.02
Isoelectric point9.32
Molecular weight75801.98
Publications
PubMed=17975172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21502
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.85|      17|      17|     133|     149|       1
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   99-  115 (32.38/ 6.17)	QVALQQQQQQQQQQQQQ
  133-  149 (35.48/ 7.66)	QAVVQQQQQQLQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     182.71|      36|      37|     338|     373|       2
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   75-  124 (40.51/ 6.01)	AS..VSAQLQLQQVA...LQQQQ............QQFQQQqvalqqqqqqqqqqqqqQQQQQFQAQ
  185-  219 (54.13/11.38)	QQALQAQPPLQQPP....MQQPQ...........pPPSQTL.................PQQLQPMHH
  303-  352 (45.06/ 7.81)	ASQIVGSGVQVSQNSLtmLSSPSpgqqvqtpqsmpPPPQPS.................PQPGQPSSQ
  353-  399 (43.02/ 7.00)	PNSNVSSGPAPSPSSF..LPSPS.pqpsqspvtarTPQNFS................vPSPG.PLNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      29|      35|     421|     451|       3
---------------------------------------------------------------------------
  421-  451 (40.72/38.96)	LDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
  458-  487 (46.90/33.77)	LDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.64|      29|      47|     220|     249|       4
---------------------------------------------------------------------------
  220-  249 (57.22/15.09)	PQHHQPPQPQ....QPPVAQNQPsQLQAQSQTQP
  258-  290 (46.43/ 8.96)	PGQMLYAQPQlklvRAPMVVQQP.QVQQVQQVQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.87|      16|      46|     488|     503|       5
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  488-  503 (33.17/13.14)	AVPTPP.PPPVPPTKQQ
  536-  552 (26.70/ 9.16)	AIHGPPiTAPVVCTRKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.01|      12|      19|     153|     167|       6
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  153-  167 (19.09/11.34)	KLHHQNQQQiqqQQQ
  173-  184 (22.93/ 6.68)	QLQLQQQQQ...QQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21502 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQALQAQPPLQQPPMQQPQPPPSQTLPQQLQPMHHPQHHQPPQPQQPPVAQNQPSQLQAQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
185
426










Molecular Recognition Features






MoRF SequenceStartStop




NANANA