<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21494

Description Mediator complex subunit 12
SequenceMGNPVPARARRGGRLPPQGVAPRGTLSGSRTFRRYLGNEIDLEPRGPKCSAAAELRPTPGWAPPPLQSVLSDGSRRPSVPLGSFRQRSRVSNVPPVVSRLPSSQPPPPFSVPSPPPPSAGPGWRLWRYGLGKMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPTPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLSTRPPYPGVMPTAMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHAGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQAAAAQQQQQQPQQQQQQQQQQYHIRQQQQQQILRVRPWDGSWALRASGGEEAASASRSSSSRSFLLAEWLWQAAGA
Length2278
PositionKinase
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.07
Grand average of hydropathy-0.452
Instability index56.54
Isoelectric point7.81
Molecular weight252581.07
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21494
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.12|      20|      20|    2193|    2212|       1
---------------------------------------------------------------------------
 2172- 2190 (30.25/13.82)	QGVQAGVRS.ASIL.PEQQQQ
 2199- 2219 (34.50/16.88)	QQQQAAAAQQQQQQpQQQQQQ
 2220- 2233 (22.37/ 8.15)	QQQQYHIRQQQQQQ.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     349.35|      56|      57|    1975|    2030|       2
---------------------------------------------------------------------------
 1871- 1921 (55.66/19.16)	YL....EPLPLP..........P.EdEEPPAPTLLEPEKKAPEPPktdKPGAA.PPSTE......E..R.KKKSTK.
 1923- 1974 (43.68/13.46)	......KKRSQPAAktedygmGPgR.SGPY.GVTVPPDLLHHANP..............GsISHLS..Y.RQGSIGL
 1975- 2030 (101.23/40.87)	YT....QNQPLPAG.......GP.R.VDPYRPVRLPMQKLSTRPP...YPGVM.PTAMTG.VMGLE..P.SSYKTSV
 2031- 2076 (60.82/21.62)	YR....QQQPAVPQ.......GQ.R.LR.........QQLQAKIQ...SQGML...GQSS.VHQMT..PsSSYGLQT
 2084- 2134 (57.71/20.14)	VShvglQQHAGPA........GT.M.VPPSYSSQ.PYQ..ST......HPSTN.PTLVDP.TRHLQqrP.SGY....
 2136- 2168 (30.25/ 7.06)	......HQQA.PTY.......GH.G.LTSTQ..RFSHQTLQ.QTP...MIGTMtP......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.27|      29|      37|     270|     299|       3
---------------------------------------------------------------------------
  270-  299 (48.22/46.42)	KKEEVFGYLAKYTVPVMRAAW..LIKMTcAYY
  308-  338 (51.04/41.65)	KKRHVIDPFMEWTQIITKYLWeqLQKMA.EYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      16|      20|    1179|    1195|       4
---------------------------------------------------------------------------
 1179- 1194 (29.43/11.99)	NP..ANRYSFVCNALMHV
 1200- 1217 (20.73/ 7.18)	DPdrVNDIAILCAELTGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     205.16|      43|      43|      59|     101|       5
---------------------------------------------------------------------------
   19-   47 (44.39/17.78)	.GVAP...RGTLS..GSRTFRRYLG............................NEID.LEPRGP
   59-  101 (80.94/39.30)	PGWAPPPLQSVLS.DGSRRPSVPLG.................SFRQR..SRVSNVPP.VVSRLP
  104-  161 (51.86/22.18)	...QPPPPFSVPS.PPP..PSAGPGwrlwryglgkmaafgilSYEHRplKRPRLGPPdVYPQDP
  762-  787 (27.97/ 8.11)	PGPRPPSPFDDPAdDSERKEAEGSS.................S.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     437.08|     139|     231|     349|     506|       6
---------------------------------------------------------------------------
  349-  499 (235.43/182.35)	GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPTPQ...............PPTSSTPSTPFSD..LLMCPQHRPLVFG...LSCIL
  583-  751 (201.65/119.89)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQdvllqfldtqapmltDPRSESERVEFFNlvLLFCELIRHDVFShnmYTCTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.14|      24|      60|    1510|    1533|       7
---------------------------------------------------------------------------
 1510- 1533 (40.25/27.77)	SLLEN.........IAK...........ATIEVFQQSAETGSSS
 1551- 1594 (24.90/13.98)	SSLERsgvwlvaplIAKlptsvqghvlkAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.55|      44|      60|    1320|    1369|       9
---------------------------------------------------------------------------
 1320- 1369 (61.80/54.08)	PCQSDGNKPtvGIRSSCDRHLLAASQNriVDgaVFA..VLKAVF...VLGDAELK
 1383- 1431 (68.75/41.23)	PEEEGGGGS..GGRRQGGRNISVETAS..LD..VYAkyVLRSICqqeWVGERCLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.14|      16|      16|     996|    1011|      10
---------------------------------------------------------------------------
  996- 1011 (28.57/20.27)	MSYHLPLVQHVQFIFD
 1013- 1028 (25.57/17.25)	MEYSLSISGLIDFAIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      16|    1461|    1475|      11
---------------------------------------------------------------------------
 1461- 1475 (22.26/15.72)	HRLLDNEDgENPQRQ
 1478- 1491 (25.76/13.50)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      21|      24|    1685|    1707|      15
---------------------------------------------------------------------------
 1685- 1707 (31.02/26.42)	QQTTewAVL.LLEIIISGTV..DMQS
 1710- 1733 (27.14/14.99)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.67|      17|      24|    1596|    1612|      19
---------------------------------------------------------------------------
 1596- 1612 (27.94/16.81)	KERDRQKQKSMSLLSQQ
 1623- 1639 (27.73/16.62)	KGQDEQREGLLTSLYSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21494 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLSTRPPYPGVMPTAMTGVM
2) EPRGPKCSAAAELRPTPGWAPPPLQSVLSDGSRRPSVPLGSFRQRSRVSNVPPVVSRLPSSQPPPPFSVPSPPPPS
3) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
4) GAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSV
5) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
6) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQ
7) MGNPVPARARRGGRLPPQGVAPRGTLSGSRTFRRYLGNEID
8) YVSHVGLQQHAGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQAAAAQQQQQQPQQQQQQQQQQ
1869
43
820
760
147
2021
1
2083
2019
118
859
807
196
2078
41
2223










Molecular Recognition Features






MoRF SequenceStartStop




1) SRTFRRYLGNEIDLEP
2) WRLWRYGL
29
123
44
130