<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21482

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDDASIGGLRHGPGNNFSQDGQPYPRGETARFNGVTNSQDGPPHINGVGKNASHNRAIETPPVNHASRGTKGPPELPRITQGFFPFSKLVNRSVQQCWNDLSDLITELAEIQVNPHEFHSSPIPTTGKSPGNQSPENIRKKLRLLEFSHAKRAEFIKLLVLSQWSRQAADVSKLIDIQNFIRTRHQAYTGALQYVGDMKRDLVQAQVANPDLKTALEVLSKGKVESMSNLGYKPPRRLTARGTLKKLQKINRLIGVRLVVREEIPPPFRTYHVHDGRVTFLVPGEFELDLSIGEEDEASQFFFVDIRFLFFPSPPVPKGRFLNELEITINDVLQNSGLTGCFDILHNLVLTNKVNILFKQAVELARSSWSDVLRVELLHRTLVVQYWTLKPGAKSWLEIGIKSGHRRPNSESSGLPSLGFRWMRDGNEVSCEDIDFDAENLSMESLLRSVIALHVSHILSSAYSSIRHSSLFSTGLLSLRAQLTRTEPGDCLLDVQLTETKYLRVSIEPMSGISILSTTPSASERFDGDRNLEKSSVDDIVSRVARLRCNAAIEEIESKVKMLGFEPLNPRAWKVDVRKMFPSNVLRFAFFSHHLWERNWIVAATSSMDGDSWWVVQLRPTVLAKSPSFLDASGRGQSVLRFAQAVTDGFYPALHKIDDTSLADLGHSLSGILAVHANARYLSDLQAIKFYPPPHKLTIESDLRVPDILVRYDASNLPSVFRIAMPVNAKRKNFFKDTIRLAFHGIDPRKKCAIVVAYGSLANPMGGYGQLISNWDRSLVFQKKGGGFAIRLLAPAGYPVIVSLIESLQRLECVLSILESLQRRKIEVRAFSLSSISFVYGPERDLSASINIDLSSNDSLIELSPTELASSPGSLFRLRLHIQFGHHNPHRRIQESLASSLNQASTEAGLEAVVELLTLTLPLMRALDQLMANPSYSEPLRVQVTVRNARTYQIHYPDEGVMFQLIASSHQSRWVWVLKDVSSQENSRDHKITTCLREKLYTSKGDGWRGLEDGVVADASQVGNLMRELEKCFAACRADPGYKPTDSAASPGTSNIPEVSVSARAKGNTDGTKSEHQDSLATLPNNKSTQSQANTATQKEDIIMID
Length1111
PositionTail
OrganismAspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.272
Instability index49.87
Isoelectric point8.79
Molecular weight123629.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21482
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.96|      12|      24|     373|     385|       1
---------------------------------------------------------------------------
  373-  385 (17.44/15.56)	SWSDVlRVELLHR
  400-  411 (22.52/14.72)	SWLEI.GIKSGHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.02|      28|     172|      54|      97|       3
---------------------------------------------------------------------------
   19-   51 (46.78/19.49)	GNNFSQDgqpypRG.ETARFNGVTNSQDGPPHIN
   54-   82 (48.25/54.10)	GKNASHN.....RAiETPPVNHASRGTKGPPELP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.61|      76|     172|     420|     508|       5
---------------------------------------------------------------------------
  420-  496 (123.57/78.30)	L....PSLGFR........WMRDgNEVSCEDI..DFDAENLSMESLLRSVIALHVSHILSS..AYSSIRHSSLFSTGLLSLRAQLTRTEPGDC
  586-  670 (113.03/66.10)	F....PSNVLRfaffshhlWER..NWIVAATS..SMDGDSWWVVQLRPTVLAKSPSFLDASgrGQSVLRFAQAVTDGFYPALHKIDDTSLADL
  693-  732 (28.00/20.70)	IkfypPPHKLT........IESD...LRVPDIlvRYDASNL..PSVFR..IAMPV......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.58|      79|     808|     162|     248|       6
---------------------------------------------------------------------------
  170-  248 (132.77/108.28)	SRQAADVSKLIDIQNFIRTRHQAYTGALQ...YV..GDMKRDLVQAQVAN.PDLKTALEVLSKGKVESMSNLGYKPPRRLTARGT
  974- 1058 (128.81/87.69)	SHQSRWVWVLKDVSSQENSRDHKITTCLReklYTskGDGWRGLEDGVVADaSQVGNLMRELEKCFAACRADPGYKPTDSAASPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.48|      11|      34|     289|     299|       7
---------------------------------------------------------------------------
  289-  299 (19.46/12.28)	GEF..ELDLSIGE
  324-  336 (15.02/ 7.83)	GRFlnELEITIND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21482 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPTDSAASPGTSNIPEVSVSARAKGNTDGTKSEHQDSLATLPNNKSTQSQANTATQKEDIIMID
2) MPGVVMDDASIGGLRHGPGNNFSQDGQPYPRGETARFNGVTNSQDGPPHINGVGKNASHNRAIETPPVNHASRGTKGPPELPR
1048
1
1111
83










Molecular Recognition Features






MoRF SequenceStartStop




NANANA