Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MLPPRGAGLGAPPGADIGLEVQGPGKFYGPPRKVRIGRRGCEAGMPTRGRQVESNTRGGFELLISAHRACGLARRARLTYLPARLLHTSASCTSRAGCPNAKMADAKDSRERDHTFSSADRIRQLNEIDQDVAKLIHSAGLAIQALTNARAGESPTANSLESHKARFKEATSQYFALLSSIDVRLRRQVYALEEASILAPDTASRAGDLQAAGGSAVGASNPLDVSWLNSRKDTVGKDKEAELWAVAREFVERISNPAAAGSGTKAEGEREKMEVD |
Length | 276 |
Position | Head |
Organism | Aspergillus ellipticus CBS 707.79 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.479 |
Instability index | 40.51 |
Isoelectric point | 9.38 |
Molecular weight | 29472.83 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21480 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.06| 20| 26| 3| 23| 2 --------------------------------------------------------------------------- 3- 23 (32.62/22.51) PPRGAGLGApPGADIGLEVQG 30- 49 (39.44/22.36) PPRKVRIGR.RGCEAGMPTRG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LWAVAREFVERI 2) RKVRIGRR | 243 32 | 254 39 |
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