<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21476

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPNPSAGVQPWGRLLRALNNGSGHHDAAQAMGQPDPQLEKLSMAAPQPLPRQPAVIDLTTAPTDSQEREPPAKKLKLEVPPGSCAADGSPAPGSGSELRSTPGTTGSKPHPLSWRGRPVWSFQALISETTGAVETKEDDGASQGRNPASPPPLPLVPWKYTPQESSGSSGAKTGELPATKEVQTTPYHIVVPSVAPKLKGEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHNTVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKVLLDQCLGKCIPVPRAVWLARCVGANEIRAFKRKGTSGALALGLETKWVRDWTSTVQQFLESVISSCGTPDWKVKMTYAVSLTSRLFFERLLDHDQYLAWFLLSLEAAPLNTVPVWLLMLGIFWSNIMRYRKRGRRLAEVLLEKLCQIKQPGQHTALEPLADRLSRCIRRLVLEHTSSVILPNSWEKYKDLISSCLNLEETPDKTMLQNLAERNARVQLPKTHQKTTQRLPQQHVIHLFDTVRSTHDVSSTSSACLNAVEDTASLVSKLLEWAATPFRYGSRRVYISVRLLRKWKMSGVDVDTHILTFLANGQIANQLNMDNVYHIIAELVRSQTFSVGKYLQWLMAKGVANNSSPGPHEAMSNDVRLLLQLPLARLPEYVRNLRNTLLSRAGIPASQEESNIVTMKASIAQQLPKIFGPQNSDAMLTDLSLSDLTWAVKSEIGLWIRRGVTGHYREPTRKHAHIPMLADSRISALTPNEFYIIRNVLESFGDISILADVLKQATTCGDSIVLASVADTVNYHFDSLCVIGAGTDLFKGLVESYARLKRLGVPGLDLIFSLIELGLRMPSEFNTVALLRQDLSRIEGKSALAAPSPLSDHISMAPGGVDTSFQEKLDQVLFSGGGLDESSLDSVFTSLTRALANNGQGKLSANEICRYLAYLRSFHPKRFDAMLVRWVCGLLKSPSRSAMTRILPPLIGVGCVTIHAFVMLVKKLSQSERVASVMPNVTDLRLDLLELLVPPEPGHTRYADMVTYRFYLAQQEFLDKHPEQCLEIIRDAVPLIDTGRSETASDSSQKDLSNCAVILLRTLLTQKPERMVQSCMQKFIGQHTASTVILQKALDSLLDFDQQDPQAMSEAERVIGINNDFSLPICQLKLQILFNAEAGSQVDNGIVDVMFKAAIADARSNRTHWYGLVSLMSHDAVRQIRERAERGFFSVPILDEPSCDPSVTDKSSTIESARFYLTIIEKLAYSIPDTGAPSVAPALVEKMELLLQRFVSMQPNSTGAVDAGQTAQARSNFERSLAFWFSALLRLIVIHRAAFNTPSLAPRPTGLQEQARLLTSIFCISLARLPDRVIRLYPSANYFPHPVQSENYRPCPGILLQTHALDVAAALIDTFPDEARHHCARFLREKCPPFLQFQNDPRFLYLLGPVMDTSNLNSTLPASLPSPAGGGSTPTPTGNLSGGPANPQQAIASVPSGLPSGLSEGVNCIASHLRLQYRGRVLGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1585
PositionKinase
OrganismAspergillus ellipticus CBS 707.79
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.190
Instability index48.16
Isoelectric point8.91
Molecular weight174774.45
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.45|      23|     869|     483|     527|       2
---------------------------------------------------------------------------
  505-  527 (40.40/54.39)	PNSWEKYKDLISS..CLNLEETPDK
 1374- 1398 (34.05/ 8.49)	PTGLQEQARLLTSifCISLARLPDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.60|      35|     869|      41|      76|       3
---------------------------------------------------------------------------
   41-   75 (61.76/31.90)	KLSMAAPQPLPRQPAVIDLTTAP.TDSQEREPPAKK
   78-  106 (35.83/18.43)	...LEVP...PGSCAA.DGSPAPgSGSELRSTPGTT
  911-  933 (32.01/11.04)	KSALAAPSPLSDH...ISMAPGG.VDT.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.45|      92|      98|     623|     717|       4
---------------------------------------------------------------------------
  623-  717 (147.05/106.57)	DVDTHILTFLAN..GQIANQLNMDNVYHIIAEL.VRSQTFSVGKYLQ.WLMAKGVANNSSPGPHEAmsnDVRLLLQLPLARL.PEYVRNLRNTLLSRAGI
  721-  817 (138.40/92.27)	QEESNIVTMKASiaQQLPKIFGPQNSDAMLTDLsLSDLTWAVKSEIGlWIRRGVTGHYREPTRKHA...HIPMLADSRISALtPNEFYIIRNVLESFGDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.58|      54|     869|     177|     245|       7
---------------------------------------------------------------------------
  148-  175 (35.69/32.52)	........PASPPPL......PLVPWK.YTPQESSGSSGAKTG................
  188-  243 (87.85/55.69)	YHIV...VPSVAPKLKgEKVADFSPWTgNHPEDILNEHTAKQGHYDRTQVSQNESNTAR
 1295- 1345 (76.05/35.97)	YSIPdtgAPSVAPALV.EKMELLL.......QRFVSMQPNSTGAVDAGQTAQARSNFER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.40|      30|     619|     247|     276|       8
---------------------------------------------------------------------------
  247-  276 (51.65/32.22)	YAQLKHRS..GLQMLSSVFAAALEKRQNHNTV
  867-  898 (46.75/28.45)	YARLKRLGvpGLDLIFSLIELGLRMPSEFNTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.32|      24|     316|     936|     959|       9
---------------------------------------------------------------------------
  936-  959 (40.89/25.67)	QEKLDQVLFSGGGLDESSLDSVFT
 1251- 1274 (44.43/28.59)	RERAERGFFSVPILDEPSCDPSVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.76|      21|     146|    1038|    1059|      13
---------------------------------------------------------------------------
 1038- 1059 (30.36/22.41)	LSQSERVASV.....MPnVTDLRLDLL
 1178- 1203 (30.40/17.33)	MSEAERVIGInndfsLP.ICQLKLQIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21476 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLYA
2) MIPNPSAGVQPWGRLLRALNNGSGHHDAAQAMGQPDPQLEKLSMAAPQPLPRQPAVIDLTTAPTDSQEREPPAKKLKLEVPPGSCAADGSPAPGSGSELRSTPGTTGSKPHPLSWRGRPVWS
3) QALISETTGAVETKEDDGASQGRNPASPPPLPLVPWKYTPQESSGSSGAKTGELPATKEVQTTPYHIVVPSV
4) STLPASLPSPAGGGSTPTPTGNLSGGPANPQQAIASV
201
1
124
1484
248
122
195
1520










Molecular Recognition Features






MoRF SequenceStartStop




1) AKKLKL
2) PWGRLLRAL
3) VPWKYT
73
11
157
78
19
162