<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21469

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPGGSITNIRVIDGFSHIYWRIYTEEPNIANNPGEPPANGYTILKHLSRLKDLELQLRDRNCLVSSYPRRLCLWLFSATPGFESLTSLSPNEGKDDQPSRLIIGSATLKVSSSGSVSSSDLVKNLSTEPQNTPGSTGPQRQNALTPYATIYASFISAMSGAVSLQLIRQRTAIPLGSRTLFTAIERDSYENSKIVNTDPISASSLTTLQIQLTSVGKLTVALQTVSQAGLMRLRTPEDESAVIHETPPGTDLWLSPSGSIARLVTTNPSRTNAPSPYPLGGGSLGNEKPGVTNRKQWKVNVLWWLANFGLPVDDIDEDAWVEVEVWEPFYSRLAGEIWRPNDESSSTLPLKRILWPANYCFKRTKSASSDSFGQMESVCPVIGDPLDFAEKWRVTEKPTFTEASPKPPSVHQEPPVNDQDASSPDIFSLPEGIESLSRASQYPELQTASLVYPTPPDGAATTGVIPTLSSDVFAEDIEHGSNFLQPNRQTQYSQPASKENELAVDFGPSAGHVVGSGLYDMNEDDDLFGDINGRDFGSKGITDADFSFFDDPDFDHGGGDGQTDPIHEISAFMDTDEPTMPSAVADQPSPEQTPALQIDIPQVTPINETPELQPDTAAPNDKTPAPPSPEDDKIRTISPPLSPVEVKKILFPEPQGGNQPIQMPGYYNAVAFKHNMSIWDQKYRANGKFGFTVRGMDAPKVATPGASDIPTIGLPRRSVKAKIGAVSKELDGHDGSPTSEEIGPMSSDSESSSAASVESDDSDAESGFSPATFSTRKRKRTRSNSGTSLALSQERAFMGAEQETPNHRPEDSIFLGNFLSTFSDWSMTGYFSLAQNQVSPVLLRRDIQVQIAQLLVDQVTQSSLDHKFDGTLGLSDYDDEAYTNQASLGDLTFVDGMDRLDLNSFISLQDTNLLSPPASSGANPRQSSQRKDAGKGTILKIPPPHLRVRRGKDFLETLPPAISFWETFGLEPAHGQKNISAYCIHPHFAAEAADSFLERLGLVYSGCNLGTHDRGDRSNLFDRGLGSWDSSLSVESRYLEVMKSLKAICEELGSAFLRSPPNKDSSLVIYIINPFTHAAASVDICSAFWFLFQKYVADADKQQAQQLNELVLQILPIDFVMSPESLVVPPQAEYLNLALEVYSRCPPKSFQPSLVNCAPPVLLADPIPRSIGFRLSSEGSSPLQEGKCLHIACSRSLDQRWISVAWSDSTGALQRNMSYCLRFRNSLATRTLLEVRGEIWRATRDIMERIQARWRVVIVNTDPVDQDEVDTWSNFAEQYGKAKSTTIDLVILSVNTTLDLLLEPPFLPIPMSVFNQHPSSTPVATPNIAANIASPDQSGNAPTPPGGGGAATNAPTPTDAFPEVESESLLTDICDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSINVIYTRRPPSSYDTLLREILGMHRDLATLARARGTRTVQKGTLPWHIATAVKAQTMLSYVM
Length1484
PositionKinase
OrganismAspergillus ellipticus CBS 707.79
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.375
Instability index53.73
Isoelectric point4.94
Molecular weight162230.62
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21469
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.78|      37|     276|    1143|    1194|       1
---------------------------------------------------------------------------
  413-  448 (36.17/ 8.53)	HQEPPVNdqdaSSPD..IF...SLPEGI.ESLSRA........SQYPeLQ...
  450-  490 (37.03/ 6.94)	..ASLVY....PTPPdgAATTGVIP.....TLSSDvfaediehGSNF.LQPNR
 1152- 1189 (62.59/29.18)	FQPSLVN....CAPP..VLLADPIPRSIgFRLSSE........GSSP.LQEGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.35|      34|     276|     697|     761|       2
---------------------------------------------------------------------------
  724-  761 (54.05/77.79)	KIGAVSK..ELDGHDGSPTSE..EIGPMSSDsessSAASVES
 1001- 1038 (52.31/18.94)	RLGLVYSgcNLGTHDRGDRSNlfDRGLGSWD....SSLSVES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.35|      59|     276|      50|     131|       3
---------------------------------------------------------------------------
   51-  116 (86.07/64.14)	RLKDLElqlrDRNCLVSSYPRRLCLWLfSATPGFESLTSLSPneGKDDQPSRLIIGSATLKVSSSG
  234-  292 (108.29/59.08)	RLRTPE....DESAVIHETPPGTDLWL.SPSGSIARLVTTNP..SRTNAPSPYPLGGGSLGNEKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.09|      26|      36|     603|     628|       5
---------------------------------------------------------------------------
  565-  604 (22.36/ 6.62)	TDPIHEISAFM.DTDEPTmpsavaDQ...PspeqtpalqidiPQ
  605-  642 (39.04/17.58)	VTPINETPELQPDTAAPN......DKTPAPpspeddkirtisPP
  643-  666 (31.85/12.86)	LSPVEVKKILFPEPQGGN......QPIQMP..............
 1322- 1347 (36.85/16.14)	STPV.ATPNIAANIASPD......QSGNAP...........tPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.84|      66|     900|     322|     411|       6
---------------------------------------------------------------------------
  322-  411 (96.27/94.13)	WVEVeVWepfysrlageiwrpndeSSSTLPLKRILwpaNYCFK.RTK..............SASSDSFGQMES...VCPVIGDPLDFAEkwrVTEKPTFTEASPKPPS
 1203- 1286 (99.57/50.72)	WISV.AW.................SDSTGALQRNM...SYCLRfRNSlatrtllevrgeiwRATRDIMERIQArwrVVIVNTDPVDQDE...VDTWSNFAEQYGKAKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.75|      27|     900|     491|     523|       8
---------------------------------------------------------------------------
  491-  523 (40.83/39.00)	QTQYsQPAskeneLAVDF.GPSAGHVVGSGLYDM
 1394- 1421 (43.92/25.68)	QTEY.RPA.....LASGYlLRRKGSTDGDGLYTM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21469 with Med13 domain of Kingdom Fungi
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