<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21468

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMATAPESSLEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDPTSNNASLAIQANYNEAFRQFIETREAFEGRLATMQGLEFIVSYDPLQAAAQPDGRFAHEPSNIWVIRKQTRRKRAGQDDEVEVLSTYFVVGDCIYMAPSVASVIGNRILSAVTSLTSLLKTASTLPTFTPSHGHTYLPPSAKQPDSAAQAAGTAAQQSKENTPMPDAPTKAPLVGSQVAQTGGSVYQDTRTLAESFSLLTQYGDEFMDENPLVGEPGSFLMSKAGDAAAAAGLSKQGPNAGGAAAARVATPQVRVDTPGRGSEKGAATPSAAALEDSKSRKKKVKVGGLS
Length334
PositionHead
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.310
Instability index46.91
Isoelectric point5.80
Molecular weight35447.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364143

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21468
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      17|      20|     231|     248|       1
---------------------------------------------------------------------------
  231-  248 (24.52/20.81)	QDTRTLAE..SFsLLTQYGD
  252-  270 (24.13/14.80)	DENPLVGEpgSF.LMSKAGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.41|      13|      17|     280|     295|       2
---------------------------------------------------------------------------
  281-  295 (19.86/15.52)	GPNAGGAAAArvATP
  301-  313 (23.55/ 7.63)	TPGRGSEKGA..ATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      16|      38|     128|     143|       4
---------------------------------------------------------------------------
  128-  143 (30.29/19.07)	LSTYFVVGDCIYMAPS
  169-  184 (32.15/20.64)	LPTFTPSHGHTYLPPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21468 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KAGDAAAAAGLSKQGPNAGGAAAARVATPQVRVDTPGRGSEKGAATPSAAALEDSKSRKKKVKVGG
2) TPSHGHTYLPPSAKQPDSAAQAAGTAAQQSKENTPMPDAPTKAPLVGSQVAQTG
267
173
332
226










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAARVATPQVRVDT
2) KGAATPSAAALEDSKSRKKKVKVGGL
287
308
301
333