<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21466

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDDANTGGLRHGPGNHDSRNELSCSAGEVTRLNGITDSQNSSLSLDGEDGSFGQHRVGTSSIYRMSRGLNEPPELPRIMQGFFPFSKLVTRSVQQCWNDLSDLIAELAEVQIHSHESNSLPISTSGKSPGNQSSENIRKKIRTLEFSHAKRAEFIKLLVLSQWSRQAADVSKLIDIQNFIRTRHQAYAGALQCIGDMKRDLVQAQVANPDLKTALEVLSKGKVASMSDLGYTPPKPLKARGTLKRLQRINRLIGVRLAVREEIPSLFRTYRIHDGRVTFIVPGEFELDLSIGEEDESSQFFFVDIHFLFLPSPPVPKGRILNELEITINDVLQSSGLIGCFNLLHGFVLTNKVNILFKQAIELARGPWTDVLRVELLHRTLVIQYWTLKPGAKSWLEIGIKRGCRRSNNESSELPSLGLRWIRDGEEVTCEDIDFDEEYLSMECLLRSTIALHVSQILSSAYISIRHSSLFSTGLLSLRAQLNRTEPGDCLLDVQLTKTRYIRVFIEPMSGMSILSATPSALERFDGDRNPDKSFVDDIVARVARLRCNAAIEEIESNLKMLGFEPLNSRAWKFDVRRIFPPNILRFTFFWHRLWEPNWAVAATSSMDGDSWWVIQFGPTVLAKSHAILDASVHSQSFFRSTQVVSHTFFPAMQHKINYTSLAALGHCLPGILTIHSNARYLEDLQSIKFYPPLHKLKIESDLQVPDIFIRYDTSNLPNAFQLAMPVRAKRRTHIKDTIRLAFNGIDPRKKVAIMVAYGNLVSPASAFGAPISNLDRSLVFQAKGSGFAIRLLAPAGQSIIINLIESLQKLECLLSILESLQRKKIGVRAFSLSSISFTYGQQRNFSASLNIDLSMSLSHVDLSPVELASRPESIFNLRLSIRFDHSSPHRRIQESLASSLNHVSTETGLENVVKLLSLTLPLMRALDQLMTNPSYNEPLKVQVTARNAKKYQIYYPDEKIRFQLVATSHLNRMVWILNDVNGQRNGVVHDNIKTNIQGTLYNSKGDGWRGLGNGVVAEIGSIGNLLREIEKCFAISQGQPGQKSTDGAAKIGKLNSLTPSVPLGEHGHIEGIEYPHHDLLATVPNNRSAQSKANTATQNEDIIMID
Length1112
PositionTail
OrganismAspergillus ellipticus CBS 707.79
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.190
Instability index49.22
Isoelectric point8.88
Molecular weight124294.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21466
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     276.55|      75|     572|     293|     398|       2
---------------------------------------------------------------------------
  293-  372 (118.17/82.18)	DLSIGE.EDESSQFFFVD..IHFLFLPSPPvPKGRILNELEITINDV.LQSSGLIGCFNLLHGFVLTNkvniLFKQAIELARGP
  867-  939 (110.06/62.70)	DLSPVElASRPESIFNLR..LSIRFDHSS..PHRRIQESLASSLNHV.STETGLENVVKLL.SLTLP.....LMRALDQLMTNP
  955- 1001 (48.32/44.53)	.........KKYQIYYPDekIRFQLVATSH......LNRMVWILNDVnGQRNGVV......HDNIKTN................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.05|      29|     336|     205|     238|       4
---------------------------------------------------------------------------
  205-  238 (39.00/41.63)	DLVqAQVANPDLKTALEVLSkgkvASMSDLGYTP
  543-  571 (48.06/33.39)	DIV.ARVARLRCNAAIEEIE....SNLKMLGFEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.00|      31|     336|     480|     510|       6
---------------------------------------------------------------------------
  449-  494 (37.52/30.50)	CLLRstialhvSQILSSAYISIRhsslfstgLLS.LRAQLNR....TEPGD
  495-  538 (36.48/29.39)	CLLD.......VQLTKTRYIRVFiepmsgmsILSaTPSALERfdgdRNPDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.22|      12|     572|     248|     261|       7
---------------------------------------------------------------------------
  248-  261 (16.64/17.08)	LKRLQRinRLIGVR
  823-  834 (20.58/13.13)	LESLQR..KKIGVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21466 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMDDANTGGLRHGPGNHDSRNELSCSAGEVTR
1
36










Molecular Recognition Features






MoRF SequenceStartStop




NANANA