<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21465

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGTFLRRCLLHRIDAAEFKSLARLLMQRCPIAEAPLLDVLLETRLATGIKWDPLLPLYIDCLCKMGLVQTSTVLNCLLKYSSIHDKPQPPGQEAVPIKQRHKCYTLMTDIRVVQDAMLSVSTGTTPKSFPEAVGIFHAIVDWIQAVVSWHNNHMDASHQTGGLMSSPDAVSLFESLGILLAALSGTSKGLEVLSAVTHESLKVKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFGLFGEPASKTLDVSMMENVNVNALQFEDSVMDGPVLNSRAGLYIYINAMLVGRPLVDDSMLLNYLSNRYGGHYQSLIEEIITATFDVLSNASYRSESSRSMFLFRSFLVNKLPSFIAAMLAASMVSLPMELCISHALSRLDPNTFPSFSQMFSMQSNTALSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPMGGPYNKDELVSQINANPERAEQLINEIESMEGNAGAIVGAITEVMHHLCNQKETMTLKNICNSLSRRVQALDVILLFRSARQVLQPLCTLLDAWHWDEDQGESQPVYDEFGSILLLVLTFKFRYDLRPCDIGIGGNNSFVFRLLEGGSGSEKLDDLNEKQNKNLGAWINALFIAEGISEETMSTCSPQEFYTLVTTLFSQSLGACEAGKLEFETLKGGFEYLLEPFLLPSLVLALNWLGNHIWETENDPTIPLKALQSLVTPSSISGEGREIHRTVLNITARSLEEQLKDVRSRHPSRTDIKPILDALEPYLSFQRSGSCHRSELESWTTHSPGGLLGSMRSTFQSLLLWSASPDMSMAPQSYTHRQLIAGIRIQGSSRVLAALVEELKLQNEAGNGALALDIAASLICAPLAESFAVDQNNYSQHPIDPTKEPLPQCPILTLRDALFLVHENIPKTSEKDPLRAEVIVRLYRRVNVLMTPPSQVPNLDMTNIIQNMQLGVGGPGQMDLEPSGGPNHDENISQILDNAAAAAAVGMDGGQNMGSMDSMGGMGNMGNIGLESSSGVDTSIDDVLNSVDISVGNPEFLDLDLEGLF
Length1030
PositionTail
OrganismAspergillus ellipticus CBS 707.79
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.032
Instability index50.61
Isoelectric point4.95
Molecular weight113166.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21465
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.55|      23|      28|     436|     462|       1
---------------------------------------------------------------------------
  418-  450 (22.85/13.29)	PESSiERLLgeNPmqtlpMGGpyNKDELVSQIN
  453-  478 (32.71/19.03)	PERA.EQLI..NE..iesMEG..NAGAIVGAIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.70|      17|      28|     863|     879|       3
---------------------------------------------------------------------------
  863-  879 (32.43/17.91)	PIDPTKEPLPQCPILTL
  891-  907 (28.27/14.76)	PKTSEKDPLRAEVIVRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.57|      25|      28|     259|     283|       4
---------------------------------------------------------------------------
  259-  283 (42.63/29.10)	VNVNAL.....QFEDSVMDGPVLNSRAGLY
  284-  313 (37.94/25.02)	IYINAMlvgrpLVDDSMLLNYLSNRYGGHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.06|      12|      28|     728|     739|       5
---------------------------------------------------------------------------
  728-  739 (22.89/15.48)	RSRHPSRTDIKP
  758-  769 (23.17/15.77)	RSELESWTTHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.06|      16|      28|     814|     829|       6
---------------------------------------------------------------------------
  814-  829 (24.66/16.26)	SRVLAALVEELKL.QNE
  842-  858 (23.40/15.05)	SLICAPLAESFAVdQNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.43|      28|      36|     350|     377|       7
---------------------------------------------------------------------------
  350-  377 (49.66/36.89)	NKLPSF..IAAMLAASMVS.LPMEL...CISHAL
  383-  416 (37.77/26.04)	NTFPSFsqMFSMQSNTALSdVRQEFlfaCASHKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.84|      37|      78|     912|     949|       8
---------------------------------------------------------------------------
  912-  949 (60.38/45.68)	NVLMTPPSQVpNLDMTNIIQNMQLGVGGPGQMDLEPSG
  992- 1028 (57.46/37.98)	NIGLESSSGV.DTSIDDVLNSVDISVGNPEFLDLDLEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      14|      36|     128|     142|       9
---------------------------------------------------------------------------
  128-  142 (22.25/17.00)	TGTTPKSfPEAVGIF
  166-  179 (26.12/14.60)	TGGLMSS.PDAVSLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      21|      73|     558|     583|      10
---------------------------------------------------------------------------
  558-  583 (34.34/33.10)	FRYDLRPCDIGiggnnSFVFRLLEGG
  634-  654 (37.59/22.86)	FSQSLGACEAG.....KLEFETLKGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.65|      34|     623|      41|      79|      12
---------------------------------------------------------------------------
   42-   79 (50.28/35.27)	LLDVLLETRLATGIKW..........DPLLPLyiDCLckMGLVQTSTV
  658-  701 (51.37/21.07)	LLEPFLLPSLVLALNWlgnhiwetenDPTIPL..KAL..QSLVTPSSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21465 with Med5 domain of Kingdom Fungi
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