<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21458

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMEDGINVDDLFGEPASLELGLPTTTSTKGLAERLDEMRLLGCCQKIAWSKLGCIAYIAQDPSKVHVRYLQCQPTDGKWTLSDETPLLPVTEAHGGTALVHLSWNESGSELAVVDLSGRLSIYSIPIALNSVNGLRPPSLEPDDSAQIVGMLWLNTQRSVHAFYQAAKVQGRWAYSPYRRRPIGPFHPANKAALVYITRSGMIKLLYQNPDGKWAEISAELKNTSYSDRMLTHAALTATQNGILVATYSACQKICVYRVQINWNPPQYDPAQQPKQTPPQFPVPSFRFAHCKVETSCSVPGPVRNSGDPSDHLQPPFPNSLYCLTRLDVILPTSDNAAGSSATPWIVATFSILPQIAPDHPHQQGPSSIIVRWQLESAPLTLHPKFDEVTTKRNSMQLKAKAVLNRLEDIFCDRYVVSIDHIEYANVLAVTYDDSSISFYDPKTMAAFNGVDDANTVTSLAQAGFHYSPDTPGLHISFSPSACAAVVLDSSGHVQLRVLEHSYGADNGLYDENKFSAAIAALTLAFCRGCGSEVNTDDILLILIRQLSPDAQTSFINEVYRALPINCNFTVEQDKLMNHPYIPRCLSIQAALGNKGKIQQRGFASSVSWTILQLRHASILYPFFFQYNKGVQAEPHDPDVLRMVLGNTRWALDFSLYILHELFNLADEFEDVSSDQEAFNQKLKSTNSLSLIILLSSMSRAFLRFICRGLRGIHAGYANAPLTGDARVYYTEICQAVETSPAAIDVYEKFLAGVDSAVRHAYHGAGFGDAERPGPEKELLVSARIPPVLVTAVSTILRQTIPSLRSDVDRMDIYMRDYSWLGLDSDRRTELYRRTRGLDIIKKIPIRPSPSTNGTAQPSLGETKSKDGHAATGVAVGQPLRRRCVRCCEVSEGSYPPRSVLAFRMIFKLGHLRACICCGMWILESGSGSAEVGKPIGA
Length941
PositionTail
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.144
Instability index42.32
Isoelectric point6.59
Molecular weight103728.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21458
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.25|      59|     300|     427|     491|       1
---------------------------------------------------------------------------
  427-  491 (85.34/68.85)	YANV.LAVTYDDSSISFYDpKTMAafnGVDDAnTVTSLAQAGFHySPDTPGLHISFSPSACAAVVL
  733-  792 (98.91/57.29)	YTEIcQAVETSPAAIDVYE.KFLA...GVDSA.VRHAYHGAGFG.DAERPGPEKELLVSARIPPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.94|      15|     302|      63|      77|       2
---------------------------------------------------------------------------
   63-   77 (30.51/24.50)	QDPSKVHVRY.LQCQP
  367-  382 (24.42/17.85)	QGPSSIIVRWqLESAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     290.89|      69|     435|     125|     218|       3
---------------------------------------------------------------------------
  125-  193 (123.65/58.47)	IYS.IPIALN.SVNG...LRPPSLEP.DDSAQIVGMLWLNTQRSVHAFYQ....AA.KVQG..RWAYSPYRR.RPI.GPF.HPAN
  259-  321 (89.82/61.25)	VYR.VQINWN..........PPQYDPaQQPKQTPPQFPVPSFRFAHCKVE....TScSVPGpvRNSGDPSDHlQP...PF..P..
  562-  631 (77.42/30.85)	VYRaLPINCNfTVEQdklMNHP.Y........IPRCLSIQAALGNKGKIQqrgfAS.SVS....WTILQLRH.ASIlYPFfFQYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.86|      29|     133|      79|     111|       8
---------------------------------------------------------------------------
   79-  111 (45.22/41.55)	DGKWT.LSDEtplLPVTeAHGGTALVH..LSWNESG
  214-  245 (43.64/26.92)	DGKWAeISAE...LKNT.SYSDRMLTHaaLTATQNG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21458 with Med16 domain of Kingdom Fungi
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