<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21454

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASSASFRVGPPSPASPAPESLKETPQFPTISSDQIPQTPTSPPLMSVSAHNYATHFVPSQTSPSQTTSQSTSLSSPPSSAPMSNQPSQQPVVGGSANSFPTPASSVSGHIPGTTSFDEPDAPAKLLGSGPSEGGATSTGGAFATTQRAEHRRTDHDRQPGGDSEGVVRDQTATGLPVHSDAMDIDREVPGSSDGSMSLESLQHDFSSAFHLCKSSYTATGPDPSLDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKHEPGAPGGLIHMTMWPEEEWQNQKVFGKEMKVADMDSALHALQMKAMKMEPGAVPNSEQWEDVLGHEKPSKHAGGGGDAGKKAVAPPNGARMQANGTPGPGISDAERSRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSASDGIGKKKRKKDHASKISTPLPDRSGSYGVGMFGIGAR
Length459
PositionHead
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.05
Grand average of hydropathy-0.740
Instability index53.09
Isoelectric point6.32
Molecular weight48113.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21454
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.40|      40|      64|       2|      45|       1
---------------------------------------------------------------------------
    2-   45 (58.07/39.19)	SDRASSASFRVGppSPASPAPESLKETPQfPTI..SSDQIPqTPTS
   67-  108 (68.33/31.82)	PSQTTSQSTSLS..SPPSSAPMSNQPSQQ.PVVggSANSFP.TPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.47|      15|      68|     273|     287|       2
---------------------------------------------------------------------------
  273-  287 (30.60/13.58)	GRNKPVKHEPGAPGG
  344-  356 (26.29/10.65)	GHEKPSKHAGG..GG
  365-  378 (21.57/ 7.44)	PPNGARMQANGTPG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     198.07|      62|      66|     122|     187|       3
---------------------------------------------------------------------------
  120-  184 (99.32/53.90)	FD.EPDAPAKLLGSGPSEGGATSTGGAFATTqRAEHRRTDHDrqPGGD.....SEGVVRDQTATGLPVHSD
  186-  253 (98.75/42.75)	MDiDREVPGSSDGSMSLESLQHDFSSAFHLC.KSSYTATGPD..PSLDlislyGLGPVAKSVARMDPVTGE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21454 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAFYSASDGIGKKKRKKDHASKISTPLPDRSGSYGV
2) LHALQMKAMKMEPGAVPNSEQWEDVLGHEKPSKHAGGGGDAGKKAVAPPNGARMQANGTPGPGISDAERSRPSRGRKRHYDDNSFVGYG
3) MSDRASSASFRVGPPSPASPAPESLKETPQFPTISSDQIPQTPTSPPLMSVSAHNYATHFVPSQTSPSQTTSQSTSLSSPPSSAPMSNQPSQQPVVGGSANSFPTPASSVSGHIPGTTSFDEPDAPAKLLGSGPSEGGATSTGGAFATTQRAEHRRTDHDRQPGGDSEGVVRDQTATGLPVHSDAMDIDREVPGSSDGSMSLES
416
318
1
451
406
204










Molecular Recognition Features






MoRF SequenceStartStop




1) DGIGKKKRKKDHASKIST
423
440