<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21453

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVIDGFSQIYWRIYTEEPGITNIPGESPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLCLWTFSSTPGFEALASVAASRGKDDTGRLLVGSTTLKVSSSGSVSSSDLVKNLSVEPQHATGAAGPQRPSAPTPFVTIYASFISALMGTLSLQLIQQVGAVPLGSRTLLTLDERGLHETVGHSAESSTFAPSLTTLQVQLISAGKLTVALQTVPQPGLLRLCKSEDSPESHDTPPGTDLWLSPSGSIARLVTTRPAQRVGSSPYPYSTGGVGSDRSDPVNRKQWMANVLGWLANFGLPVDGIGEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSASSDSYGEMESVCAVIDNPLEFAEKWHVLEKPNLNETSPKPLSIAQESETKDQDAPTPDTAGLPEGLESLSRASQYPDLQTAGLVYPTPPDGATTAGLNPTTVSDAFSEDLYNSSAFPQQTRQISFGQPHSKDRSAVDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDEPGFDRMDEGDHPDPMHEMPDFSETDQLEAQPTPAEHTFPGLVQEAVGDQMFEPEADKMDVTTDAQSEQPPHEKDVPLPSPQEDNVATISPPLSPVEVKKFLFPEPQAESHPSPQQGQMPGYYKPIHFKQGISSWDQKYSTEGKFWFKMRGKDTIENATTTSSDIPTIGLPRHATISKKSAGIKPFDEHGSPLDDIFQEATSDSELSDAASIDGAESEAESDLSPATYPTRKRKRSLSNSGTSLALSPEKTSINAEQDTATQRPEDSVFLGNFLSTFSDWSLTGYFSLSQNQTFPALLQKELQVQIAQILVDQITQSSLDHKYDGTVGLSGCGNEAHSPQSVDDESFMGGIERLDLNSFVSLQDPVALSPSTQARQSSQRKDTSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTATEAADTFLDRLGLVYSGCNLGSHDRGNSSNLFNRGMGSWDIDLSHTRYSSIMQSLKTICEGLGTALLQSPPDKENNLVVYIVNPFAHAAALVDICSAFWILFQRYVADADRQQARQLNELVLQIVPLDFLMSNESLVVPPQAEYLNLALEVYSRCPPKSPHSSLVNGAPPMLLAEPLPKIINFKLSSEKISPLQEGRCLHIACSRSQDQRWMSVAWSDNTGALQRTMSYCLRFRNSSVVRSIAEVRAEIWGATKDIMDRTQARWRVIVANTDPVDQEEVDTWTALTEQYNKSRSANLELTILSVGATPDLTLEPPFLPLPMSAVNPLASTTPIATPNPSISSPDQISTAPTPPSAANVPPNAPTPTDTNPEIESESLLMDICDETWGVVLSHRLNSSMHQTEYRPALASGYLLRRRGSTDGDGVYTMGANIIYSRRSSASYDAVLREILSMYRDLATLARARGTRAVQQGTLPWHIATVVKAQALLSYVL
Length1482
PositionKinase
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.372
Instability index52.08
Isoelectric point4.88
Molecular weight161612.81
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21453
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     508.95|     144|     181|     335|     514|       1
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  335-  499 (219.87/169.82)	GE.TWRPNDgglstlPLKRilwPaiycfRRTKSAS.SDSYGEME....SVCAVIDNPLEFAEKwHvlekPNLNETS.P...KPLSIAQESETKDQDAPTPDTagLP.....EGLESLSRA.SQYPDL.QTAGL.VYPTPPDGAT....TAGLNP.....TTVSDAFSEDLYNSSAFPQQTRQISFGQPHSKD
  518-  628 (161.53/107.66)	GSgLYDTND.........................D.DDLFGDMNerdfGAKGITDADFSFF..................................DEPGFDR..MD.....EG.DHPDPM.HEMPDFsETDQLeAQPTPAE.HT....FPGLVQ.....EAVGDQMFEP..EADKMDVTTDAQSEQPPHEKD
  630-  757 (127.55/65.97)	...............PLPS...P.....QEDNVATiSPPLSPVE....VKKFLFPEPQ..AES.H....PSPQQGQmPgyyKPIHFKQGISSWDQKYSTEGK....fwfkmRGKDTIENAtTTSSDI.PTIGL......PRHATiskkSAGIKPfdehgSPLDDIFQEATSDS...................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.52|      56|     121|     765|     820|       2
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  765-  820 (91.34/56.80)	IDGAESEAESDLS..PATYPTRKRKRSLSNSGTSL....ALSPEKTSINAEQ...DTATQRPEDS
  827-  873 (50.91/27.83)	...........LS..TFSDWSLTGYFSLSQNQTFP....ALLQKELQVQIAQilvDQITQSSLD.
  882-  937 (71.27/42.42)	LSGCGNEAHSPQSvdDESFMGGIERLDL.NSFVSLqdpvALSP.....STQA...RQSSQRKDTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.44|      47|     858|     279|     326|       3
---------------------------------------------------------------------------
  279-  326 (85.04/57.39)	YSTGGVGSDRSDPVNRKQWM..ANVLGWLANFGLPVDGIG................EDSWVEVeVW
 1144- 1208 (74.41/45.39)	YSRCPPKSPHSSLVNGAPPMllAEPLPKIINFKLSSEKISplqegrclhiacsrsqDQRWMSV.AW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.34|      72|     858|      49|     121|       4
---------------------------------------------------------------------------
   49-  121 (113.01/63.78)	LSRLKDLELRLRNLDCLVSSYPRRLCLW.TFSSTPGF...EALASVAASRGKDDTGRLLVGSTTLkVSSSGSVSSSD
  941- 1016 (122.33/65.78)	ISRLGPPHLRVCRGKDFLETLPPAIPFWeTFGLGPAHgqkDILAYCIHPHTATEAADTFLDRLGL.VYSGCNLGSHD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.47|      21|    1188|     125|     147|       5
---------------------------------------------------------------------------
  125-  147 (35.54/22.24)	NLSVEPQHATGAAGPqrPSAPTP
 1337- 1357 (40.94/20.13)	QISTAPTPPSAANVP..PNAPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.24|      13|      15|    1244|    1256|       9
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 1244- 1256 (23.78/15.01)	ATKDIMDRTQA.RW
 1261- 1274 (19.45/10.90)	ANTDPVDQEEVdTW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.59|      27|      56|     150|     176|      12
---------------------------------------------------------------------------
  150-  176 (45.11/27.09)	TIYASFISALMGTLSLQLIQQVGAVPL
  208-  234 (44.48/26.61)	TLQVQLISAGKLTVALQTVPQPGLLRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21453 with Med13 domain of Kingdom Fungi
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