Description | Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MDFPGGSVTNIRVIDGFSQIYWRIYTEEPGITNIPGESPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLCLWTFSSTPGFEALASVAASRGKDDTGRLLVGSTTLKVSSSGSVSSSDLVKNLSVEPQHATGAAGPQRPSAPTPFVTIYASFISALMGTLSLQLIQQVGAVPLGSRTLLTLDERGLHETVGHSAESSTFAPSLTTLQVQLISAGKLTVALQTVPQPGLLRLCKSEDSPESHDTPPGTDLWLSPSGSIARLVTTRPAQRVGSSPYPYSTGGVGSDRSDPVNRKQWMANVLGWLANFGLPVDGIGEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSASSDSYGEMESVCAVIDNPLEFAEKWHVLEKPNLNETSPKPLSIAQESETKDQDAPTPDTAGLPEGLESLSRASQYPDLQTAGLVYPTPPDGATTAGLNPTTVSDAFSEDLYNSSAFPQQTRQISFGQPHSKDRSAVDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDEPGFDRMDEGDHPDPMHEMPDFSETDQLEAQPTPAEHTFPGLVQEAVGDQMFEPEADKMDVTTDAQSEQPPHEKDVPLPSPQEDNVATISPPLSPVEVKKFLFPEPQAESHPSPQQGQMPGYYKPIHFKQGISSWDQKYSTEGKFWFKMRGKDTIENATTTSSDIPTIGLPRHATISKKSAGIKPFDEHGSPLDDIFQEATSDSELSDAASIDGAESEAESDLSPATYPTRKRKRSLSNSGTSLALSPEKTSINAEQDTATQRPEDSVFLGNFLSTFSDWSLTGYFSLSQNQTFPALLQKELQVQIAQILVDQITQSSLDHKYDGTVGLSGCGNEAHSPQSVDDESFMGGIERLDLNSFVSLQDPVALSPSTQARQSSQRKDTSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTATEAADTFLDRLGLVYSGCNLGSHDRGNSSNLFNRGMGSWDIDLSHTRYSSIMQSLKTICEGLGTALLQSPPDKENNLVVYIVNPFAHAAALVDICSAFWILFQRYVADADRQQARQLNELVLQIVPLDFLMSNESLVVPPQAEYLNLALEVYSRCPPKSPHSSLVNGAPPMLLAEPLPKIINFKLSSEKISPLQEGRCLHIACSRSQDQRWMSVAWSDNTGALQRTMSYCLRFRNSSVVRSIAEVRAEIWGATKDIMDRTQARWRVIVANTDPVDQEEVDTWTALTEQYNKSRSANLELTILSVGATPDLTLEPPFLPLPMSAVNPLASTTPIATPNPSISSPDQISTAPTPPSAANVPPNAPTPTDTNPEIESESLLMDICDETWGVVLSHRLNSSMHQTEYRPALASGYLLRRRGSTDGDGVYTMGANIIYSRRSSASYDAVLREILSMYRDLATLARARGTRAVQQGTLPWHIATVVKAQALLSYVL |
Length | 1482 |
Position | Kinase |
Organism | Aspergillus uvarum CBS 121591 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.372 |
Instability index | 52.08 |
Isoelectric point | 4.88 |
Molecular weight | 161612.81 |
Publications |
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.
ECO:0000256 RuleBase:RU364134 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21453 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 508.95| 144| 181| 335| 514| 1 --------------------------------------------------------------------------- 335- 499 (219.87/169.82) GE.TWRPNDgglstlPLKRilwPaiycfRRTKSAS.SDSYGEME....SVCAVIDNPLEFAEKwHvlekPNLNETS.P...KPLSIAQESETKDQDAPTPDTagLP.....EGLESLSRA.SQYPDL.QTAGL.VYPTPPDGAT....TAGLNP.....TTVSDAFSEDLYNSSAFPQQTRQISFGQPHSKD 518- 628 (161.53/107.66) GSgLYDTND.........................D.DDLFGDMNerdfGAKGITDADFSFF..................................DEPGFDR..MD.....EG.DHPDPM.HEMPDFsETDQLeAQPTPAE.HT....FPGLVQ.....EAVGDQMFEP..EADKMDVTTDAQSEQPPHEKD 630- 757 (127.55/65.97) ...............PLPS...P.....QEDNVATiSPPLSPVE....VKKFLFPEPQ..AES.H....PSPQQGQmPgyyKPIHFKQGISSWDQKYSTEGK....fwfkmRGKDTIENAtTTSSDI.PTIGL......PRHATiskkSAGIKPfdehgSPLDDIFQEATSDS................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 213.52| 56| 121| 765| 820| 2 --------------------------------------------------------------------------- 765- 820 (91.34/56.80) IDGAESEAESDLS..PATYPTRKRKRSLSNSGTSL....ALSPEKTSINAEQ...DTATQRPEDS 827- 873 (50.91/27.83) ...........LS..TFSDWSLTGYFSLSQNQTFP....ALLQKELQVQIAQilvDQITQSSLD. 882- 937 (71.27/42.42) LSGCGNEAHSPQSvdDESFMGGIERLDL.NSFVSLqdpvALSP.....STQA...RQSSQRKDTS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 159.44| 47| 858| 279| 326| 3 --------------------------------------------------------------------------- 279- 326 (85.04/57.39) YSTGGVGSDRSDPVNRKQWM..ANVLGWLANFGLPVDGIG................EDSWVEVeVW 1144- 1208 (74.41/45.39) YSRCPPKSPHSSLVNGAPPMllAEPLPKIINFKLSSEKISplqegrclhiacsrsqDQRWMSV.AW --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 235.34| 72| 858| 49| 121| 4 --------------------------------------------------------------------------- 49- 121 (113.01/63.78) LSRLKDLELRLRNLDCLVSSYPRRLCLW.TFSSTPGF...EALASVAASRGKDDTGRLLVGSTTLkVSSSGSVSSSD 941- 1016 (122.33/65.78) ISRLGPPHLRVCRGKDFLETLPPAIPFWeTFGLGPAHgqkDILAYCIHPHTATEAADTFLDRLGL.VYSGCNLGSHD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 76.47| 21| 1188| 125| 147| 5 --------------------------------------------------------------------------- 125- 147 (35.54/22.24) NLSVEPQHATGAAGPqrPSAPTP 1337- 1357 (40.94/20.13) QISTAPTPPSAANVP..PNAPTP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.24| 13| 15| 1244| 1256| 9 --------------------------------------------------------------------------- 1244- 1256 (23.78/15.01) ATKDIMDRTQA.RW 1261- 1274 (19.45/10.90) ANTDPVDQEEVdTW --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.59| 27| 56| 150| 176| 12 --------------------------------------------------------------------------- 150- 176 (45.11/27.09) TIYASFISALMGTLSLQLIQQVGAVPL 208- 234 (44.48/26.61) TLQVQLISAGKLTVALQTVPQPGLLRL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KFWFKMR 2) PGYYKPIHFKQGI 3) SFFDEPGFDRM 4) VKKFLFP | 697 673 550 651 | 703 685 560 657 |
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