<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21452

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGIFLHRCLLHRIDAAEFKSLSRLLLQRCPITEALLLDVLLETRLSTGIKWDPLLPLYIDCLCKMGLVQTSTVLNALLKHSSIHDKHQSSSVEAYPGKKSRKCYTLMTDIRVVQDAMLSVSTGSVPKSFSEAISIFTAVIDWIQAVVAWNSSHIDSGHQSPGLISSPDAVSLFESLGILLAALSGTTKGLEVLSADSQEALKVKLGQALSAYLPISVEVSLPLRNRLDSLQKEFNLYGEPPAKPLDVSMMEGVNVNALQFEASVLDGPMINSRAGLFVYINAMLIGRPLVDDSMLLNYLSSRYGGHYEVLIEETITAAFDVLSNASYRSESNRSMFLFRSFLVNKLPAFFAAMLAASMVTLPMELCISHALGRLDPNTFPSFSQMFTMQSNTALSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDDLVNQINANPERAEHLIGEIESMEGNAGAIVGAIIEVMHNLCNQKETMTLKNICNSLSRRPQAMDVILLFRSTKQVLQPLCSLLDAWHWDEDQGESQPVYDEFGSILLLVLAFIYRYGLRAQDLGLGGSNSFVLQILGSGSCSQKLDSLSDKQNKNLGGWITALFIAEGISEETMSACSPQEFYLLVATLFSQSLGACEAGKLEFDTLKGGSEYLLEPFLLPSLVLALNWLGNHIWETEGDPSIPLKALHSLVNPTSISGEAKEIHRTVLNMTARGLEEQLKDVRARHPSRTDIKPILDALEPCLSFERSGSCHRSELDSWTSHSPGGLLGSIRSAFQSLVLWSASPHVSVAPHSYTHRQLVTGVLLLGATRVLGALVEELKLQTETGSGDVALDIAATLICAPMAEHFAIDQNNHSHQPLDPTKESFPRCPILTLRSALNLLHDNIPKISEKDPLRAEVIVRLNRRVNALMTPPAQVPNLDMNNIIQHMQLGVGGPGQMDLDPQGASGHGVTDDDAANLNRMLDNAAAAAAVGMDGGQTMGGMGLESSSGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF
Length1024
PositionTail
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy0.034
Instability index46.73
Isoelectric point5.08
Molecular weight111510.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21452
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      24|      72|     926|     949|       1
---------------------------------------------------------------------------
  926-  949 (45.48/23.48)	MNNIIQHMQLGVGGPGQMDLDPQG
  999- 1022 (39.89/19.79)	IDDVLNAADMAVGNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.18|      42|      68|     325|     368|       2
---------------------------------------------------------------------------
  325-  368 (63.33/50.96)	FDVLSNASYrSESnRSMFLFRSFLVNKLP.AFFAAMLA.ASMVTLP
  392-  435 (65.85/43.20)	FTMQSNTAL.SDV.RQEFLFACASHKLIPeSSIERLLGeNPMQTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.02|      50|      72|     183|     235|       5
---------------------------------------------------------------------------
  183-  223 (42.07/31.99)	..................................GILLAALSGTTKGLEVLSADSQEALKVKLGQALSAYlPIsV
  224-  296 (66.53/46.05)	EVSLPLRNrLDSlqkefnlygeppakpldvsmmeGVNVNALQFEASVLDGPMINSRAGLFVYINAMLIGR.PL.V
  684-  706 (24.42/ 9.66)	DPSIPLKA.LHS......................LVNPTSISGEAK.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.30|      47|     620|     114|     160|       6
---------------------------------------------------------------------------
  114-  160 (81.07/43.97)	TDIRVVQDAM...LSV.STGSVPKSFSEAIS......IFTAVIDWIQAVVAWNSS.HI
  735-  792 (62.23/32.31)	TDIKPILDALepcLSFeRSGSCHRSELDSWTshspggLLGSIRSAFQSLVLWSASpHV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21452 with Med5 domain of Kingdom Fungi
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