<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21450

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDTANIGRQIQGSPNDSQNGVSCSAAEKAPLKGPAVVQNGSLLAAGPEKGSVYRTDASTVTSVLAKTRELPELPHVTQGFFPFSILLNRSAQQCWNDLLDLITELAEIQVAPNDPGHASVPIVGKPPGNQSSENIQKKLRVLEFAHAKRADFIKLLVLSQWGRQAADVSKLIDIQNFIRTRHQAYTGALQCIGEMKKDLVRAQVANPDIRTSLEVLSKGKVASMLTLGYKPPKLLAPRRALRKLQKVNRLLCTRLALHDELPPSFQTYRIHDGRVTFIVPKEFELDLSIGEGSGLSQFFFVDIRLLFHPSSPIPKGRIFNELESKVNDVLQTRGLPGCFDLLHNLVLTNKINVLFKQATEMARGLWADVLRIELLHRTVVVHYWARKPGSKSWVEIGINSGRRGSMHGGPVPPYLGLRWIKDGEEVNSGLVDFDTANMSMERLLRSVIALHISHTVSSAYHSISQSLLYSTSTLSLRAQLTTTEPGNCLLDVQLTETRYLRVSVEPMSGANVFSTTPNVLERPDNDRLADKPAVDDIVNRVARLRCIAAIEEIECYLQMLGFDVINPRMLNIDVRRVFPSNVLRFSFFSHKSWEQNWVVAGTSSMDGDNWWLVQLRPGVVAKRHSAYDVKLGSRPAFRLAQVVSNTFISFRLDKSYMSFANLGHSLSGILTIYANSRYLADLDAIQSCPPAHKLRIEAGFQIPDISLRYEPAKLPNALHLVLPTGIRQKGFIRETIRLTFLGIDSQTNLSIIGAYGRLNIPVKAFSALMSKWDRSLVFQESHNGFAIRLLAPTGRPVIISLVEDLQRLECVLSVLNTLQRKKIEVTSISLSGISFTYGPRRDLTARLEVEIKRNPSLSEADAAELATMSDSIFRLQLGIRFDSTNPHRRIQGSLASSLNRTSVEASIETIAELLTSTLPLMRALDHIMDNTSRNEPLKVQVTVRNAMTYAIHYPDANLRFRLVARIRSNRLVWVLRNVSSSESSSDQVNSMSKVQQSLYDSKGEGWRGLGNGVIAQVDRVGNLLGELHRCIAASVPNTSLNKVGTRESSTITPTQATALSEVASGVATKPVRQDSSHPAYLQERTTQHSGSVASNTADVIMID
Length1103
PositionTail
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.143
Instability index44.29
Isoelectric point9.46
Molecular weight122256.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21450
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     273.97|      63|     149|      40|     106|       1
---------------------------------------------------------------------------
   40-  103 (104.05/64.28)	GSLLAAGPEKGSVYRT.....DASTVTSVLAKTREL....P...ELPHVTQGFF.PFSILLNRS...A...QQCWNDLLdLIT
  187-  253 (75.93/40.73)	GALQCIGEMKKDLVRAqvanpDIRTSLEVLSKGKVA....S...ML...TLGYK.PPKLLAPRR...AlrkLQKVNRL..LCT
  262-  312 (45.99/22.77)	.......PPSFQTYRI.....HDGRVTFIVPKEFELdlsiG...EGSGLSQFFFvDIRLLFHPS...S...P...........
  315-  370 (48.00/24.15)	.........KGRIFNE.....LESKVNDVL.QTRGL....PgcfDLLHNLVLTN.KINVLFKQAtemA...RGLWADVL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.90|      62|     445|     429|     495|       3
---------------------------------------------------------------------------
  429-  495 (86.89/76.59)	GlVDFDTANmsMERLLRSVIALHISHT.VSSAYHSISQsLLYSTSTLsLRA..QLTTTEPGNCLLDVQLT
  878-  942 (96.01/63.53)	G.IRFDSTN..PHRRIQGSLASSLNRTsVEASIETIAE.LLTSTLPL.MRAldHIMDNTSRNEPLKVQVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.18|      30|     125|     840|     869|       4
---------------------------------------------------------------------------
  840-  869 (49.32/28.69)	RRDLTARLE....VEIKRNPSLSEADAAELATMS
  959-  992 (45.86/26.21)	RFRLVARIRsnrlVWVLRNVSSSESSSDQVNSMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.86|      53|     161|     616|     673|       6
---------------------------------------------------------------------------
  616-  673 (80.00/79.65)	RPGVVAKRHSAYDVKL...GSRPAF........RLAQVVSntfISFRLDKSYMSFANLghSLSGILTIY
  774-  837 (76.87/58.67)	RSLVFQESHNGFAIRLlapTGRPVIislvedlqRLECVLS...VLNTLQRKKIEVTSI..SLSGISFTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.13|      21|      96|       9|      30|       7
---------------------------------------------------------------------------
    9-   30 (33.57/24.17)	QIQGSPNDSQNgVSCSAAEKAP
  107-  127 (39.56/23.68)	EIQVAPNDPGH.ASVPIVGKPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.31|      33|     667|     392|     428|       8
---------------------------------------------------------------------------
  392-  428 (57.36/47.91)	SWVEIGINSG..RRGSMHggpvPPYLGLRWIKDGEEVNS
 1060- 1094 (51.95/32.68)	SEVASGVATKpvRQDSSH....PAYLQERTTQHSGSVAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21450 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KVGTRESSTITPTQATALSEVASGVATKPVRQDSSHPAYLQERTTQHSGSVASNT
1042
1096










Molecular Recognition Features






MoRF SequenceStartStop




NANANA