<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21448

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSAGVQPWSRSMRAPNNGLGRVEAFQALNQSEPQSEKPPMPVPPSLPRQPAVIDLTTIPGDAQESEPPTKRLKLDVTSGAYAATGSPAPVSNGEARTTPGTATAKPQSLTWRGRPAWSFQALLSETTGAVEVKDDDASAQGKTSSSPPPLPLLPWKYTPQETPATDATKIAEIAPVKEVKTTPYRIEVPTIAPKIKGEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNMVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVPRAIWLARCVGANEIRAFKRKGTSGALALGLESKWVRDWTATVQQFLDGVVGICGAADWKVKMTYAVSLTSRLFFERLLDHDQYLSWFLLSLENASLNTIPVWLLMLGIYWSNIMRYRKRGRKLAEVLLEKLRQIKKSGHPETLQPLVDRLSRCIRRLVLEHTSSLILPNSWMTYKELISSCLNFKETPDQTMFHNLVERNSRVQLLKSQQEAKARLPQQKVISLFDSLRSAHDVTATASACLDAVDDKTVLVSKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGIDIESHILNFVAGFDSNSRLNMEHIYHIFSELVRSQTFSVGRYLQWLMAKGLAHSPASENEAISSELRLLIQLPSHRLPEHVRNLRNMLIDRAGFSLEEENSLVAKLQMSIAGRLPHIFGSERSGVPKTNLSLPAELTWAVKSEIGLWIRRGVAEHYRKPGRYSSASCSWTHVPSRRYSNIPFLSDSGISALTPAEFCVIREILEGFGDLSMLADVLKQATTCDNSIVLASVADTVNYHFDTFCVISAVHDLFKGLVESYVRLKRFGAPSLDLIFSLIELGLRVPSEFNTVALLRQDLARIENRAAVAAPSPLSDHISVSTGQIDSLFQEKLDQTLLSGGGMDESTMDTSFASLTKALQDGHKKLSANEICRYMAYLRTFHPKRFDAMLVRWVCGLLKSQTRSTMARILPPLIGVGCVTIHAFVALVKKLLQSEKVVAVIPSVAELKLDLFELLVPPKHDQSRLADMVTYRFRLAQQEFLAKHPEESLDIIRDVVPLIGSENTDCLYGSRRDDLTECATMLLQLLLTQNPERIVQSCLQKFIGQHTASTALLQKALNSLLGFDSDASDKTAPEAEKVIRMNNDFSLPFCQLKLQLLFNAEAAGQDNNSIVDVMFKAAVADTKSHNDHWYGLVSLMSHDAIQQIRERAERSFFSIPMFEENSDSLQSIEAARLYLTMIEKLAPCIPEAGVPTVVPVLVEKMEFLLQKFVAMQANHTGAGDGRPTNQASPSFERSLAFWFSALLRIVVIHRASFNTPGLAPRSHGLPEQTRLLISIFCISLARLPNRVLRLYPSADYFPQSKPVESYRPCPGILLQTHALDVAACLVDIFPDEARQQCARFLKEKCPPFLQFQNDARFLYLLGPIVDSSNPPQPTSLPSPAAGGSTPTPSGSLAYGQQTPQQSSTAVPSGLSAGLSEGVNCIASHLRVQYRGRAIGAYPVRPWELLEDAAPIVGMNDTALSLKYFDARRVRA
Length1591
PositionKinase
OrganismAspergillus uvarum CBS 121591
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.178
Instability index51.24
Isoelectric point9.01
Molecular weight176734.08
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21448
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.36|      49|     433|     521|     569|       1
---------------------------------------------------------------------------
  521-  569 (81.81/51.19)	FKETPDQTMFHNLVERNSRVQ.....LLKSQQEAKARLPQQKVISLFDSLRSAH
  949- 1002 (78.55/48.86)	FQEKLDQTLLSGGGMDESTMDtsfasLTKALQDGHKKLSANEICRYMAYLRTFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     205.48|      50|     433|       8|      57|       2
---------------------------------------------------------------------------
    8-   57 (87.47/52.11)	GVQPWS.RSMRAP.NNGLGRVEAFQALNQSEPQSEKPPMPVPPSLPRQPAVI
   68-  113 (64.08/35.87)	ESEPPT.KRLKLDvTSG.....AYAATGSPAPVSNGEARTTPGTATAKPQSL
  117-  158 (53.94/28.83)	GRPAWSfQALLSE.TTGAVEVKDDDASAQGKTSSSPPPLPLLP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.92|      38|     685|     696|     738|       3
---------------------------------------------------------------------------
  696-  738 (56.97/49.89)	SHRLPEHVRnlrnMLIDRAGFSLEEENSLVAKLQMSiAGRLPH
 1382- 1419 (66.95/42.94)	SHGLPEQTR....LLISIFCISLARLPNRVLRLYPS.ADYFPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.00|      26|     143|     342|     371|       5
---------------------------------------------------------------------------
  342-  370 (38.09/36.24)	LARCVGANEIRAFKRKGTsgaLALGLESK
  383-  408 (45.92/27.05)	LDGVVGICGAADWKVKMT...YAVSLTSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.06|      32|     272|    1025|    1059|      11
---------------------------------------------------------------------------
 1025- 1059 (46.93/36.14)	TMARILPPLI...GVGCVtIHAFVALVKKLLQseKVVA
 1296- 1330 (52.13/29.84)	TMIEKLAPCIpeaGVPTV.VPVLVEKMEFLLQ..KFVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.07|      10|     547|     629|     638|      12
---------------------------------------------------------------------------
  629-  638 (19.36/13.08)	LNFVAGFDSN
 1177- 1186 (18.71/12.37)	LNSLLGFDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.78|      16|      16|    1495|    1510|      13
---------------------------------------------------------------------------
 1480- 1495 (27.89/12.75)	LLGPIVDSSNPPQPTS
 1496- 1511 (29.89/14.21)	LPSPAAGGSTPTPSGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21448 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLY
2) LLSETTGAVEVKDDDASAQGKTSSSPPPLPLLPWKYTPQETPATDATKIAEIA
3) MIPHPSAGVQPWSRSMRAPNNGLGRVEAFQALNQSEPQSEKPPMPVPPSLPRQPAVIDLTTIPGDAQESEPPTKRLKLDVTSGAYAATGSPAPVSNGEARTTPGTATAKPQSLTW
4) PPQPTSLPSPAAGGSTPTPSGSLAYGQQTPQQSSTAVPS
201
126
1
1490
247
178
115
1528










Molecular Recognition Features






MoRF SequenceStartStop




1) LGRVEAFQAL
2) LKLDV
3) LLPWKYTP
4) LTTIP
23
76
156
59
32
80
163
63