Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSSLTPDQIKTLEQSRQRLVQLTHSLASLINSLNQSDPLPSWTSLQSQATIISNNLLTISDHLSDNRALLATLVAYPAPSYPSRNPANTVALEQLLRTKLDPRVEDWVARGRKAGGSLASASPPFGPGNPGNGYGGAAVGAAAGGDSGQGKGLDDLAALSELWDWAPVEANQEARRRNWGGNFTLEERERGVGNVATGLRRVLEDDDSESGSEEEESGDEEGEGEPDEMEVVGVRRKPGVGQGLEFDIAPAAPGHAAHQKVVAPVVPLDEILRFMTVGIMPSQR |
Length | 284 |
Position | Head |
Organism | Aspergillus uvarum CBS 121591 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.467 |
Instability index | 54.68 |
Isoelectric point | 4.71 |
Molecular weight | 30201.06 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21445 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 115.54| 37| 42| 26| 67| 2 --------------------------------------------------------------------------- 26- 67 (57.12/44.56) LASLInslnqSDPLPSWTSLQSQATIISNNLL......TISDHLSDNR 70- 112 (58.42/34.94) LATLV.....AYPAPSYPSRNPANTVALEQLLrtkldpRVEDWVARGR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ILRFMTV 2) LEFDIA | 271 244 | 277 249 |
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