Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSSLNQDQIKTLEQSRQRLIQLTHSLASLITSLNQSDPLPSWTSLQSQATIISNNLLTISDHLSDNRDLLSNIVAYPDASYPSRVPANNVALEQVLRTKLDPRVEDWVARGRRAGAPTTSSDAGAGALGQYQTSSGQRLLSDDAIAELWDWAPVAANEEARKRNWGGNYTLEEREMGIENVVTGLSRVLEDDDEEDESDSEEGEGEADEMEVVGARRRSGAGAGLEFDIAAANTGSGANAGAGAKVVAPVVPLDEILRFMTTGAVPGQR |
Length | 269 |
Position | Head |
Organism | Aspergillus lacticoffeatus (strain CBS 101883) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.461 |
Instability index | 49.41 |
Isoelectric point | 4.44 |
Molecular weight | 28873.35 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21439 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.89| 14| 114| 114| 127| 1 --------------------------------------------------------------------------- 114- 127 (27.12/15.14) AGAPTTS.SDAGAGA 230- 244 (21.77/10.85) AAANTGSgANAGAGA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 34.48| 10| 15| 203| 212| 3 --------------------------------------------------------------------------- 203- 212 (17.26/10.65) GEGEADEMEV 220- 229 (17.22/10.61) GAGAGLEFDI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AGAGAKVVAPVVPLDEILRFMTTGAVPG 2) GAGLEFDIAAANT 3) LLSNIVAYPDASY 4) MEVVGARRR 5) VALEQV | 240 222 69 210 90 | 267 234 81 218 95 |
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