<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21437

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMRARHVPSPGLLPSSNISPSVSPPVADQGFPIPALSRTPTHPAGFRLNPQTTPFTLSLVFSSLSGAARYFTSVLCRLIGISSIQVSLSRGSGCPGLGQPPLPSPCTPSSMSDRASSASFRAGPPSPSSPAAGTLKQNQLPAPLSDRIPQTPTSPPLMSVSAQNYATNFVSSQASPNQATSQSATLSSPPSSAPMSTQASQQPTVGTANSFPTPASSVSGHFPGATSFDDPENTDKPMGSTVPDTGAQTANMNAAAIQQAEHRRTDHDRHTEGIKMEVGVRDFAVNHGGDAMDIDSEAPASSSRSEPSLESLQKNFSSAFHVCKSSHIATGPDPSLDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKTEPGAPGSLRHMTMWPEEEWQNQKVFGKEIKVADMDSALHSLQMRAMKMEPGTVPNNEYWEDVLGHEKPSKHAGGDASKKGVAPPPNGVRIPQPNGTPAPVSDQERSRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSNSEGMGKKKRKKVGRSDGEMAF
Length547
PositionHead
OrganismAspergillus lacticoffeatus (strain CBS 101883)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.05
Grand average of hydropathy-0.630
Instability index57.76
Isoelectric point8.70
Molecular weight57844.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     246.97|      49|      50|     104|     152|       1
---------------------------------------------------------------------------
   53-  102 (44.67/12.53)	.PFTlslvFSSLSGAAryfTS.....VL.CRL..IGISSIQVSLSRGSGCPGLGQ...PPLP
  103-  151 (89.74/32.11)	SPCT....PSSMSDRA...SS.....AS.FRAGPPSPSSPAAGTLKQNQLPAPLSDRIPQTP
  152-  202 (59.40/18.93)	TS......PPLMSVSA...QNyatnfVS.SQASPNQATSQSA.TLSSPPSSAPMSTQASQQP
  203-  244 (53.16/16.22)	TVGT....ANSFPTPA...SS.....VSgHFPGATSFDDP......EN.TDKPMGSTVPDT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.50|      28|     460|       7|      37|       2
---------------------------------------------------------------------------
    7-   37 (48.27/24.89)	PSP.GL.LPSSNISPSvspPVADQGFPIPALSR
  469-  498 (47.23/18.45)	PPPnGVrIPQPNGTPA...PVSDQERSRPSRGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.93|      11|      14|     503|     513|       3
---------------------------------------------------------------------------
  503-  513 (21.72/16.45)	DDNSFVGYGEG
  519-  529 (21.21/15.88)	DDGAFYSNSEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21437 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDDGAFYSNSEGMGKKKRKKVGRSDGEMAF
2) SALHSLQMRAMKMEPGTVPNNEYWEDVLGHEKPSKHAGGDASKKGVAPPPNGVRIPQPNGTPAPVSDQERSRPSRGRKRHYDDNSFVGYGEGYA
3) SGCPGLGQPPLPSPCTPSSMSDRASSASFRAGPPSPSSPAAGTLKQNQLPAPLSDRIPQTPTSPPLMSVSAQNYATNFVSSQASPNQATSQSATLSSPPSSAPMSTQASQQPTVGTANSFPTPASSVSGHFPGATSFDDPENTDKPMGSTVPDTGAQTANMNAAAIQQAEHRRTDHDRHTEGIKMEVGVRDFAVNHGGDAMDIDSEAPASSSRSEPSLESLQKNF
517
422
91
547
515
315










Molecular Recognition Features






MoRF SequenceStartStop




1) DDGAFYSNSEGMGKKKRKKVGRS
2) FVGYGEGYAD
519
507
541
516