<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21430

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVIDGFSQIYWRIYTEEPGIIHIPGEAPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLCLWVFSPTPGFESLASVAANQGKDDSGRLLVGATTLKVSSSGSVSSSDLVKNLSAEPQNAAGAARPQRPNAPTPFVTIYASFISALMGILSLQLIQQTAAIPLGSRTLLTLDERGLDGAAGFGDESLAFAPSLTTLQVQLIAAGKLTVALQTAPQPGLLRLCNPEDDLTQTLDIAPGTDLWLSPSGSIARLVTTQPAQKTGSSPYPYSAGGMGSERSDPVNRKQWMANVLGWLTNFGLPVSGIGEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSAFSDSYGEMESVYAVIDDPLEFAEKWSVLEKPNLNEPSPKPPSVAQEAESKDQDAPTPITTDMPEGLESLSRASQYPDLQTASLVYPTPPDGATTAGLNPTTVSSDAFSEDIFSSSTFPQPTRQMSFSQPHSRNRSGTDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDDPGFDRMAEVGHANALPESPNFVETGQLEVQPTPVEHNYPNLMAEAIDGQIFEPDVEQMDVTTEAPAESPPHARDMSLPSPQEDNAGTISPPLSPVEVKKFLFPETKSESHPTPEKGHMPGYYNPIHFKQGISSWDQKYSTEGKFWFTMRDKDVSDDVIPTKSDIPTIGLLRRKTKSKNSAGGKQSDDIGSPPSVTLQKVSSDSDTSDAESIDSEEESGSESGLSPATDPSRKRKRSRSNSGSSSALSPEKTSINVEQDTTQRPEDSVFLGNFLSTFSDWSLTGYFTFPSSQTLPVLLQKDVQVQIAQILVDQVTQSSLNHKYDGSIGRPGCGNEAHSPHNVDDESFMGGIERLDLNTFVSLQDTTALSPATQARQPAQRRETSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTAAAAADSFLDRLGLVYSGCNFGNHDRGDGCNFFDRGLGSWDISWSHTRYSSTMQSLKTICEELGSALTKSPPGKENNLVVYIVNPFAHAAALVDICSAFWSLFQRYVADTDKQQARQLNELVLQIIPIDFLVSNDSLIVPPQAEYLNLALEVYSRCPPKLPHSSQVNGAPPMLLAEPLPKIINFKLSSEKTSPLQEGKCLHVACSRSQDQRWMSVAWSDNTGALQQTMSYCLRFRNSSAVRSIAEVRNEIWCATKDIMDRSQARWRVIVANTDPVDQEEVDTWTNFAEQYNKSRSTSLDLTILCVGTTAELTLEPPFLPMPMSAVNPLASATPIATPNPSISSPDQISTAPTPPSGANAPLNAPTPTETNPEIESESLLMDICDETWGVVLSHRLNSSMHQTEYRPALASGYLLRRRGSTDGDGVYTMAANIIYTRRPPGTYDSLLREILGMYRDLATLARARGTRAVQHGTLPWHLATVVKAQSLLSYVL
Length1484
PositionKinase
OrganismAspergillus saccharolyticus JOP 1030-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.373
Instability index54.03
Isoelectric point4.93
Molecular weight161748.13
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21430
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.05|      50|      55|     155|     209|       1
---------------------------------------------------------------------------
  155-  209 (69.06/51.91)	FISAlmGILSLQLiqQTAAIPLGSRTLLTLDE..RGLDGAAGfGDESLAFAPSLTTL
  213-  264 (80.99/44.62)	LIAA..GKLTVAL..QTAPQPGLLRLCNPEDDltQTLDIAPG.TDLWLSPSGSIARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     225.18|      56|      56|     420|     475|       2
---------------------------------------------------------------------------
  385-  416 (40.20/14.35)	...............DPLEFAEKWSVLEKPNLNEPSP..........KPPSVAQEAE
  420-  475 (97.43/45.34)	QDAPTPITTDMPEGLESLSRASQYPDLQTASLVYPTPPDG.ATTAGLNPTTVSSDAF
  477-  533 (87.54/39.98)	EDIFSSSTFPQPTRQMSFSQPHSRNRSGTDVTMGFGPSAGlAVGSGLYDTNDDDDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.85|      90|     247|     985|    1082|       3
---------------------------------------------------------------------------
  985- 1082 (146.04/108.28)	LAYCIHPHTAAA.............AADSFLDRLGLVYSgCNFGNHDRGDgcnffDRGLGSW.DISWSHTRYSSTMQSLKTICEELGSALTKSPPGKEnnLVVYIVNPFAHA
 1221- 1324 (143.80/85.26)	MSYCLRFRNSSAvrsiaevrneiwcATKDIMDRSQARWR.VIVANTDPVD.....QEEVDTWtNFAEQYNKSRSTSLDLTILCVGTTAELTLEPPFLP..MPMSAVNPLASA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     478.11|     128|     142|     663|     804|       4
---------------------------------------------------------------------------
  548-  646 (118.97/54.94)	................................................DADFSffDD..PGFDRMAEVGHANALPE...........SPNFVETGQLEVQPTPvehnyPNLMAEAIDGQIFEPDVEQMDVTTEAPAE..............S..PPhARDMSLPSPQ.EDNAGT...ISP
  663-  804 (199.20/129.07)	S...ESHPT..PEKGHMPGyynpiHFKQGISSWdqkySTEGKFWFtmrDKDVS..DDviPTKSDIPTIGLLRRKTK...........SKNSAGGKQSDDIGSP.....PSVTLQKVSSDSDTSDAESIDSEEESGSE..............SGLSP.ATDPSRKRKRSRSNSGSSSALSP
  808-  948 (159.93/80.07)	SinvEQDTTqrPEDSVFLG.....NFLSTFSDW....SLTGYFTF..............PSSQTLPV..LLQKDVQvqiaqilvdqvTQSSLNHKYDGSIGRP.............GCGNEAHSPHNVDDESFMGGIerldlntfvslqdtTALSP.ATQARQPAQRRETSKGTISRLGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.79|      63|     198|      79|     143|       5
---------------------------------------------------------------------------
   79-  143 (96.25/54.21)	SPTP....GFESLASVAANQgKDDSGRLLVGATTLKVSSSGsVSSSDLVKNLSAEPQNAAGAARPQRPN
  276-  342 (111.54/55.52)	SPYPysagGMGSERSDPVNR.KQWMANVLGWLTNFGLPVSG.IGEDSWVEVEVWEPFYSRLAGETWRPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.28|      11|      31|    1325|    1336|       6
---------------------------------------------------------------------------
 1325- 1336 (16.71/13.38)	TPIATpNPSISS
 1358- 1368 (21.58/11.38)	TPTET.NPEIES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21430 with Med13 domain of Kingdom Fungi
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