<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21430

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVIDGFSQIYWRIYTEEPGIIHIPGEAPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLCLWVFSPTPGFESLASVAANQGKDDSGRLLVGATTLKVSSSGSVSSSDLVKNLSAEPQNAAGAARPQRPNAPTPFVTIYASFISALMGILSLQLIQQTAAIPLGSRTLLTLDERGLDGAAGFGDESLAFAPSLTTLQVQLIAAGKLTVALQTAPQPGLLRLCNPEDDLTQTLDIAPGTDLWLSPSGSIARLVTTQPAQKTGSSPYPYSAGGMGSERSDPVNRKQWMANVLGWLTNFGLPVSGIGEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSAFSDSYGEMESVYAVIDDPLEFAEKWSVLEKPNLNEPSPKPPSVAQEAESKDQDAPTPITTDMPEGLESLSRASQYPDLQTASLVYPTPPDGATTAGLNPTTVSSDAFSEDIFSSSTFPQPTRQMSFSQPHSRNRSGTDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDDPGFDRMAEVGHANALPESPNFVETGQLEVQPTPVEHNYPNLMAEAIDGQIFEPDVEQMDVTTEAPAESPPHARDMSLPSPQEDNAGTISPPLSPVEVKKFLFPETKSESHPTPEKGHMPGYYNPIHFKQGISSWDQKYSTEGKFWFTMRDKDVSDDVIPTKSDIPTIGLLRRKTKSKNSAGGKQSDDIGSPPSVTLQKVSSDSDTSDAESIDSEEESGSESGLSPATDPSRKRKRSRSNSGSSSALSPEKTSINVEQDTTQRPEDSVFLGNFLSTFSDWSLTGYFTFPSSQTLPVLLQKDVQVQIAQILVDQVTQSSLNHKYDGSIGRPGCGNEAHSPHNVDDESFMGGIERLDLNTFVSLQDTTALSPATQARQPAQRRETSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTAAAAADSFLDRLGLVYSGCNFGNHDRGDGCNFFDRGLGSWDISWSHTRYSSTMQSLKTICEELGSALTKSPPGKENNLVVYIVNPFAHAAALVDICSAFWSLFQRYVADTDKQQARQLNELVLQIIPIDFLVSNDSLIVPPQAEYLNLALEVYSRCPPKLPHSSQVNGAPPMLLAEPLPKIINFKLSSEKTSPLQEGKCLHVACSRSQDQRWMSVAWSDNTGALQQTMSYCLRFRNSSAVRSIAEVRNEIWCATKDIMDRSQARWRVIVANTDPVDQEEVDTWTNFAEQYNKSRSTSLDLTILCVGTTAELTLEPPFLPMPMSAVNPLASATPIATPNPSISSPDQISTAPTPPSGANAPLNAPTPTETNPEIESESLLMDICDETWGVVLSHRLNSSMHQTEYRPALASGYLLRRRGSTDGDGVYTMAANIIYTRRPPGTYDSLLREILGMYRDLATLARARGTRAVQHGTLPWHLATVVKAQSLLSYVL
Length1484
PositionKinase
OrganismAspergillus saccharolyticus JOP 1030-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.373
Instability index54.03
Isoelectric point4.93
Molecular weight161748.13
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21430
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.05|      50|      55|     155|     209|       1
---------------------------------------------------------------------------
  155-  209 (69.06/51.91)	FISAlmGILSLQLiqQTAAIPLGSRTLLTLDE..RGLDGAAGfGDESLAFAPSLTTL
  213-  264 (80.99/44.62)	LIAA..GKLTVAL..QTAPQPGLLRLCNPEDDltQTLDIAPG.TDLWLSPSGSIARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     225.18|      56|      56|     420|     475|       2
---------------------------------------------------------------------------
  385-  416 (40.20/14.35)	...............DPLEFAEKWSVLEKPNLNEPSP..........KPPSVAQEAE
  420-  475 (97.43/45.34)	QDAPTPITTDMPEGLESLSRASQYPDLQTASLVYPTPPDG.ATTAGLNPTTVSSDAF
  477-  533 (87.54/39.98)	EDIFSSSTFPQPTRQMSFSQPHSRNRSGTDVTMGFGPSAGlAVGSGLYDTNDDDDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.85|      90|     247|     985|    1082|       3
---------------------------------------------------------------------------
  985- 1082 (146.04/108.28)	LAYCIHPHTAAA.............AADSFLDRLGLVYSgCNFGNHDRGDgcnffDRGLGSW.DISWSHTRYSSTMQSLKTICEELGSALTKSPPGKEnnLVVYIVNPFAHA
 1221- 1324 (143.80/85.26)	MSYCLRFRNSSAvrsiaevrneiwcATKDIMDRSQARWR.VIVANTDPVD.....QEEVDTWtNFAEQYNKSRSTSLDLTILCVGTTAELTLEPPFLP..MPMSAVNPLASA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     478.11|     128|     142|     663|     804|       4
---------------------------------------------------------------------------
  548-  646 (118.97/54.94)	................................................DADFSffDD..PGFDRMAEVGHANALPE...........SPNFVETGQLEVQPTPvehnyPNLMAEAIDGQIFEPDVEQMDVTTEAPAE..............S..PPhARDMSLPSPQ.EDNAGT...ISP
  663-  804 (199.20/129.07)	S...ESHPT..PEKGHMPGyynpiHFKQGISSWdqkySTEGKFWFtmrDKDVS..DDviPTKSDIPTIGLLRRKTK...........SKNSAGGKQSDDIGSP.....PSVTLQKVSSDSDTSDAESIDSEEESGSE..............SGLSP.ATDPSRKRKRSRSNSGSSSALSP
  808-  948 (159.93/80.07)	SinvEQDTTqrPEDSVFLG.....NFLSTFSDW....SLTGYFTF..............PSSQTLPV..LLQKDVQvqiaqilvdqvTQSSLNHKYDGSIGRP.............GCGNEAHSPHNVDDESFMGGIerldlntfvslqdtTALSP.ATQARQPAQRRETSKGTISRLGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.79|      63|     198|      79|     143|       5
---------------------------------------------------------------------------
   79-  143 (96.25/54.21)	SPTP....GFESLASVAANQgKDDSGRLLVGATTLKVSSSGsVSSSDLVKNLSAEPQNAAGAARPQRPN
  276-  342 (111.54/55.52)	SPYPysagGMGSERSDPVNR.KQWMANVLGWLTNFGLPVSG.IGEDSWVEVEVWEPFYSRLAGETWRPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.28|      11|      31|    1325|    1336|       6
---------------------------------------------------------------------------
 1325- 1336 (16.71/13.38)	TPIATpNPSISS
 1358- 1368 (21.58/11.38)	TPTET.NPEIES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21430 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSEDIFSSSTFPQPTRQMSFSQPHSRNRSGTDVTMGFG
2) KPNLNEPSPKPPSVAQEAESKDQDAPTPITTDMPEGLESLSRAS
3) LASATPIATPNPSISSPDQISTAPTPPSGANAPLNAPTPTETNPEIESES
4) MAEVGHANALPESPNFVETGQLEVQPTPVEHNYPNLMAEAIDGQIFEPDVEQMDVTTEAPAESPPHARDMSLPSPQEDNAGTISPPLSPVEVKKFLFPETKSESHPTPEKGHMPGYYNPIH
5) SDDVIPTKSDIPTIGLLRRKTKSKNSAGGKQSDDIGSPPSVTLQKVSSDSDTSDAESIDSEEESGSESGLSPATDPSRKRKRSRSNSGSSSALSPEKTSINVEQDTTQRPE
475
398
1321
562
710
512
441
1370
682
820










Molecular Recognition Features






MoRF SequenceStartStop




1) VKKFLFP
653
659