<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21426
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MHELLLFASVPAHQHHELLQQLAGLTAMQPRHRLERRLVFKAYRKPGLVTTRVGASQDLQGADFQRLNKMLNGGMYYTQVVGPVTKTDFGTAASSRMPASSDADVSMSGSGESSYCYENQPWKLEFRDIPEAGTRSAVTTRLMASASLPKGDIAIPMNAWGYSFVAEYMVEGDVFVHNDIVIFLHRVLLYPSAGSQESHGPRRQLPPYHELAPLERTGSYVLQAAITVQDGGNQELMKTASQHLFGLREQLKSAVRLEQADRLSLDTRAK |
Length | 270 |
Position | Head |
Organism | Aspergillus saccharolyticus JOP 1030-1 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.334 |
Instability index | 41.19 |
Isoelectric point | 7.91 |
Molecular weight | 29972.73 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21426
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.03| 33| 88| 29| 63| 1
---------------------------------------------------------------------------
29- 63 (50.86/37.24) QPrHRLERRLVFKAYRKPGlVTTRVGASQDLQGAD
120- 152 (60.17/35.27) QP.WKLEFRDIPEAGTRSA.VTTRLMASASLPKGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.28| 22| 181| 1| 22| 2
---------------------------------------------------------------------------
1- 22 (38.99/23.75) MHELLLFASVPAHQHHELLQQL
184- 205 (39.28/23.98) LHRVLLYPSAGSQESHGPRRQL
---------------------------------------------------------------------------
|