<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21425

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPQSSAGVQPWSRSMRAPNNGPGRVEAFQALSQSESQLEKPPMPLPQSLPRQPAVIDLTANTGDTQESEPPAKRLKLDLTPGAYATTGSPALVSSGEARTTPGIATARPQSLTWRGRPAWSFQALLSETTGAVEVKDGDATAQGKTSSSPPPLPLHPWKYSPQESPADDATKTAEAAPVKEVKTTPYRIEVPTIAPKIKGEKAADFHPWTGNHPEDVLNEHTAKQGHYDRTQVSQNESNTARPSLYTQLKHRSGLQILSSVFTAALEKRQSHNTVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVPRAIWLARCVGANEIRAFKRKGTSGTLALGLEYKWVRDWTATVQQFLEGVISTCGATDWKVKMTYAVSLTSRLFFERLLDHDQYLSWFLLSLENASLNTFPVWLLMLGIYWSNIMRYRKRGRKLAEVLLEKLQQMKKSGHQETLQPLIERLSRCIRRLVLEHTSSLILPNSWTTYRGLISSCLNLKETPDQTMFHNLVERNSRVQLSNGEQDAKVRLPQHKVITLFDSLRSAHDVPATASACLDAVEDKAILVHKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGLDIESHILSFVAGLDNSSRLNMEHLYHIFSELVRSQTFSVGRYLQWLMAKGLAHAPLPDEQVISIELRLLIQLPSHRLPEHVRNLRNMLIDRAGFSLAQERTVVAKLQMLIAGRLPHIFGLEKSGVPNNNLSFPADLTWAVKSEIGLWIRRGVAGHHRKPGRKYSNIPLLSDSGISALTTGEFYIIREILEDFGDLSMLADVLKQATTCDNCVVLASVADTVNYHFDSFCVISAVHDLFKGLVESYVRLKRFGAPNLDLIFSLIELGLRMPGEFNTVALLRQDLARIENRAAVAAPSPLSDHISVPTGQIDSLFREKLDQTLLSGGGMDESTMDTSFASLTNALQNGHKKLSPNEICRYMAYLRTFHPKRFDAMLVRWVCGLLKSQSKSTMTRILPPLIGVGCVTIHAFVTLVKKLLQSEKVIAVIPSVAELQLDLFELLIPPKQEQSRFADMVTYRFRLAQQEFLAKYPEESLDIIRDAVSVIGTEKIDTIHGSRRGDLTECATMLLQLLLTQNPERIVQSCLQKFVGQHTASTALLQKALDKLLGLNSDANDKYAPEAEKIIRMNNDFSLPFCQLKLQLLFNAEASGQDNNGIVDVMFKAALADTKSQKDHWYGLVSLMSQDAIQQIRERAEKGFFSIPMFVENAYNSNSIETARLYLTMIEKLAPCIPEAGVPTIVPVLVEKMEFLLQKFVAAQANYTGTGDARQTDPSFERSLAFWFSALLRIVVIHRASFNAAGLAPRSHGLPEQTRLLISIFCISLARLPNHVLRLYPSADYFPQPKPVESYRPCPGILLQTHALDVAACLVDIFPDEARQQCARFLREKCPPFLQFQNDARFLYLLGPILDSSNPPQPTSLPSPAAGGSTPTPSGSLTYGQHTPQQPSAAAPSVLSAGIAEGVNCIASHLRVQCRGRVIGAYPVRPWELLEDAAPIVGTNDTALSLKYFDARRVKA
Length1574
PositionKinase
OrganismAspergillus saccharolyticus JOP 1030-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.182
Instability index48.96
Isoelectric point9.10
Molecular weight175165.52
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21425
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.08|      91|     143|     926|    1021|       1
---------------------------------------------------------------------------
  926- 1021 (146.59/110.46)	VPTGQIDSLF......REKL.DQTLLSggGMDESTMD..TSFASLTNALQ....NGHKKLSPNEiCRYM..AYLRTFHPKRF.DAMLVRWVCGllKSQSKSTMTRILPPLIG
 1062- 1168 (124.49/78.91)	IPPKQEQSRFadmvtyRFRLaQQEFLA..KYPEESLDiiRDAVSVIGTEKidtiHGSRRGDLTE.CATMllQLLLTQNPERIvQSCLQKFVGQ..HTASTALLQKALDKLLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.44|      26|      48|     464|     489|       2
---------------------------------------------------------------------------
  464-  489 (43.16/29.48)	LLEKLQQMKKSGHQETLQPLIERLSR
  514-  539 (45.28/31.32)	LISSCLNLKETPDQTMFHNLVERNSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.68|      17|      48|     156|     172|       3
---------------------------------------------------------------------------
  156-  172 (33.09/19.67)	LHPWKYSPQESPADDAT
  207-  223 (34.59/20.93)	FHPWTGNHPEDVLNEHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.53|      31|      48|      72|     103|       4
---------------------------------------------------------------------------
   72-  103 (48.62/32.23)	PAKRLK..LDLTPGAYATTGSPAlVSSGEARTTP
  119-  151 (48.91/28.15)	PAWSFQalLSETTGAVEVKDGDA.TAQGKTSSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.68|      24|     140|     727|     761|       6
---------------------------------------------------------------------------
  727-  758 (37.75/49.49)	KLQMLiagrlphiFGLEKSGVPNN...NLSFPADL
 1199- 1225 (37.93/19.67)	KLQLL........FNAEASGQDNNgivDVMFKAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.95|      16|     139|     551|     566|       9
---------------------------------------------------------------------------
  551-  566 (27.25/15.77)	VRLPQHKVITLFDSLR
  692-  707 (27.71/16.17)	IQLPSHRLPEHVRNLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.93|      16|     171|     851|     866|      13
---------------------------------------------------------------------------
  851-  866 (28.62/16.77)	CV.ISAVHDLFKGLVES
 1024- 1040 (22.30/11.55)	CVtIHAFVTLVKKLLQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.56|      15|     671|     670|     691|      15
---------------------------------------------------------------------------
  670-  691 (17.38/21.53)	AKGLA...HApLPDEQvisielRLL
 1358- 1375 (23.18/ 9.43)	AAGLAprsHG.LPEQT......RLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21425 with Med12 domain of Kingdom Fungi
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