<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21422

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGIFLHRCLLHRIDAAEFRSLSRLLLQRYPINEALLLDVLLETRLATGIKWDPLLPLYIDCLCKMGLVQTSTVLNALLKYSSIHDISRSPSAEPSLRRRRSKCYTLMTDIRVVQDAMLSISTGAVPESFSEAISVFTAIIDWIQAVVAWNSNHTDHSDQTPGLINSPDTVSLFESLGILLAALSETPKGLEVLSADSQEALKIKLGQALSAYLPICVEVSLPLRTRLDSLQKGFNLYGELPTKPLDVSMMESVNVNALQFEASVMDGPIINSRAGLFVYLNAILVGRPLVDDSMLLNYLSNRYGGHYEVLIEETITAAFDVLSNASYRSESNRAMFLFRSFLVNKLPAFFAAMLAASMVTLPMELCISHALGRLDPNTFPSFSQIFTMQSNTALSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDDLVNQINANPERAEHLIGEIESMEGNAGAIVGAITEVMHNLCNQKETMTLKNICNSLSRRPQAMDVILLFRTTKQVLQPLCLLLDSWHWDEDQGESQPVYDEFGSILLLVLAFAFRYDLRAQDLGLGGSNSFVLRILEGGSCSQKLDALSDKQNKNLGGWITALFIAEGISEETMSACSPQEFYFLVATLFSQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLVLALTWLGNHIWETESDPSIPLKALHALVNPASISGESKEIHRTVLNMTARGLEEQLKDVRARHPSRTDIKPILDALEPCLIFQRSGSCHRSELDSWTNHSPGGLLGSIRSSFQSLVLWSTSPDVSVAPHSYTHRQLVTGILLLGSIRVLGALVEELKLQTEAGSGAIALDIAATLICAPMAECFAIDQNNHSHQPLDPSKETFPRCPILTLRSALILLHENIPKVSEKDPLRAEVIVRLYRRVNALMTPPSQVPNLDMNNIIQHMQLGVGGPGQMNLEAPGESGHGVSDDDAANLNRMLDNAAAAAAVGMDGGQSMGTMGLESSSGLDTSIDDVLHAADMAVGNPEFLDLDMEGLF
Length1024
PositionTail
OrganismAspergillus saccharolyticus JOP 1030-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy0.057
Instability index49.18
Isoelectric point4.98
Molecular weight112201.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21422
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.07|      24|      70|     926|     949|       1
---------------------------------------------------------------------------
  926-  949 (43.66/27.37)	MNNIIQHMQLGV.GGP..GQMNLEAPG
  967-  991 (21.64/ 9.72)	LDNAAAAAAVGMdGGQsmGTMGLES..
  999- 1022 (38.77/23.45)	IDDVLHAADMAV.GNP..EFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.36|      85|     233|     453|     551|       4
---------------------------------------------------------------------------
  453-  551 (136.94/103.32)	PERAEHLIGEIESMEGNAGAIVGAITEV.MHNLCNQ.KETMtlknicnslSRRP.........QAMDVILLFRTTKQvlqplC..LLLDSWHWDEDQGESQPVYDEFGSILL
  688-  785 (125.43/71.56)	PLKALHALVNPASISGESKEIHRTVLNMtARGLEEQlKDVR.........ARHPsrtdikpilDALEPCLIFQRSGS.....ChrSELDSWTNHSPGGLLGSIRSSFQSLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.95|      40|     483|     360|     400|       5
---------------------------------------------------------------------------
  360-  400 (68.57/46.44)	LAASMVTLPMELCI.....SHALGRLDPN..TFPSfSQIFTMQSNTAL
  839-  885 (65.38/39.35)	IAATLICAPMAECFaidqnNHSHQPLDPSkeTFPR.CPILTLRSALIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.48|      20|     628|      39|      59|       7
---------------------------------------------------------------------------
   39-   59 (32.14/20.88)	EALLLD..VLLETRLATGIkW....DP
  660-  685 (31.34/15.97)	EPFLLPslVLALTWLGNHI.WetesDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21422 with Med5 domain of Kingdom Fungi
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