<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21420
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSDRTSSASFRVGPPSPSSPAAESLKETQQTSTISSDQIPQTPTSPPLMSVSAHNYASHFAPSQTSPSQATSQNTSLSSPPSSAPMSTQPSQQPVVGGSANSFPTPASSVSGHIPAKSMGSRPSEPGATPVGAEPAIMQRAEHRRTDHDRQPAGDAESALRDSTASGDAMDIDKEEPNSLNEGGMSLESLQNNFSSAFHLCKSSYAATGPDPSLDLITLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKHEPGAPGGLLQMTMWPEEEWQNQKVFGKEIKVADMDSALHALQMKAMKMEPGAVPNSEQWEDVLGHEKPSKHAGGGGDAGKKVVAPPNGPRMQANGTPGPGVSDAERNRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSTSDGMGKKKRKKDHVSKISTPLPDRSGTYGVGMFGIGAR |
Length | 444 |
Position | Head |
Organism | Aspergillus saccharolyticus JOP 1030-1 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.791 |
Instability index | 54.60 |
Isoelectric point | 6.65 |
Molecular weight | 46834.30 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21420
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 140.84| 21| 21| 61| 81| 1
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35- 53 (23.03/ 6.45) SSDQI.PQ...TPTSPPL.MSVSA
61- 81 (35.27/13.62) APSQTSPS...QATSQNTSLSSPP
84- 104 (31.22/11.25) APMSTQPS...QQPVVGGSANSFP
107- 126 (28.15/ 9.45) ASSVSGHI...PAKSMG.SRPSEP
129- 152 (23.17/ 6.53) TPVGAEPAimqRAEHRRTDHDRQP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.45| 13| 68| 258| 272| 2
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258- 272 (22.94/17.54) GRNKPVKHEPGapGG
329- 341 (27.52/14.06) GHEKPSKHAGG..GG
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