<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21416

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWSSGQQHAPPPASPLQHQQQHSQPHAKHHARNTSASSNLSGIHRRPAIITSAQHASSPTTTSSFARSFANITATNTAGARTSTAAPSAYPVTPRPVQQLASLSPQTPVSIARLPFPSNTKVVWKRLSPLSPAQATAQSNASQDSSAPTTSAPPASQQSQQHQYTAALLDVLQLARKPALQQDRRRRLLDTPLLLAHSPKSPSDPSAPWLNATTHLSPAASCLWIFKLETQTAETHANTDDHATAPAFTNGADTTMADAQTPPTSSVDAHVAALQDDLGRFIERIALPDTLAKALLHLAPLCHIEAGSYLLASAGMPTEVQTTKGKLPILTSAQRRIHRLLTIALRSEVVSRICCTSQSRADEDGQATDAATHQGAPARRRLRLRDAVLFEPLRSNLHAAHDLSDPFSASPTSADQHSLLSRYSCSVGADAIYVSVSWRNLAALPLTTASTESLAGLVLLLAPIGLLATPISVIRPESIATDHLIRLQSAFAPMMHSDATTDSFDDWVLCTRQLQQTIHPHTHSHAQQHPRGHQSQQQHLLWPMSLCLTTSTGASLSSLHLPSSSVAAARASFAQQASTPLKELASFTLRILEDANSGTRTPFAPGEADEMIGSPTQADTNPLDAVIDYPVFGMPSVESRPTLPSEASPEKQSLQHRDRVETSGQMLSWMHAADAIPTPISRNDGSKVLTAQQSALAQSEVPSDQSNTLESFQPPPSSSHEQSSAQDALDITAASGLPNAQEHRLADPMTLTGGSQGTPQQPNAQGSKRSRIGDSDVFSNLDLLTEDDFNFFDEDAFGLSHGMSDARANDAGNPLISAMPPASRPVDFALAAHDKFSNHEDVAMADVDQSSLDALFSAIPDMQDVLMTSEPASVSGIQTHAGLLSVDMGIASGLGNAVTSSTDPYGQTSGQQNHRTVVNSNGGIASFGDDAIGGKPRDVDTGMVPHSVTAAHNARTSHVGRSGGVLPANSHMHTIAGLSAYTPREASSSASFGDPASLPGFTPSSLTESSPAFGHAANKTPRTPYSPVEEYRDTVSIVESHSVKPLRPGFSAMVYESGAEPGADASTMGDKAKLVHLQDHLTLSRDDLADGSDADRMRKRPPIVPLPFLPVGRTEPRRPLQRLSSGARINVSRKYDLLGKFGIGGAKSSDTAVLKSAHAEAKRSSVSQKQQPQQQQQNPQQKAGKGAPNPAPDADVRLSPTSAGLNSRGQSMLRTRMGRSAMTPVSTAPRSRNHRFAETASVATPRSSDDLTTVALREPVSGSDSDSDTSGDESDSEGASEAGRSLEHLSSDAQLALMQGTVDVLHADLTNEPRIGNVSSIASSTMSAPELPPSAHEANARPDNAMPLVKPWMLSRTARWLLDNPAFRNLYFSHPATTRHVISVPASERIEVLGALTEALQISDPPPWGSAPLLADLLQMPSDVVSSNSLSQPRSISNETTATETGHAAHGTDARHVGSTTKERTTSGHPSDPVVGIELMEPPRITVGCQGSVLETLPSSLALWDKTRLQAAGGPKHIVAKVLLTHASPAWNDEILAWLDRMQSVFEAYGLGTHVRGSQAILAVADELESGLSSYLDRLMGDNEAWLDTIRSISGRVRAPLLQGKHVVLYPMQNPASQACRQGGYAGLLQFEIDMRAVLRDQIGALAEHLFVRPITPSMVTESGHLGFGRQTQSLRRLAFSVYDQLPRLVRRHPAKVLHGREPGAVSALVQFPVFTLVTSMAPDDGPSTRFSLSWPRSSAHTPWSTTSIPSTVSVSSGTGAAPSQLLSASRAPRLYVAYSCGRSRSGDDGTSDVQDVVTVSAIDDQASSYATDAWMAQDTLLERLEAVWRFALCEAGRAQTAWRVVLCKAGTITEAEVEAWQSILHRSAAVFGADGDDQDVLMSSCVLVSVRPDEAGSLVHEHRDHIRPSQDWVKQAGAPTAVGDRSTSMLLDVADYSQTVRFGKPLPQAWTLRWESDDVLGLDDRKEIALPSYATADDNNNRDNNEGECAMPLVSSVLVHTPRKHALSDDSGRLVAPLDSAGRSEGCHTTAVDMLILWDPLAKHSAAYASASASASASASSATTDGPHNLSSQKVMDVLLGDMHRLRLVSEERHQLPSPHVHLPWPVAVVGMLQSCLSAVRIDYS
Length2126
PositionKinase
OrganismTesticularia cyperi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Anthracoideaceae> Testicularia.
Aromaticity0.04
Grand average of hydropathy-0.342
Instability index56.25
Isoelectric point6.01
Molecular weight226742.21
Publications
PubMed=29771364

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21416
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.51|      15|      15|    1842|    1856|       1
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 1842- 1856 (26.25/19.29)	AWRVVLCKAGTITEA
 1860- 1874 (26.26/19.30)	AWQSILHRSAAVFGA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.33|      15|      15|    1216|    1230|       2
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 1182- 1193 (21.42/ 7.85)	KAGKGAPNP...APD
 1216- 1230 (27.86/12.41)	RMGRSAMTPVSTAPR
 1232- 1246 (25.04/10.42)	RNHRFAETASVATPR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.98|      14|      15|     885|     899|       3
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  885-  898 (24.42/13.72)	SVDMGIASGLGNAV
  919-  932 (22.56/ 7.37)	NSNGGIASFGDDAI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.35|      14|      15|     844|     857|       4
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  844-  857 (23.81/14.36)	MADVDQSSLDALFS
  862-  875 (24.54/15.07)	MQDVLMTSEPASVS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.44|      11|      15|     192|     202|       5
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  192-  202 (20.85/10.12)	PLLLAHSPKSP
  208-  218 (22.59/11.66)	PWLNATTHLSP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     209.14|      45|      46|     957|    1001|       6
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   41-   69 (29.62/ 8.66)	......SGIhrRPA...IITSA.QHA.S..SPTTTSSFArS........................F
   70-  116 (51.12/20.50)	ANITATN.....TAGARTSTAAP.SA.YpvTPRPVQQLA.SLSpqTPVSiarL..........P.F
  957- 1001 (82.36/37.71)	SHVGRSGGV..LPANSHMHTIAGLSA.Y..TPREASSSA.SFG..DPAS...L..........PGF
 1004- 1050 (46.04/17.70)	SSLTESS.....PAFGH.......AAnK..TPRTPYSPVeEYR..DTVS...IveshsvkplrPGF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.38|      15|      17|    1343|    1359|       7
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 1343- 1359 (23.31/20.16)	DNamPLVKPWMLSR..TAR
 1363- 1379 (22.07/11.08)	DN..PAFRNLYFSHpaTTR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.89|      14|      16|    1444|    1458|       8
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 1444- 1458 (20.82/14.64)	ETGHAAHGTDARhVG
 1463- 1476 (26.07/13.28)	ERTTSGHPSDPV.VG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.15|      13|      26|     229|     242|       9
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  229-  242 (18.38/15.28)	ETQTAEThANTDDH
  258-  270 (23.77/13.81)	DAQTPPT.SSVDAH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     171.04|      45|     788|    1256|    1300|      10
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 1256- 1300 (74.26/38.40)	L.REPVSGSDSDSDTSGDESDSEGASEAGRSLEH.LSSDAQLALMQG
 1309- 1335 (28.60/ 9.29)	LtNEPRIGNVS.SIASSTMSAPELPPSA...................
 2038- 2082 (68.19/34.53)	L.WDPLA.KHSAAYASASASASASASSATTDGPHnLSSQKVMDVLLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     350.24|      93|    1019|     640|     797|      11
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  497-  632 (107.57/95.98)	SDATTDSFDdwVLCTRQ....lqqtiHPH.THSHAQQ.....HPRGHQSQQQHLLW.PMSLclttsTGASlsslhlpsssvaaarasfaqqastplkelasftlriledanSGT.RTPFAPGEADEMIGSP...TQADTNPLD..AVIDYPVF
  699-  797 (147.11/65.17)	SEVPSDQSN..TLESFQPPPS.....SSH.EQSSAQDALDITAASGLPNAQEHRLAdPMTL.....TGGS.........................................QGTPQQPNAQGSKRSRIGDSdvfSNLDLLTEDdfNFFDEDAF
 1720- 1788 (95.55/26.83)	SMAPDDGPS..TRFSLSWPRS.....SAHtPWSTTSIPSTVSVSSGTGAA.......PSQL.....LSAS.........................................R.APRLYVAYSCGRSRSGD.......................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.37|      51|     204|     435|     492|      13
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  435-  492 (69.96/61.67)	SVSWRnlAALPlTTASTE..SL........AGLVL.LLAPIGLLATPISviRPEsiATDHLIRLQSAFA
  636-  697 (72.40/41.99)	SVESR..PTLP.SEASPEkqSLqhrdrvetSGQMLsWMHAADAIPTPIS..RND..GSKVLTAQQSALA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     310.44|      80|     492|    1054|    1143|      15
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 1054- 1140 (121.49/96.96)	VYESgaePGADASTMGDKAKLV...HLQ.DHLTLSRDDLADGSDA..DRMRKRPPIVPLPFLPVGRTEPRRPLQRLSsgaRINVSrKYDLLGK
 1545- 1613 (79.24/44.18)	VFEA...YGLGTHVRGSQAILAvadELE.SGLSSYLDRLMGDNEAwlDTIRSISGRVRAPLLQ.GKHVVLYPMQ...................
 1615- 1688 (109.71/70.02)	.......PASQACRQGGYAGLL...QFEiDMRAVLRDQI..GALA..EHLFVR.PITPSMVTESGHLGFGRQTQSLR...RLAFS.VYDQLPR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.17|      23|     204|     351|     387|      17
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  315-  343 (33.58/32.04)	GMPTEVQTTKGklpiltSAQRRIHRLLTI
  365-  387 (39.59/14.08)	GQATDAATHQG......APARRRLRLRDA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.18|      15|      17|     129|     143|      20
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  129-  143 (25.91/13.88)	PLSPA.QATAQSNASQ
  148-  163 (23.27/11.49)	PTTSApPASQQSQQHQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21416 with Med13 domain of Kingdom Fungi
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