<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21408

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDAAGPSNSSGQQQAASTSRAQEVMLSIEPVHIYTQDLSDTAGSSTAPKLERERVLQDVTAEGKNVFVDPLPSAAQLSRDVKKLWAERGDFSKFSSQKLVDRLEKRRRRRRANLQDSSEEAGASSKGRIKAQGDDASSGTATKGGTITETEFVKLRDEVLGKLDLAHFNSIHAHQLLGMLIKAHKQQSAQSSLTAPGAGRASSPAPSVGAASARSGSVPRPAGASASNAPLSIFANLNPAGQQREGEFVLDPLAIALSKTSLNSAVSARRTVNPEDAEDEAGGGGDFDDDEENDPSNPEYGLNQARKELHSSNEYKAERLRDFKVSLATKRESIANAAQLLRSGADELRTCQASERERWRGLIALRNRGWGLTPGRPLLDVERFGAQAQNQDDEDDGEIEIVSEGNNGVSQKQKRKKSAKKPSDAKGASQPSTGLQGFGTPIVTSDGKLKEEGARDAWIGFGLAEAPVELKRRSIAYWADTTSMTSNASASGSTSSGNAGTAAPSTAAGTDRLVFPDRPRRRLRIKFVLWQPAEHAQSAGHLSASGDGRAKRKLDAVWNGRSRLEWSSDRTDKATRDEKPEAGAAVLLAQVLDTELQQASREATDEMVFGDVVAQARNLPPAFGVRLTPTSVRIVLTPRLDIVAELEAQGTTQDVEEARLQYSPFANIVLTFLRASPLRKWNAFAAATKEARRGDTPAKAAALRALAIAIPKRSAGPAGNAGGVGAASSSAGGGAQQGKNAGGGKGSDSITSALYKTDSVGPLLLTLHYWSFVARLHKLLHHLETSSLPPFKGNNHDSPSSSSPTPTTKTNALSTTSINPDRPVGSPAHLSGYAKIWLDSHLVCHLSFRQPSQLTAQFFALPSTTKKRPDVAINAHPLQLDLHTFAQLIARQLGALRGL
Length900
PositionHead
OrganismTesticularia cyperi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Anthracoideaceae> Testicularia.
Aromaticity0.05
Grand average of hydropathy-0.537
Instability index49.76
Isoelectric point9.37
Molecular weight95892.63
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21408
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.78|      16|      22|     716|     731|       1
---------------------------------------------------------------------------
    5-   20 (27.08/11.09)	AGPSNSSGQQQAASTS
  716-  731 (30.65/13.56)	AGPAGNAGGVGAASSS
  736-  750 (26.05/10.37)	AQQGKNAGG.GKGSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.05|      18|      22|     189|     209|       2
---------------------------------------------------------------------------
  189-  207 (28.91/17.91)	SAQS.SLTAPgAGRASSPAP
  213-  231 (29.13/ 8.60)	SARSgSVPRP.AGASASNAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.36|      18|      22|     423|     440|       3
---------------------------------------------------------------------------
  423-  440 (33.44/22.62)	P...SDAKGASQPSTGLQ.GFG
  442-  463 (24.92/14.52)	PivtSDGKLKEEGARDAWiGFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.53|      11|      23|     675|     688|       4
---------------------------------------------------------------------------
  675-  688 (14.19/13.73)	RASPLRkwnAFAAA
  700-  710 (17.34/ 6.72)	KAAALR...ALAIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.70|      34|     410|     102|     135|       5
---------------------------------------------------------------------------
  102-  135 (58.82/28.66)	DRL...EKRRRRRRAN..LQDSSEEAGASSKGRIKAQGD
  512-  548 (46.76/21.41)	DRLvfpDRPRRRLRIKfvLWQPAEH..AQSAGHLSASGD
  563-  585 (29.11/10.81)	SRL...EWSSDRTDKA..TRDEKPEAGA...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.20|      16|      24|     318|     333|       7
---------------------------------------------------------------------------
  318-  333 (25.81/17.70)	AERLR....DFKVSLATKRE
  339-  358 (21.39/13.35)	AQLLRsgadELRTCQASERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.14|      18|     602|     158|     181|       8
---------------------------------------------------------------------------
  163-  181 (29.43/33.25)	KLDLAHFNSIHAHQLlGML
  880-  897 (31.71/16.07)	QLDLHTFAQLIARQL.GAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.49|      28|      46|     801|     830|       9
---------------------------------------------------------------------------
  801-  830 (46.25/31.14)	SSSSPTP.TTKTNAL.STTSINPDrpVGSPAH
  848-  877 (42.24/22.01)	SFRQPSQlTAQFFALpSTTKKRPD..VAINAH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21408 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGNAGGVGAASSSAGGGAQQGKNAGGGKGSD
2) MLIKAHKQQSAQSSLTAPGAGRASSPAPSVGAASARSGSVPRPAGASASNAPLSIFANLN
3) RLEKRRRRRRANLQDSSEEAGASSKGRIKAQGDDASSGTATKGGTIT
4) RPLLDVERFGAQAQNQDDEDDGEIEIVSEGNNGVSQKQKRKKSAKKPSDAKGASQPSTGLQGFGTPIVTSDG
5) SAVSARRTVNPEDAEDEAGGGGDFDDDEENDPSNPEYGLNQARKELHSSNE
6) TSSLPPFKGNNHDSPSSSSPTPTTKTNALSTTSINPDRPVG
7) TTSMTSNASASGSTSSGNAGTAAPSTAAGTDRLVF
719
180
103
377
265
786
482
749
239
149
448
315
826
516










Molecular Recognition Features






MoRF SequenceStartStop




1) ALRALAI
703
709