<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21407

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNRLSGPPLPPPPSRSSDPVIHAESGHLNGHKVPPALGVSDSHSDKHKPISPHKLMIGVPPASTPVSTQQPSSITASSHILTNGSSTPSVGIIPIQSEKDVHALQPDNPKRKQKERDHDIMSVPLAQLEQELPLEETDLVPLAALVERLANFGYESLQNLAETLPSLPSSSKRAKIFNTALDVRKQFIKLLVLSRWSADVKDLQKARNIIALLSEQQWQHEDVFAGLTDVRKILPNARMRNADLPTAIDALRTGTYRRLPASIKDMAVAQPEFSDKQALAIVSRLNNALRTRMLCHEIVPAPLSTFTVADGKVHLRVDGLFEAYLTASGDAASPAGPDGLPTSAEATGADLEDRWWLLDLKFDVAASGSCAVSTSQLFPKRPKKAYRERLRIWGDQELAPRSTADSGAAETANTQFMPIEDTDEKAVKDVRMQDIQQDADNPEDATQPSTIAAHSSTTRSSHQPDVPLVRLFAFLQERALHYQLDMLQHQAHELCRLNWGSNLQIETRESPRSLTLRYWVHAQSDLASSSAQDRARANSAGLAAGGSITIGIADLPNQKGASRIVAELMGGDDDMHASETSIRGDDGTDTTPWSRAEAMQVRRRGLTVSWDADRAIVNDADISDLRILPHQLDVEAVLTAVIRRHTTALLHRLQRQMLVGDHRVAKLLRPEDCTILVDPVLRHHDTFVGATEDIRIEYLRIDLQGEARRRLSKTGERFSGMPPLRLGVDTISGRLLLEAADSAASGAGTSASSSTDNASNLVTGFTASSLMARPALAPLADATERINGSLDVIFDVLQRLEIFARVEEWDRKASYVGLRTVRKLNFRVQELAKFGPSVSVNGPPLLFIPLGSHFAGYFLALQPSDLMGVNFALICVAQMVDAAGATSLTLQSIEWLDRSKITAATGDAAQTSPATNLQTLQLGKRKRQAPPAPLSSTTTEATTASEAPTELEKRGHLGEMSLEELIGVHSYSLALVSYFRVEQQLRMRGIPYIHVGSSTSRPAPPDGATAQALQGDIAKDSDAEETASAPGLHNRIDSLVPALCVRATDLLSLARSHLANANVAIRVSDWNDKERMSLHIVVKLRMKSRRFRALQSVLNNVAAASGQSMVTDARTWLEFDNHTATLKFWTKDLDNCIGLFQMQWERVSRMIELTREVLNFSRAWQARALRSGQKAKRPADAIELRRFTFQDVIFSYGRTVVQEESRSDRKVNAGGEQDQIQQRSLLVRVRWQDPKIEMPAFGGMPIAYNGGYVVEFGSIPAESAVSAGAFYPEVGNDKIEVQLLERFDPAAQWFVGQHVRGNPHNVMAFELRRTVNLAARTAMAAMAATLLGGRAMGVATAGSMPHQQERFVWRGFFQLLVHTLPLIREIEPLLQKSLSDADTPELEVKAATWFRLRFLDRYALDIRLASHSRLLICDASQPLFRSPVKGLTAFNMGHDNDVYRGSQLVEQGLGSPTPLLDKKKPSTYSSEWTREQSTHQFAAIPDFEELIRDVVDAVAANAGVGQVWDLRRALLVRLVSPSSSPLSTETLPSGGDKSSAEQQSVMHQLLSLLIDKVKAKISADGSHREAPISID
Length1575
PositionTail
OrganismTesticularia cyperi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Anthracoideaceae> Testicularia.
Aromaticity0.06
Grand average of hydropathy-0.284
Instability index52.28
Isoelectric point6.58
Molecular weight172881.00
Publications
PubMed=29771364

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP21407
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     498.24|     179|     396|     227|     621|       1
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   62-  278 (246.14/103.61)	ASTPVSTQQPSSITASSHiLTNGSSTPSVGII...PIQSEKDVHaLQPDNPKRKQKE..RDHdiMSVPLaQLE.QELPLEETdlvpLAALVERLANFGYESLQNLAET..............LPSLPSSSKRAKIFNT..............................ALDVRKqfiKLLVLSrWSADvkdlqkarniiallseqqwqheDVF...AGLTDVRkILPNARMRNADLPTAIDALRTGTYRRLPAS..IKDMAVAQ...PEfsDKQA
  439-  675 (252.10/391.21)	ADNPEDATQPSTIAAHSS.TTRSSHQPDVPLVrlfAFLQERALH.YQLDMLQHQAHElcRLN..WGSNL.QIEtRESPRSLT....LRYWVHAQSDLASSSAQDRARAnsaglaaggsitigIADLPNQKGASRIVAElmggdddmhasetsirgddgtdttpwsraeAMQVRR...RGLTVS.WDAD......................RAIvndADISDLR.ILPHQLDVEAVLTAVIRRHTTALLHRLQRQmlVGDHRVAKllrPE..DCTI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.40|      38|     202|     824|     865|       2
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  824-  865 (58.99/46.21)	LNFRVQELAkfgPSVSVNGPPLLFIPlGSHFAGYFLALQPSD
 1032- 1069 (63.41/37.13)	LHNRIDSLV...PALCVRATDLLSLA.RSHLANANVAIRVSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.79|      51|     396|     884|     999|       3
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    7-   60 (91.80/39.07)	PPLP......PPPSRSSDPVIHAESGHLNGHKVPPALGVsdsHSDKHKPISPHKL.....MIGVP
  930-  991 (76.99/25.82)	PPAPlsstttEATTASEAPTELEKRGHLGEMSLEELIGV...HSYSLALVSYFRVeqqlrMRGIP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.25|      55|     389|     305|     375|       4
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  305-  364 (90.11/52.72)	TFTVA..DGKV.HLRVD..GlfEA..YLTASGDAASPAgpdGLPTSAEATGADLEDRWWLLDLKFDV
  686-  742 (62.81/24.44)	TFVGAteDIRIeYLRIDlqG..EArrRLSKTGERFS.....GMP..PLRLGVDTISGRLLLEAA.DS
  765-  796 (40.33/28.56)	...........................FTASSLMARPA....LAPLADAT....ERINGSLDVIFDV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.00|      33|     612|     372|     412|       5
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  372-  412 (42.71/38.31)	VSTSQLFPKRPKKAYRERLRiwGDqeLAprstADSGAAETA
  995- 1027 (58.29/28.45)	VGSSTSRPAPPDGATAQALQ..GD..IA....KDSDAEETA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     314.85|      99|     199|    1248|    1347|       6
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 1248- 1347 (165.88/95.38)	YNGGYVVE..FGS.IPAESAVSAGAFYPEVGNDKIEVQL..LERFDPAAQWFVgQHVRGNPHNVMAFELRRT..VNLAARTAMAAMAATLLGGRAMGVATAGSMPHQ
 1443- 1548 (148.97/81.40)	YRGSQLVEqgLGSpTPLLDKKKPSTYSSEWTREQSTHQFaaIPDFEELIRDVV.DAVAANAGVGQVWDLRRAllVRLVSPSSSPLSTETLPSGGDKSSAEQQSVMHQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.22|      25|     203|     890|     918|       7
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  890-  918 (32.16/33.25)	LQSIewLDrsKITAATGDAAQTSPATNLQ
 1094- 1118 (43.06/27.04)	LQSV..LN..NVAAASGQSMVTDARTWLE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.40|      16|     924|     201|     220|      10
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  201-  220 (20.68/29.52)	KDLQkarNIIALLsEQQWQH
 1131- 1146 (32.72/25.22)	KDLD...NCIGLF.QMQWER
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21407 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELAPRSTADSGAAETANTQFMPIEDTDEKAVKDVRMQDIQQDADNPEDATQPSTIAAHSSTTRS
2) GIIPIQSEKDVHALQPDNPKRKQKERDHDIMSVPLAQ
3) MNRLSGPPLPPPPSRSSDPVIHAESGHLNGHKVPPALGVSDSHSDKHKPISPHKLMIGVPPASTPVSTQQPSSITASSHIL
4) SPATNLQTLQLGKRKRQAPPAPLSSTTTEATTASEAPTELEKRGH
5) YIHVGSSTSRPAPPDGATAQALQGDIAKDSDAEETASAPG
397
91
1
912
992
460
127
81
956
1031










Molecular Recognition Features






MoRF SequenceStartStop




NANANA