Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MTSIATGSGSSAIRHAGTVGNARASTSAQGSASSPTAALLTSTLSAYSTLAKSLFTFIENPSHRSITVTDALADRSWTVSSAQELLSVLPEVDRLLQSRIETARQHSVNQARIEELKARAKARDRRAKQAILELHSMDNELEDLIKLADQEISSIDRAEKSPLGHSTLLAYAQRLARYTSAPPGYKLPKVATTSIPKQDAKATTTANANANAEDGGTAGAGEEGEQEPSIALGPEYNQFAKRAAAYYDPAMPSMPQEMPFPSDAMMRQGVLNSAELLAGAQMALAPSDEAGGAPGEYADMEDDEHKPFVPAFSQFHAQQQQQRQEEEEDAFDLDLN |
Length | 336 |
Position | Middle |
Organism | Testicularia cyperi |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Anthracoideaceae> Testicularia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.511 |
Instability index | 57.28 |
Isoelectric point | 4.90 |
Molecular weight | 36007.40 |
Publications | PubMed=29771364 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP21402 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.61| 14| 16| 103| 117| 2 --------------------------------------------------------------------------- 103- 117 (19.62/14.70) ARQHSVNQArIEELK 122- 135 (23.98/13.21) ARDRRAKQA.ILELH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 131.93| 37| 56| 220| 256| 3 --------------------------------------------------------------------------- 220- 256 (66.38/36.78) AGEEGEQEPSIALGPEYNQFAKRAAAYYDPAMPSMPQ 278- 314 (65.55/36.24) AGAQMALAPSDEAGGAPGEYADMEDDEHKPFVPAFSQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DAFDLDL 2) KRAAAYYDPAM 3) PGEYADMEDDEHKPFVPAFSQFHAQ | 329 241 294 | 335 251 318 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab